Transition from quintessence to phantom phase in quintom model

Assuming the Hubble parameter is a continuous and differentiable function of comoving time, we investigate necessary conditions for quintessence to phantom phase transition in quintom model. For power-law and exponential potential examples, we study the behavior of dynamical dark energy fields and Hubble parameter near the transition time, and show that the phantom-divide-line w=-1 is crossed in these models.Comment: LaTeX, 19 pages, four figures, some minor changes in Introduction, two figures added and the references updated, accepted for publication in Phys. Rev.

Using Coded Excitation to maintain Signal to Noise for FMC+TFM on Attenuating Materials

Ultrasonic Non-Destructive Evaluation using Full Matrix Capture (FMC) and Total Focusing Method (TFM) is used for high resolution imaging as every pixel is in optimal focus. FMC excites one element in turn, so operates with lower transmitted energy compared to phased array beamforming. The energy at a reflector is further reduced by the broad directivity pattern of the single element. The large number of Tx/Rx A-scans that contribute to each pixel recover the Signal-to-Noise Ratio (SNR) in the final TFM image. Maintaining this in the presence of attenuating materials is a challenge because relevant information in each A-scan signal is buried in the thermal noise, and the TFM process assumes no quantization effects in the Analogue-to-Digital Converters (ADCs) in each receiver. In-process inspection during Additive Manufacturing (AM) requires ultrasonic array sensors that can tolerate high temperatures, scan over rough surfaces and leave no residue. Dry-coupled wheel probes are a solution, but the tire rubbers are often highly attenuating, causing a problem for FMC+TFM needed to adapt the focus through the rough surface. Common approaches to maintain the SNR are to drop the frequency or to average over multiple transmissions, but these compromise resolution and acquisition rate respectively. In this paper, the application of coded excitation to maintain the SNR in the presence of high signal attenuation is explored

Scalable magnet geometries enhance tumour targeting of magnetic nano-carriers

Targeted drug delivery systems aim to increase therapeutic effect within the target tissue or organ, while reducing off-target toxicity associated with systemic delivery. Magnetic drug targeting has been shown to be an effective strategy by manipulating therapeutics inside the body using a magnetic field and an iron oxide carrier. However, the effective targeting range of current magnets limits this method to small animal experiments or superficial parts of the human body. Here we produce clinically translatable magnet designs capable of increasing exposure of tissue to magnetic fields and field gradients, leading to increased carrier accumulation. The iron oxide nanoparticle capturing efficiency was first assessed in vitro using a simple vascular flow system. Secondly, accumulation of these particles, following magnetic targeting, was evaluated in vivo using a range of different magnet designs. We observed that our bespoke magnet produced a 4-fold increase in effective targeting depth when compared to a conventional 1 T disk magnet. Finally, we show that this magnet is readily scalable to human size proportions and has the potential to target 100 nm particles up to a depth of 7 cm at specific locations of human body

Thermodynamics of cosmological horizons in f(T)f(T) gravity

We explore thermodynamics of the apparent horizon in $f(T)$ gravity with both equilibrium and non-equilibrium descriptions. We find the same dual equilibrium/non-equilibrium formulation for $f(T)$ as for $f(R)$ gravity. In particular, we show that the second law of thermodynamics can be satisfied for the universe with the same temperature of the outside and inside the apparent horizon.Comment: 18 pages, no figure, version accepted for publication in JCA

Spatiotemporal in vivo tracking of polyclonal human regulatory T cells reveals a role for innate immune cells in Treg transplant recruitment

Regulatory T cells (Tregs) are emerging as a new cell-based therapy in solid organ transplantation. Adoptive transfer of Tregs was shown preclinically to protect from graft rejection, and the safety of Treg therapy has been demonstrated in clinical trials. Despite these successes, the in vivo distribution and persistence of adoptively transferred Tregs remained elusive which hampers clinical translation. Here, we isolated human Tregs using a GMP-compatible protocol and lentivirally transduced them with the human sodium iodide symporter to render them traceable in vivo by radionuclide imaging. Engineered human Tregs were characterized for phenotype, survival, suppressive capacity, and reporter function. To study their trafficking behaviour, they were subsequently administered to humanized mice with human skin transplants. Traceable Tregs were quantified in skin grafts by non-invasive nanoSPECT/CT for up to 40 days and results validated ex vivo. Using this approach, we demonstrated that Treg trafficking to skin grafts was regulated by the presence of recipient Gr-1⁺ innate immune cells. We demonstrated the utility of radionuclide reporter gene afforded quantitative Treg in vivo tracking thereby addressing a fundamental need in Treg therapy development and offering clinically compatible methodology for future Treg therapy imaging in humans

In-process calibration of a non-destructive testing system used for in-process inspection of multi-pass welding

In multi-pass welding, there is increasing motivation to move towards in-process defect detection to enable real-time repair; thus avoiding deposition of more layers over a defective weld pass. All defect detection techniques require a consistent and repeatable approach to calibration to ensure that measured defect sizing is accurate. Conventional approaches to calibration employ fixed test blocks with known defect sizes, however, this methodology can lead to incorrect sizing when considering complex geometries, materials with challenging microstructure, and the significant thermal gradients present in materials during the inter-pass inspection period. To circumvent these challenges, the authors present a novel approach to calibration and introduce the concept of in-process calibration applied to ultrasonic Non-Destructive Testing (NDT). The new concept is centred around the manufacturing of a second duplication sample, containing intentionally-embedded tungsten inclusions, with identical process parameters as the main sample. Both samples are then inspected using a high-temperature robotic NDT process to allow direct comparative measurements to be established between the real part and the calibration sample. It is demonstrated that in-process weld defect detection using the in-process calibration technique can more reliably identify defects in samples which would otherwise pass the acceptance test using a traditional calibration

A new method for artificial breeding of Acipenser stellatus

A new formulation of GnRH and synthetic compound of anti-dopamine domperidone was used for the first time in Iran to determine suitable physiological indexes for reproduction and to resolve the present problems of artificial reproduction in stellate sturgeon Acipenser stellatus. The study was conducted on 60 breeder Acipensers including 40 female and 20 male specimens. The fish were caught at stations in the vicinity of the SefidRud River in Guilan Province. Male spawners were treated using single injection method while females received dual injection (Bio-physiological control). Propylene glycole (PG) was administered after the muscular injection near the second dorsal suite to increase theviscosity of the solution during absorption. Depending on the stage of sexual maturity in the fish, GnRH at doses of 5, 10, 15, 20, 30 mg I kg BW was used in combination with a dose of I or 2 mg I kg of domperidone. The position of GV was used as an index to determine sexual maturity in females while in males sexual maturity was determined on the basis of testis and sperm quality. The female fish showed GV in a range of 3.64 to 1430. The results indicated that reduction of stress during catch, transportation, maintenance and handling and selection of breeders with suitable morphology will result in increased reproduction success. It was also found that male breeders given a dose of 20 and 30 ;_tg I kg BW GnRH along with I and 2 mg I kg of domperidone respectively were the most successful in spermiation. For female breeders, those received a dose of 10, 15 and 20 lig I kg BW GnRH along with 2 mg I kg of domperidone exhibited the most suitable conditions in ovulation. These females responded well to artificial breeding provided they possessed GV in the range of 3.64 to 1430 depending on the water temperature until the germinal vesicle broke down (in vivo). Alleviating stress during capture, handling, transport and confinement, selecting breeders with suitable morphology and identifying correct stage of sexual maturity are the factors that help achieve higher production by substituting GnRH with a combination of GnRH and domperidone. Therefore, this compound is recommended as a suitable substitute for pituitary extract and other gonadotrophic analogues in the artificial breeding of Acipenser stellatus

Quantum entanglement in photosynthetic light harvesting complexes

Light harvesting components of photosynthetic organisms are complex, coupled, many-body quantum systems, in which electronic coherence has recently been shown to survive for relatively long time scales despite the decohering effects of their environments. Within this context, we analyze entanglement in multi-chromophoric light harvesting complexes, and establish methods for quantification of entanglement by presenting necessary and sufficient conditions for entanglement and by deriving a measure of global entanglement. These methods are then applied to the Fenna-Matthews-Olson (FMO) protein to extract the initial state and temperature dependencies of entanglement. We show that while FMO in natural conditions largely contains bipartite entanglement between dimerized chromophores, a small amount of long-range and multipartite entanglement exists even at physiological temperatures. This constitutes the first rigorous quantification of entanglement in a biological system. Finally, we discuss the practical utilization of entanglement in densely packed molecular aggregates such as light harvesting complexes.Comment: 14 pages, 7 figures. Improved presentation, published versio

Role of quantum coherence in chromophoric energy transport

The role of quantum coherence and the environment in the dynamics of excitation energy transfer is not fully understood. In this work, we introduce the concept of dynamical contributions of various physical processes to the energy transfer efficiency. We develop two complementary approaches, based on a Green's function method and energy transfer susceptibilities, and quantify the importance of the Hamiltonian evolution, phonon-induced decoherence, and spatial relaxation pathways. We investigate the Fenna-Matthews-Olson protein complex, where we find a contribution of coherent dynamics of about 10% and of relaxation of 80%.Comment: 5 pages, 3 figures, included static disorder, correlated environmen

Superradiance Transition in Photosynthetic Light-Harvesting Complexes

We investigate the role of long-lasting quantum coherence in the efficiency of energy transport at room temperature in Fenna-Matthews-Olson photosynthetic complexes. The excitation energy transfer due to the coupling of the light harvesting complex to the reaction center ("sink") is analyzed using an effective non-Hermitian Hamiltonian. We show that, as the coupling to the reaction center is varied, maximal efficiency in energy transport is achieved in the vicinity of the superradiance transition, characterized by a segregation of the imaginary parts of the eigenvalues of the effective non-Hermitian Hamiltonian. Our results demonstrate that the presence of the sink (which provides a quasi--continuum in the energy spectrum) is the dominant effect in the energy transfer which takes place even in absence of a thermal bath. This approach allows one to study the effects of finite temperature and the effects of any coupling scheme to the reaction center. Moreover, taking into account a realistic electric dipole interaction, we show that the optimal distance from the reaction center to the Fenna-Matthews-Olson system occurs at the superradiance transition, and we show that this is consistent with available experimental data.Comment: 9 page