Measuring the systematic risk factors in Malaysia stock market returns: A principal component analysis approach

Stock market return was used as a leading indicator that measures the strength of the economy. The performance of stock market can be measured by stock market returns. However, the uncertainty in the stock market will cause systematic risk for investors. The aim of the paper to measures the systematic risk factors in Malaysia stock market. The study makes used of principal components analysis to construct a Kuala Lumpur Composite Index (KLCI) that serves a proxy variable of Malaysia stock market return and macroeconomic variables as sources of systematic risk factors. This paper used Malaysian time series data covering a period from January 2009 to December 2019. The study gives insight for understanding the components in the principal component analysis of the correlation matrix of a group of risks may contain useful financial information by identifying highly correlated pair or larger groups of risks. The results of the study can be a benefit to investor’s applies to manage their portfolio

Machine Learning to Identify Genetic Salt-Losing Tubulopathies in Hypokalemic Patients

Introduction: Clinically distinguishing patients with the inherited salt-losing tubulopathies (SLTs), Gitelman or Bartter syndrome (GS or BS) from other causes of hypokalemia (LK) patients is difficult, and genotyping is costly. We decided to identify clinical characteristics that differentiate SLTs from LK. Methods: A total of 66 hypokalemic patients with possible SLTs were recruited to a prospective observational cohort study at the University College London Renal Tubular Clinic, London. All patients were genotyped for pathogenic variants in genes which cause SLTs; 39 patients had pathogenic variants in genes causing SLTs. We obtained similar data sets from cohorts in Taipei and Kobe, as follows: the combined data set comprised 419 patients; 291 had genetically confirmed SLT. London and Taipei data sets were combined to train machine learning (ML) algorithms, which were then tested on the Kobe data set. Results: Single biochemical variables (e.g., plasma renin) were significantly, but inconsistently, different between SLTs and LK in all cohorts. A decision table algorithm using serum bicarbonate and urinary sodium excretion (FENa) achieved a classification accuracy of 74%. This was superior to all the single biochemical variables identified previously. Conclusion: ML algorithms can differentiate true SLT in the context of a specialist clinic with some accuracy. However, based on routine biochemistry, the accuracy is insufficient to make genotyping redundant

The relationship between economic growth and foreign direct investment in Malaysia analysis based on location advantage theory

Foreign direct investment is an important indicator to boost the economic growth of Malaysia. Foreign direct investment was identified as a medium in order to acquire skills, knowledge, technologies and to internationalize business and at the same time to reduce debts. However, in the year 2009, inflow of foreign direct investments into Malaysia had decline as much as 81.13 percent. McKern (1996), Kathuria (1998, 2000 and 2001) and Noorbakhsh et al., (2001) believed that foreign direct investment does not take place automatically in a nation. Whereby, inflow of foreign direct investment should be encouraged. Hence, this study aims to identify which location advantage channels and its threshold value that can influence the inflow of foreign direct investment into Malaysia. Location advantage channels were formed using human capital development, financial development and environmental condition whilst foreign direct investment was used as an interactive term as well as an independent variable. The results revealed that, without incorporating interactive terms, all the location advantage channels were able to stimulated economic growth. However, when location advantage channels were used as an interactive term with foreign direct investment, the result revealed that all the interactive term variables become insignificant towards economic growth. Thus, the study support that a certain value of location advantage channels are important as a precondition for foreign direct investment to have a positive effect on economic growth in Malaysia

Profiling the satisfaction of tourists visiting Mabul Island as a tourist destination based on demographic factors

The study aims to examine whether the satisfaction of the tourists in visiting Mabul Island as a tourist destination can be influence by demographic variables. The study involves primary data collection where questionnaire was used as the instrument to collect information. The questionnaire was distributed both physically in the island and also through Google Form. The questionnaire was distributed to 169 respondents selected through nonprobability sampling, purposive sampling method. The questionnaire was divided into 2 sections. The first section enquires information on the demography of the respondents. Section 2 measures the satisfaction of the tourists. The satisfaction was measured using 5 dimensions. The information was analysed using descriptive and inferential statistics. The result revealed that the profiling the satisfaction of tourists in choosing Mabul Island as a tourist destination were insignificant based on the demographic variables

The electroretinogram:a useful tool for evaluating age-related macular disease?

With an ageing population, the number of age-related macular disease (ARMD) cases will inevitably rise. This gives greater impetus for the need to identify the disease earlier and assess treatments to slow disease progression. Differing electroretinogram (ERG) modalities have been reviewed in relation to the objective assessment of retinal function in ARMD and for monitoring the effectiveness of clinical interventions. Conflicting results have been found with regard to the efficacy of ERG findings in the investigation of ARMD in previous years. The newer multifocal ERG paradigm provides spatial topographical information about retinal function in ARMD. It has shown promising results in monitoring effectiveness of clinical interventions and studies are continuing in this area. Better knowledge of retinal function in ARMD may lead to enhanced treatments at each phase of the disease

The effect of nutritional supplementation on the multifocal electroretinogram in healthy eyes

BACKGROUND: Previous studies have demonstrated an increase in macular pigment optical density (MPOD) with lutein (L)-based supplementation in healthy eyes. However, not all studies have assessed whether this increase in MPOD is associated with changes to other measures of retinal function such as the multifocal ERG (mfERG). Some studies also fail to report dietary levels of L and zeaxanthin (Z). Because of the associations between increased levels of L and Z, and reduced risk of AMD, this study was designed to assess the effects of L-based supplementation on mfERG amplitudes and latencies in healthy eyes. METHODS: Multifocal ERG amplitudes, visual acuity, contrast sensitivity, MPOD and dietary levels of L and Z were assessed in this longitudinal, randomized clinical trial. Fifty-two healthy eyes from 52 participants were randomly allocated to receive a L-based supplement (treated group), or no supplement (non-treated group). RESULTS: There were 25 subjects aged 18-77 (mean age ± SD; 48 ± 17) in the treated group and 27 subjects aged 21-69 (mean age ± SD; 43 ± 16) in the non-treated group. All participants attended for three visits: visit one at baseline, visit two at 20 weeks and visit three at 40 weeks. A statistically significant increase in MPOD (F = 17.0, p ≤ 0.001) and shortening of mfERG ring 2 P1 latency (F = 3.69, p = 0.04) was seen in the treated group. CONCLUSIONS: Although the results were not clinically significant, the reported trend for improvement in MPOD and mfERG outcomes warrants further investigation

Parathyroid hormone and phosphate homeostasis in patients with Bartter and Gitelman syndrome:an international cross-sectional study

Background:Small cohort studies have reported high parathyroid hormone (PTH) levels in patients with Bartter syndrome and lower serum phosphate levels have anecdotally been reported in patients with Gitelman syndrome. In this cross-sectional study, we assessed PTH and phosphate homeostasis in a large cohort of patients with salt-losing tubulopathies. Methods:Clinical and laboratory data of 589 patients with Bartter and Gitelman syndrome were provided by members of the European Rare Kidney Diseases Reference Network (ERKNet) and the European Society for Paediatric Nephrology (ESPN). Results:A total of 285 patients with Bartter syndrome and 304 patients with Gitelman syndrome were included for analysis. Patients with Bartter syndrome type I and II had the highest median PTH level (7.5 pmol/L) and 56% had hyperparathyroidism (PTH &gt;7.0 pmol/L). Serum calcium was slightly lower in Bartter syndrome type I and II patients with hyperparathyroidism (2.42 versus 2.49 mmol/L; P = .038) compared to those with normal PTH levels and correlated inversely with PTH (rs −0.253; P = .009). Serum phosphate and urinary phosphate excretion did not correlate with PTH. Overall, 22% of patients had low serum phosphate levels (phosphate—standard deviation score &lt; −2), with the highest prevalence in patients with Bartter syndrome type III (32%). Serum phosphate correlated with tubular maximum reabsorption of phosphate/glomerular filtration rate (TmP/GFR) (rs 0.699; P &lt; .001), suggesting renal phosphate wasting. Conclusions:Hyperparathyroidism is frequent in patients with Bartter syndrome type I and II. Low serum phosphate is observed in a significant number of patients with Bartter and Gitelman syndrome and appears associated with renal phosphate wasting.</p

Visual performance and aberration associated with contact lens wear in patients with keratoconus: a pilot study

Mustafa Abdu, Norhani Mohidin, Bariah Mohd-Ali Optometry and Vision Science Program, School of Healthcare Sciences, Faculty of Health Science, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, Kuala Lumpur, Malaysia Background: Rigid gas permeable (RGP) and silicone hydrogel (SH) contact lenses with specific designs are currently being used to improve visual function in patients with keratoconus. However, there are minimal data available comparing the effects of these lenses on visual function in patients with keratoconus. The objectives of this study were to compare visual acuity and contrast sensitivity using spectacles, RGP lenses, and SH lenses, and to evaluate the effects of RGP and SH lenses on higher-order aberrations and visual quality in eyes with keratoconus. The relationship between visual outcomes, aberration, and visual quality were also examined. Methods: This was a pilot study involving 13 eyes from nine subjects with keratoconus. Subjects were fitted with RGP and SH contact lenses. Visual acuity and contrast sensitivity were measured using Snellen and Pelli-Robson charts, respectively. Ocular aberrations and visual quality were measured using an OPD-Scan II device. All measurements were conducted before and after contact lens wear. Results: Significantly better visual acuity was obtained with RGP lenses than with spectacles or SH lenses (P&lt;0.001). No significant difference in contrast sensitivity values was detected between RGP and SH lenses (P=0.06). Both SH and RGP lenses significantly reduced total ocular and higher-order aberrations (P&lt;0.001) when compared with spectacles, but RGP lenses reduced trefoil, coma, and spherical aberrations more than SH lenses. No significant difference in astigmatic aberrations was found between RGP and SH lenses (P=0.12). Negative correlations were found between visual acuity and coma aberration and contrast sensitivity with higher-order aberrations and coma, trefoil, and astigmatic aberrations. Regarding visual quality, no significant difference was found between RGP and SH lenses, but RGP significantly improved visual quality when compared with spectacles (P=0.04). Conclusion: RGP lenses provided better visual acuity and greater reduction of aberrations than spectacles or SH lenses in patients with keratoconus. However, more data are needed to confirm these findings. Keywords: visual acuity, contrast sensitivity, aberration, visual quality, keratoconu

Sustainable architectural design studio towards the development of creative learning environment

The design studio has always been the key feature of architecture education. Unfortunately, the design studio in universities focused too much on cost and the uniformity of design throughout the whole campus and this leads to office-like layout which is designed without taking note on the psychological approach of the architecture students using the spaces. This paper intends to elucidate this problem and tries to find the best design solution for a sustainable architectural design studio towards an effective studio learning outcome vital for a creative learning environment. This study has found out that there are three key factors that contributed in the development of creative studio learning environment among occupants which are—the needs to have a transformable private and personal space, multi-functional interactive space and livable natural setting. This study is important because suitable architectural studio will not only provide a creative learning environment to the users but also established referential guideline for future architects