Numerical Study of Turbulent Pulsatile Blood Flow through Stenosed Artery Using Fluid-Solid Interaction

The turbulent pulsatile blood flow through stenosed arteries considering the elastic property of the wall is investigated numerically. During the numerical model validation both standard k-ε model and RNG K-ε model are used. Compared with the RNG K-ε model, the standard K-ε model shows better agreement with previous experimental results and is better able to show the reverse flow region. Also, compared with experimental data, the results show that, up to 70% stenosis, the flow is laminar and for 80% stenosis the flow becomes turbulent. Assuming laminar or turbulent flow and also rigid or elastic walls, the results are compared with each other. The investigation of time-averaged shear stress and the oscillatory shear index for 80% stenosis show that assuming laminar flow will cause more error than assuming a rigid wall. The results also show that, in turbulent flow compared with laminar flow, the importance of assuming a flexible artery wall is more than assuming a rigid artery wall

A computational study on robust prediction of transition point over NACA0012 aerofoil surfaces from laminar to turbulent flows

AbstractFlowtransition from laminar toturbulent is prerequisite todecide whereabouts to apply surface flowcontrol techniques. This appears missing in a number of works in which thecontrol effects were merelyinvestigated without getting insight into alteration of transition position. The aim of this study is to capture the correctposition of transition overNACA0012 aerofoil at different angles of attack. Firstly, an implicit, time marching, highresolution total variation diminishing (TVD) scheme was developed to solve the governingNavier—Stokes equations forcompressible fluid flows around aerofoil sections to obtain velocity profiles around the aerofoilsurfaces. Secondly, the linear instability solver based on the Orr—Sommerfeld equations and the eN methods were developed to calculate the onset of transition over the aerofoil surfaces. Forthe low subsonic Mach number of 0.16, the accuracy of the compressible solutions was assessed bysome available experimental results of low speed incompressible flows. In allcases, transition positionswere accurately predicted which shows applicability and superiority of the present work to beextended for higher Mach number compressible flows. Here, transition prediction methodology is described and the results of this analysiswithout active flow controlor separation are presented

Magnetically assisted intraperitoneal drug delivery for cancer chemotherapy

<p>Intraperitoneal (IP) chemotherapy has revived hopes during the past few years for the management of peritoneal disseminations of digestive and gynecological cancers. Nevertheless, a poor drug penetration is one key drawback of IP chemotherapy since peritoneal neoplasms are notoriously resistant to drug penetration. Recent preclinical studies have focused on targeting the aberrant tumor microenvironment to improve intratumoral drug transport. However, tumor stroma targeting therapies have limited therapeutic windows and show variable outcomes across different cohort of patients. Therefore, the development of new strategies for improving the efficacy of IP chemotherapy is a certain need. In this work, we propose a new magnetically assisted strategy to elevate drug penetration into peritoneal tumor nodules and improve IP chemotherapy. A computational model was developed to assess the feasibility and predictability of the proposed active drug delivery method. The key tumor pathophysiology, including a spatially heterogeneous construct of leaky vasculature, nonfunctional lymphatics, and dense extracellular matrix (ECM), was reconstructed <i>in silico</i>. The transport of intraperitoneally injected magnetic nanoparticles (MNPs) inside tumors was simulated and compared with the transport of free cytotoxic agents. Our results on magnetically assisted delivery showed an order of magnitude increase in the final intratumoral concentration of drug-coated MNPs with respect to free cytotoxic agents. The intermediate MNPs with the radius range of 200–300 nm yield optimal magnetic drug targeting (MDT) performance in 5–10 mm tumors while the MDT performance remains essentially the same over a large particle radius range of 100–500 nm for a 1 mm radius small tumor. The success of MDT in larger tumors (5–10 mm in radius) was found to be markedly dependent on the choice of magnet strength and tumor-magnet distance while these two parameters were less of a concern in small tumors. We also validated <i>in silico</i> results against experimental results related to tumor interstitial hypertension, conventional IP chemoperfusion, and magnetically actuated movement of MNPs in excised tissue.</p