4 research outputs found
Supplemental Material - Effects of Gamification on Motivations of Elementary School Students: An Action Research Field Experiment
Supplemental Material for Effects of Gamification on Motivations of Elementary School Students: An Action Research Field Experiment by Mohammed Mohammed, Amal Fatemah, and Lobna Hassan in Simulation & Gaming</p
Self-Running Liquid Metal Drops that Delaminate Metal Films at Record Velocities
This paper describes a new method
to spontaneously accelerate droplets of liquid metal (eutectic gallium
indium, EGaIn) to extremely fast velocities through a liquid medium
and along predefined metallic paths. The droplet wets a thin metal
trace (a film ∼100 nm thick, ∼ 1 mm wide) and generates
a force that simultaneously delaminates the trace from the substrate
(enhanced by spontaneous electrochemical reactions) while accelerating
the droplet along the trace. The formation of a surface oxide on EGaIn
prevents it from moving, but the use of an acidic medium or application
of a reducing bias to the trace continuously removes the oxide skin
to enable motion. The trace ultimately provides a sacrificial pathway
for the metal and provides a mm-scale mimic to the templates used
to guide molecular motors found in biology (e.g., actin filaments).
The liquid metal can accelerate along linear, curved and U-shaped
traces as well as uphill on surfaces inclined by 30 degrees. The droplets
can accelerate through a viscous medium up to 180 mm/sec which is
almost double the highest reported speed for self-running liquid metal
droplets. The actuation of microscale objects found in nature (e.g.,
cells, microorganisms) inspires new mechanisms, such as these, to
manipulate small objects. Droplets that are metallic may find additional
applications in reconfigurable circuits, optics, heat transfer elements,
and transient electronic circuits; the paper demonstrates the latter
Nanoparticle Formulation Derived from Carboxymethyl Cellulose, Polyethylene Glycol, and Cabazitaxel for Chemotherapy Delivery to the Brain
Nanoparticles provide
a unique opportunity to explore the benefits
of selective distribution and release of cancer therapeutics at sites
of disease through varying particle sizes and compositions that exploit
the enhanced permeability of tumor-associated blood vessels. Though
delivery of larger as opposed to smaller and/or actively transported
molecules to the brain is <i>prima facie</i> a challenging
endeavor, we wondered whether nanoparticles could improve the therapeutic
index of existing drugs for use in treating brain tumors via these
vascular effects. We therefore selected a family of nanoparticles
composed of cabazitaxel–carboxymethyl cellulose amphiphilic
polymers to investigate the potential for delivering a brain-penetrant
taxane to intracranial brain tumors in mice. Among a small set of
nanoparticle formulations, we found evidence for nanoparticle accumulation
in the brain, and one such formulation demonstrated activity in an
orthotopic model of glioma, suggesting that such nanoparticles could
be useful for the treatment of glioma and brain metastases of other
tumor types
Additional file 1: of Measurement of blood pressure for the diagnosis and management of hypertension in different ethnic groups: one size fits all
Diagnostic output of raw data at different BP thresholds. (DOCX 19 kb