A 6-month-old boy presented with progressive jaundice, dark urine and generalized pruritus for one month

This article has no abstract. The first 100 words appear below: A 6-month-old boy of non-consanguineous parents admitted to the Department of Pediatric Gastroenterology with the complaints of progressive jaundice, dark urine and generalized pruritus for one month. The boy was well up to five months of age. Then he developed jaundice which was progressive in nature with intermittent pale colored stool along with dark urine. His mother also complaints for generalized pruritus which was severe in intensity (disturbing sleep and daily activities) without any diurnal variations. There was no history of sib death or family history of a similar type of illness

A 6-month-old boy presented with progressive jaundice, dark urine and generalized pruritus for one month

This article has no abstract. The first 100 words appear below: A 6-month-old boy of non-consanguineous parents admitted to the Department of Pediatric Gastroenterology with the complaints of progressive jaundice, dark urine and generalized pruritus for one month. The boy was well up to five months of age. Then he developed jaundice which was progressive in nature with intermittent pale colored stool along with dark urine. His mother also complaints for generalized pruritus which was severe in intensity (disturbing sleep and daily activities) without any diurnal variations. There was no history of sib death or family history of a similar type of illness

Offshore fishery resources of the Bay of Bengal from Sandheads to Gopalpur

The paper deals with the fishery resources, species composition and seasonal fluctuations of the Bay of Bengal from Satidheads to Gopalpur with special reference to depth and nature of bottom. The fishing grounds covered by Kalyani I to V in the areas between Sandheads and Gopalpur from the very commencement of the exploratory fishing by the Government of West Bengal have been charted and the potentiality of these grounds assessed. The results of night trawling compared with the day catches are presented

Experimental fishing at ‘swatch of no Grounds’ in the Bay of Bengal

Practically no information is available regarding the fishery resources of ' Swatch of no grounds'. On 14th February 1962, an experimental trawling with Haddock type otter trawl was attempted during one of the cruises of M. V. KALYANI-N. a deep sea fishing vessel of the Directorate of Fisheries, Government of West Bengal. In view of the increasing importance to offshore fishing for stepping up the fish production it is considered worth reporting the results of this trawling operation

Series studies of the Potts model. I: The simple cubic Ising model

The finite lattice method of series expansion is generalised to the $q$-state Potts model on the simple cubic lattice. It is found that the computational effort grows exponentially with the square of the number of series terms obtained, unlike two-dimensional lattices where the computational requirements grow exponentially with the number of terms. For the Ising ($q=2$) case we have extended low-temperature series for the partition functions, magnetisation and zero-field susceptibility to $u^{26}$ from $u^{20}$. The high-temperature series for the zero-field partition function is extended from $v^{18}$ to $v^{22}$. Subsequent analysis gives critical exponents in agreement with those from field theory.Comment: submitted to J. Phys. A: Math. Gen. Uses preprint.sty: included. 24 page

Reduced Retinal Function in the Absence of Nav1.6

Background: Mice with a function-blocking mutation in the Scn8a gene that encodes Nav1.6, a voltage-gated sodium channel (VGSC) isoform normally found in several types of retinal neurons, have previously been found to display a profoundly abnormal dark adapted flash electroretinogram. However the retinal function of these mice in light adapted conditions has not been studied. Methodology/Principal Findings: In the present report we reveal that during light adaptation these animals are shown to have electroretinograms with significant decreases in the amplitude of the a- and b-waves. The percent decrease in the a-and b-waves substantially exceeds the acute effect of VGSC block by tetrodotoxin in control littermates. Intravitreal injection of CoCl 2 or CNQX to isolate the a-wave contributions of the photoreceptors in littermates revealed that at high background luminance the cone-isolated component of the a-wave is of the same amplitude as the a-wave of mutants. Conclusions/Significance: Our results indicate that Scn8a mutant mice have reduced function in both rod and the cone retinal pathways. The extent of the reduction in the cone pathway, as quantified using the ERG b-wave, exceeds the reduction seen in control littermates after application of TTX, suggesting that a defect in cone photoreceptors contributes to the reduction. Unless the postreceptoral component of the a-wave is increased in Scn8a mutant mice, the reduction in the b-wave is larger than can be accounted for by reduced photoreceptor function alone. Our data suggests that th

Biomechanics of human fetal hearts with critical aortic stenosis

Critical aortic stenosis (AS) of the fetal heart causes a drastic change in the cardiac biomechanical environment. Consequently, a substantial proportion of such cases will lead to a single-ventricular birth outcome. However, the biomechanics of the disease is not well understood. To address this, we performed Finite Element (FE) modelling of the healthy fetal left ventricle (LV) based on patient-specific 4D ultrasound imaging, and simulated various disease features observed in clinical fetal AS to understand their biomechanical impact. These features included aortic stenosis, mitral regurgitation (MR) and LV hypertrophy, reduced contractility, and increased myocardial stiffness. AS was found to elevate LV pressures and myocardial stresses, and depending on severity, can drastically decrease stroke volume and myocardial strains. These effects are moderated by MR. AS alone did not lead to MR velocities above 3 m/s unless LV hypertrophy was included, suggesting that hypertrophy may be involved in clinical cases with high MR velocities. LV hypertrophy substantially elevated LV pressure, valve flow velocities and stroke volume, while reducing LV contractility resulted in diminished LV pressure, stroke volume and wall strains. Typical extent of hypertrophy during fetal AS in the clinic, however, led to excessive LV pressure and valve velocity in the FE model, suggesting that reduced contractility is typically associated with hypertrophy. Increased LV passive stiffness, which might represent fibroelastosis, was found to have minimal impact on LV pressures, stroke volume, and wall strain. This suggested that fibroelastosis could be a by-product of the disease progression and does not significantly impede cardiac function. Our study demonstrates that FE modelling is a valuable tool for elucidating the biomechanics of congenital heart disease and can calculate parameters which are difficult to measure, such as intraventricular pressure and myocardial stresses

Drinking Water Salinity and Raised Blood Pressure: Evidence from a Cohort Study in Coastal Bangladesh.

BACKGROUND: Millions of coastal inhabitants in Southeast Asia have been experiencing increasing sodium concentrations in their drinking-water sources, likely partially due to climate change. High (dietary) sodium intake has convincingly been proven to increase risk of hypertension; it remains unknown, however, whether consumption of sodium in drinking water could have similar effects on health. OBJECTIVES: We present the results of a cohort study in which we assessed the effects of drinking-water sodium (DWS) on blood pressure (BP) in coastal populations in Bangladesh. METHODS: DWS, BP, and information on personal, lifestyle, and environmental factors were collected from 581 participants. We used generalized linear latent and mixed methods to model the effects of DWS on BP and assessed the associations between changes in DWS and BP when participants experienced changing sodium levels in water, switched from "conventional" ponds or tube wells to alternatives [managed aquifer recharge (MAR) and rainwater harvesting] that aimed to reduce sodium levels, or experienced a combination of these changes. RESULTS: DWS concentrations were highly associated with BP after adjustments for confounding factors. Furthermore, for each 100 mg/L reduction in sodium in drinking water, systolic/diastolic BP was lower on average by 0.95/0.57 mmHg, and odds of hypertension were lower by 14%. However, MAR did not consistently lower sodium levels. CONCLUSIONS: DWS is an important source of daily sodium intake in salinity-affected areas and is a risk factor for hypertension. Considering the likely increasing trend in coastal salinity, prompt action is required. Because MAR showed variable effects, alternative technologies for providing reliable, safe, low-sodium fresh water should be developed alongside improvements in MAR and evaluated in "real-life" salinity-affected settings. https://doi.org/10.1289/EHP659

STM spectra of

We have given detailed explanation of the STM spectra of \chem{Zn} impurity in superconducting BSCCO, including accurate verification of numerical data, by assuming that the spinless impurity is a Kondo hole at its two-channel fixed point. The \chem{Ni} impurity is assumed to be at its one-channel fixed point in order to explain its STM spectra. These assumptions are justified by extensive experimental evidence that the moderately doped cuprate crystal is a Kondo lattice

Multichannel Kondo approach to the cuprate and recent laser ARPES data

The existing theoretical approaches have been unable to confront the large corpus of outstanding data on the cuprate superconductor in a persuasive and unified manner. There is a general opinion now growing that these theories miss some essential points. We propose one based on multichannel Kondo effect that is physically justifiable and confronts the data adequately. In addition to earlier data, the definitive proof of involvement of this effect has been now provided by the numerical agreement of the characteristic Kondo temperatures with the fluctuation frequencies at which Eliashberg function peaks. It is, therefore, suggested that the theory of multichannel Kondo effect be accepted as the correct theory of underdoped cuprate