Undeca­carbonyl-1κ3 C,2κ4 C,3κ4 C-(triethyl phosphite-1κP)-triangulo-triruthenium(0)

In the title triangulo-triruthenium compound, [Ru3(C6H15O3P)(CO)11], each Ru atom has distorted octa­hedral coord­ination geometry. The monodentate phosphine ligand is equatorially coordinated to one Ru atom, leaving one equatorial and two axial carbonyl substituents on the Ru atom. Each of the remaining two Ru atoms carries two equatorial and two axial carbonyl groups. In the crystal, mol­ecules are linked into an inversion dimer by a pair of inter­molecular C—H⋯O hydrogen bonds and the dimers are stacked along the b axis

[μ-Bis(diphenyl­arsanyl)methane-1:2κ2 As:As′]nona­carbonyl-1κ3C,2κ3C,3κ3C-(triisoprop­yl phos­phite-3κP)-triangulo-triruthenium(0)

The asymmetric unit of the title triangulo-triruthenium compound, Ru3(CO)9(μ-Ph2AsCH2AsPh2)(P[OCH(CH3)2]3) or [Ru3(C25H22As2)(C9H21O3P)(CO)9], contains two mol­ecules of the triangulo-triruthenium complex. The bis­(diphenyl­arsanyl)methane ligand bridges an Ru—Ru bond and the monodentate phosphite ligand binds to the third Ru atom. Both the arsine and phosphite ligands are equatorial with respect to the Ru3 triangle. Additionally, each Ru atom carries one equatorial and two axial terminal carbonyl ligands. The dihedral angles between the pairs of benzene rings bound to individual As atoms are 85.67 (8) and 75.91 (8) in the first independent mol­ecule and 74.64 (8) and 70.76 (9) in the second. In the crystal, mol­ecules are linked into a three-dimensional framework by inter­molecular C—H⋯O hydrogen bonds

Synthesis of new seven membered heterocyclic rings: An easy access to indeno-benzo[1,4]diazepines

An easy access has been demonstrated for seven membered diazepines and a six membered quinoxaline. The reaction proceeds rapidly with low-cost and readily available chemicals at mild temperature and provides straight forward access to diazepines and quinoxaline. All final products are new and confirmed by spectral analysis and by single crystal X-ray analysis. Two crystal structures of the diazepines have very similar compositions, exhibit similar conformations where four condensed and coplanar rings are placed in the same orientation to the rest of molecule

Facile synthesis of steroidal complex having three heterocyclic moieties

370-373A convenient method for the preparation of 1′-benzylidine-4′-(cholest-5-ene-3-yl)thiosemicarbazone 2, cholest-5-en-3-spiro­{[4′-oxo-1′,3′-thiazolidin-3′′-yl)thioureido]-1′′-phenylmethylsulf­anyl}­acetic acid 3 and 3-spiro-[3′′′-(2′′′-phenyl-4′′′-oxo-1′′′,3′′′-thiazolidin-5′′-yl)-1′′,3′′,4′′-thiadiazolo-(3′,4′-b)-thiazolin]-cholest-5-ene 4 is reported

Synthesis of substituted steroidal thiadiazole, triazole and oxidotriazole

2068-2070Ethyl-5-cholesten-3β-O-acetate 2 and its thiosemicarbazide 3 have been synthesized by the reaction of 3β-hydroxycholest-5-ene 1 with ethyl chloroacetate and 2 with thiosemicarbazide in 1,4 dioxane, respectively. The thiosemicarbazide 3 on chemoselective heterocyclization with conc. H₂SO₄, conc. NaOH and iodine in the presence of alkali separately afforded 3β-[5'-amino-1',2',4'-thiadiazole-3'-methoxy]-cholest-5-ene 4,3β-[5'-mercapto-1',2',4'-triazole-3'-methoxy]-cholest-5-ene 5 and 3β-[5'-mercapto-3',5'-oxido-1',2',4'-triazolo-3'-methoxy]-5⍺-cholestane 6, respectively. The structures of these compounds have been established on the basis of elemental, analytical and spectral data

Facile synthesis of some new steroidal pyrazoline and 1′,3′,4′-oxadiazole

760-764Title compounds, 3β-[(3′-methyl-5′-oxo-2′-pyrazolin-1′-yl)­carbonyl­methoxy]cholest-5-ene 4, 3β-[5′-phenyl-1′,3′,4′-oxadia­z­ol-2′-yl]methoxycholest-5-ene 5, 3β-[5′-(4′′-chlorophenyl)-1′,3′,4′-oxadiazol-2′-yl]methoxycholest-5-ene 6, 3β-[5′-(4′′-ethylphenyl)-1′,3′,4′-oxadiazole-2′-yl)methoxycholest-5-ene 7 have been prepared by the cyclization of cholest-5-en-3β-O-acetyl hydrazide 3 using methyl acetoacetate, benzoic acid, 4-chlorobenzoic acid and 4-ethylbenzoyl chloride in presence of phosphorous oxychloride through conventional heating. Compound 5 has been prepared by two different ways

Synthesis, characterization and anticancer studies of new steroidal oxadiazole, pyrrole and pyrazole derivatives

In the present study steroidal derivatives, 3β-[5′-mercapto-1′,3′,4′-oxadiazole-2-yl]methoxy cholest-5-ene 2, 3β-[2′,5′-dimethylpyrrole-1-yl]aminocarbonylmethoxycholest-5-ene 3 and 3β-[3′,5′-dimethyl pyrazole-1-yl]carbonylmethoxycholest-5-ene 4 have been synthesized from cholest-5-en-3β-O-acetyl hydrazide 1 using CS2/KOH, acetonyl acetone and acetyl acetone, respectively as reagents and are characterized by IR, 1H NMR,13C NMR, MS and elemental analysis. Compounds 2–4 were also evaluated for anticancer activity against human leukemia cell line (HL-60) by MTT assay and compound 4 displayed the promising behavior by showing better anticancer activity

Surface Functionalization of Bioactive Hybrid Adsorbents for Enhanced Adsorption of Organic Dyes

In this study, a valuable adsorbent was functionalized using commercial ZnO and a mango seed extract (MS-Ext) as a green approach for synthesis. Fourier-transform infrared spectroscopy, transmission electron microscopy, scanning electron microscopy, and energy-dispersive X-ray analysis spectraconfirmed the presence of bioactive phenolic compounds and Cu2+ ions on the surface of ZnO. Functionalized Cu-doped ZnO/MS-Ext exhibits high efficacy in acidic, neutral, and alkaline medium, as indicated by 98.3% and 93.7% removal of methylene blue (MB) and crystal violet (CV) dyes, respectively. Cu-doped ZnO/MS-Ext has a zeta potential significantly lower than pristine zinc oxide (p-ZnO), which results in enhanced adsorption of cationic MB and CV dyes. In binary systems, both MB and CV were significantly removed in acidic and alkaline media, with 92% and 87% being removed for CV in acidic and alkaline media, respectively. In contrast, the removal efficiency of methyl orange dye (MO) was 16.4%, 6.6% and 11.2% for p-ZnO, ZnO/Ext and Cu-doped ZnO/Ext, respectively. In general, the adsorption kinetics of MB on Cu-doped ZnO/MS-Ext follow this order: linear pseudo-second-order (PSO) > nonlinear pseudo-second-order (PSO) > nonlinear Elovich model > linear Elovich model. The Langmuir isotherm represents the adsorption process and indicates that MB, CV, and MO are chemisorbed onto the surface of the adsorbent at localized active centers of the MS-extract functional groups. In a binary system consisting of MB and CV, the maximum adsorption capacity (qm) was 72.49 mg/g and 46.61 mg/g, respectively. The adsorption mechanism is governed by electrostatic attraction and repulsion, coordination bonds, and π–π interactions between cationic and anionic dyes upon Cu-doped ZnO/Ext surfaces

Zinc Oxide/Phosphorus-Doped Carbon Nitride Composite as Potential Scaffold for Electrochemical Detection of Nitrofurantoin

Herein, we present an electrocatalyst constructed by zinc oxide hexagonal prisms/phosphorus-doped carbon nitride wrinkles (ZnO HPs/P-CN) prepared via a facile sonochemical method towards the detection of nitrofurantoin (NF). The ZnO HPs/P-CN-sensing platform showed amplified response and low-peak potential compared with other electrodes. The exceptional electrochemical performance could be credited to ideal architecture, rapid electron/charge transfer, good conductivity, and abundant active sites in the ZnO HPs/P-CN composite. Resulting from these merits, the ZnO HPs/P-CN-modified electrode delivered rapid response (2 s), a low detection limit (2 nM), good linear range (0.01–111 µM), high sensitivity (4.62 µA µM−1 cm2), better selectivity, decent stability (±97.6%), and reproducibility towards electrochemical detection of NF. We further demonstrated the feasibility of the proposed ZnO HPs/P-CN sensor for detecting NF in samples of water and human urine. All the above features make our proposed ZnO HPs/P-CN sensor a most promising probe for detecting NF in natural samples

Novel Indole-Pyrazine Alkaloid: Synthesis, Characterization, and Crystal Structure

A heterocyclic molecule of a novel class with a multiple ring system has been synthesized using a new and simple strategy and acetic acid as catalyst. The structure of the title molecule has been determined by spectral analysis and single crystal X-ray diffraction analysis. The compound crystallizes in monoclinic system, space group P21/c, with two crystallographically independent molecules in an asymmetric unit. The two molecules show close comparable geometric parameters and a similar conformation of fused-ring systems. The crystal structure is stabilized by a combination of N–H⋅⋅⋅O and C–H⋅⋅⋅O hydrogen bonds, where independent molecules display equivalent interaction patterns