Genome-Wide DNA Methylation Analysis of Chinese Patients with Systemic Lupus Erythematosus Identified Hypomethylation in Genes Related to the Type I Interferon Pathway

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Frequency and predictors of the lupus low disease activity state in a multi-national and multi-ethnic cohort

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Electrophysiological Study on Cognitive Function in Systemic Lupus Erythematosus Patients With Previous Neuropsychiatric Involvement

The correlation between resting EEG power and nonattachment scale. Jicong Fan, Junling Gao, Bonnie W. Y. Wu, Ao Tan, Hinhung Sik. Poster Session, Jun, 2015. Hawaii, Conference of Human Brain Mapping. Abnormalities of Cortical Thickness and Folding in Adolescent-Onset Conduct Disorder. Bingsheng Huang, Yali Jiang, Xiao Guo, Xiaocui Zhang, Xiongzhao Zhu, Jibiao Zhang, Junling Gao, Xiang Wang, Weijun Situ, Shuqiao Yao. Poster Session, Jun, 2015. Hawaii, Conference of Human Brain Mapping. An Examination of Wisdom in the form of Nonattachment in relation to compassion meditation: A preliminary evidence from EEG. Oral presentation. Junling Gao, Spring Symposium of Young Researchers in the Science of Learning, 27-28 February 2015. The University of Hong Kong Disrupted Small-World Organization of Structural Networks in Conduct Disorder: A Preliminary Study. Guo Bin, Jibiao Zhang, Tianfu Wang, Bingsheng Huang, Yali Jiang, Shuqiao Yao, Weixiang Liu, Junling Gao. Poster Session, Jun, 2015. Hawaii, Conference of Human Brain Mapping. Jiang, Y., Guo, X., Zhang, J., Gao, J., Wang, X., Situ, W., . . . Huang, B. (2015). Abnormalities of cortical structures in adolescent-onset conduct disorder. 1-13. "Electrophysiological study on cognitive function in systemic lupus erythematosus patients with previous neuropsychiatric involvement" in its current form for publication in Clinical EEG & Neuroscience. gaoyang, rtcheung, me, estheryylau, wanjacky, temy Gao, Y Cheung, RTF Lau, EYY Wan, HY Mok, TMY Issue Date 2015 This study aimed to evaluate P300 as an electrophysiological marker of cognitive function in NPSLE patients with systemic lupus erythematosus (SLE) who had previous neuropsychiatric involvement (NPSLE) and were diagnosed to have cognitive impairment by standard neuropsychological tests. Event-related potentials (ERP) were assessed by the auditory and visual oddball paradigms. Amplitude and latency of P300 at the frontal (Fz), central (Cz) and parietal (Pz) regions were determined and compared to controls. P300 detection was performed in NPSLE patients with pre-diagnosed cognitive impairment (n=9), matched SLE patients without previous NPSLE (non-NPSLE) (n=9), and healthy controls (n=15). Auditory oddball task did not show any P300 abnormality between groups. Visual oddball task revealed reduced amplitude of P300 over Fz (p=0.002) and Cz (p=0.009) electrodes in NPSLE patients compared to healthy controls and among those who had predominant memory deficit (p=0.01 at Fz). Abnormal P300 was also observed in non-NPSLE patients at Fz and Cz. Using visual oddball paradigm, abnormal P300 was found in NPSLE patients over frontal and parietal regions compared to normal controls but was not discriminative from possible subclinical disease in non-NPSLE patients. In conclusion, visual oddball paradigm was a more sensitive electrophysiological marker than auditory oddball paradigm for cognitive impairment in NPSLE patients

Evaluation of cognitive function by electrophysiological study in systemic lupus erythematosus patients with previous neuropsychiatric involvement

OBJECTIVE: Previous studies on cognitive dysfunction evaluated by electrophysiological test in patients with systemic lupus erythematosus (SLE) who had previous neuropsychiatric involvement (NPSLE) were inconsistent. This study aimed to evaluate P300 as an electrophysiological marker of cognitive function in NPSLE patients who were diagnosed to have cognitive impairment by standard neuropsychological tests. METHODS: Event-related potentials were assessed by the auditory and visual oddball paradigms. Amplitude and latency of P300 at the frontal (Fz), central (Cz), and parietal (Pz) regions were determined and compared to controls. RESULTS: Sixteen patients with previous NPSLE were identified to have cognitive impairment, defined as one or more tests below 2 standard deviations of demographically normative data, among 20 patients recruited for comprehensive neuropsychological tests. P300 detection was performed in NPSLE patients with cognitive impairment (n=9), matched SLE patients without previous NPSLE (non-NPSLE; n=9), and healthy controls (n=15). Auditory oddball task did not show any P300 abnormality between groups. Visual oddball task revealed reduced amplitude of P300 over Fz (P=0.002) and Cz (P=0.009) electrodes in NPSLE patients compared to healthy controls and among those who had predominant memory deficit (P=0.01 at Fz). Abnormal P300 was also observed in non-NPSLE patients at Fz and Cz. CONCLUSION: P300 elicited by auditory oddball paradigm was not a sensitive electrophysiological marker for cognitive impairment in NPSLE patients. Using visual oddball paradigm, abnormal P300 was found in NPSLE patients over Fz and Pz regions compared to normal controls but was not discriminative from possible subclinical disease in non-NPSLE patients