Assessment of Tamarind Seed Polysaccharide (TSP) and Hyaluronic Acid (HA) Containing Ophthalmic Solution to Maintain Tear Osmolarity, Ocular Surface Temperature (OST) and Tear Production

Background: The enhancement of ocular drug delivery is achieved by using biopolymer carriers in liquid ophthalmic preparations. Using natural polysaccharides to formulate ocular medications is attractive because they are economical and readily available. The primary goal of the study was to assess the safety and effectiveness of Tamarind seed polysaccharide (TSP)/Hyaluronic acid (HA) containing Rohto eye drops (TSP/HA drops) in alleviating the signs and symptoms of dry eye disease (DED) under dry environmental conditions using controlled environmental chamber (CEC). Methods: 12 participants were subjected to harsh environmental conditions in a CEC with a relative humidity (RH) of 5% and an ambient temperature of 21°C. TSP/HA drops were used in the two treatment modalities, protection (drops instilled before exposure to the dry environment and relief (drops instilled after exposure to the dry environment. Before and after administering drops, patients undergo screening for ocular symptoms, tear osmolarity, ocular surface temperature (OST), and tear production using the ocular Surface Disease Index questionnaire (OSDI), OcuSense TearLab Osmometer, FLIR System ThermaCAM P620, and phenol red test (PRT) respectively. Tear production was calculated by the Tear Function Index test (TFI). Results: Before (protection) and after (relief) exposure to the dry environment, TSP/HA resulted in a mean tear osmolarity of 296.0 mOsm/L and 292.0 mOsm/L, with no significant statistical difference. The presence of TSP/HA in both protection and relief modes led to an increase in tear production. TSP/HA drops did not significantly affect OST compared to the absence of TSP/HA drops at 5% RH. There was a significant increase in mean symptom score from 14 at 40% RH to 128 at 5% RH (p=0.003). A substantial reduction in symptoms was found in both protection (before exposure) (35) (p=0.003) and relief (after exposure) (50) (p=0.005) compared to when no drop was used. Conclusion: It was apparent that using TSP/HA for protection was superior to relief for osmolarity and eye comfort. To optimise the therapeutic efficacy of TSP/HA, it is advisable to instruct patients to administer it before exposure to dry atmospheric conditions. The small sample size limits the ability to generalize the findings. Future studies should evaluate the tear supplement with a larger sample to improve statistical power.</p

Enhancing water treatment with polyvinylidene fluoride (PVDF)/cellulose composite membranes : a comprehensive review

This study delves into the critical examination of prior research on PVDF/cellulose membranes and their applicability in water treatment contexts. Raw water sources are typically laden with contaminants, organic compounds, soil particulates, and humic substances, all of which contribute to membrane fouling. The challenge escalates when membranes lack adequate hydrophilicity, resulting in heightened costs for water treatment, notably in regions with swampy or peaty water sources. Despite the potential of hydrophilic biopolymers like cellulose as a solution, their complex and crystalline structure poses handling difficulties. This review aims to deepen our understanding of the significant potential of PVDF/cellulose membranes as sustainable and effective solutions for water treatment. These membranes showcase promising attributes such as high water flux and straightforward production processes. Our goal is to promote the broader utilization of this widely available biopolymer to enhance the performance and sustainability of PVDF membrane filtration in water treatment applications

Prevalence of keratoconus among patients seeking laser vision correction in Taif area of Saudi Arabia

Purpose: To determine the prevalence of keratoconus among patients seeking laser vision correction (LVC). Methods: Retrospective study of 1374 eyes of 687 patients (335 males, 352 females) who underwent keratoconus screening as a part of routine preoperative evaluation prior to LVC at the Tadawi surgical centre, Taif, Saudi Arabia from January 2014 to June 2015. The diagnosis of keratoconus was based on evaluation of Pentacam derived parameters. Results: Manifest keratoconus was found in 59 subjects (out of 687 subjects) representing a prevalence rate of 8.59%. Of the 687 subjects, 45 subjects (6.55%) had bilateral manifest keratoconus (manifest keratoconus in both eyes or manifest keratoconus in one eyes and sub-clinical in contralateral eye) and remaining 14 patients (2.04%) had unilateral manifest keratoconus (with normal fellow eye). Sub-clinical keratoconus was diagnosed in 65 patients representing a prevalence rate of 9.46%. Of the 687 patients, 20 cases (2.91%) with subclinical keratoconus were bilateral and 45 (6.55%) were unilateral. Overall, 19.70% males (66/335) and 16.48% (58/352) females had either manifest or sub-clinical keratoconus, representing no statistically significant difference in the gender predisposition of the keratoconus disease process (Chi Square test; p = .277). Conclusion: High prevalence of keratoconus was found among patients seeking LVC. Possible factors contributing to the high prevalence were recognized to be highly selective population (patients seeking LVC for myopia/hyperopia/astigmatism), ethnicity (high prevalence of consanguinity) and geographical location (high altitude) of the study subjects. Keywords: Prevalence of keratoconus, Sub-clinical keratoconus, Saudi Arabia, Laser vision correction, Epidemiolog

Risk and Preventive Measures Among Older Adults in Nursing Homes in Saudi Arabia: An Exploratory Study on Falls

Background: Falls among older adults are a pervasive and significant concern worldwide. A practice guideline has been developed to address the prevention of falls and their resulting consequences in hospital and long-term care settings. Aim: The study aimed to assess the fall down rate and preventive tools among older adult patients in nursing homes. Methods: A cross-sectional study was conducted on randomly selected older adult patients by using a questionnaire with the Stopping Elderly Accidents, Deaths, and Injuries (STEADI) tool in nursing homes at the Ministry of Human Resource and Social Development. Results: Among 323 older adult patients, most of them (73.1%) were male, 23.8% were from Makkah, and the age ranged from 60 to 90 years and older. Results showed that 64.8% had a psychiatric disorder, 41.8% had hypertension, 38.4% had diabetes, 38.1% had movement disorders, 11.3% had heart diseases, and 1.5% had no chronic conditions. The mean STEADI tool score was 3.5 out of 12, and of the 323 older adult patients, 51.7% had a low risk to fall and 48.3% had a high risk to fall. Of the 13 interventions used to prevent falls, the most used intervention was rehabilitative physical therapy, followed by providing patient facilities and muscle strengthening exercises. Conclusions: The level of falls was markedly low, and a significant correlation was observed between the risk of falling and the participants&rsquo; region of residence

Kinetics of Electrocatalytic Oxygen Reduction Reaction Over an Activated Glassy Carbon Electrode in an Alkaline Medium

Hydrogen peroxide is a promising substitute for fossil fuels because it produces non-hazardous by-products. In this work, a glassy carbon GC was anodized in sulphuric acid at +1.8 V to prepare the working electrode. It was utilized to investigate the oxygen reduction reaction (ORR) in a basic medium containing 0.1 M NaOH as a supporting electrolyte. The objective of this investigation was to synthesize hydrogen peroxide. X-ray photoelectron spectroscopy (XPS), electrochemical impedance spectroscopy (EIS), linear polarization, cyclic voltammetry (CV), and rotating disk electrode voltammetry (RDE) were performed for characterization and investigation of the catalytic properties. The RDE analysis confirmed that oxygen reduction reactions followed two electrons’ process at an activated GC electrode. Hence, the prepared electrode generated hydrogen peroxide from molecular oxygen at a potential of around −0.35 V vs. Ag/AgCl (sat. KCl), significantly lower than the pristine GC surface. The transfer coefficient, standard reduction potential, and standard rate constant were estimated to be 0.75, −0.27 V, and 9.5 × 10−3 cm s−1, resectively

Etiology, Pathogenesis, Diagnosis, and Treatment of Fibromyalgia Syndrome

Fibromyalgia is a common syndrome (FM) that is prevalent all over the world with different prevalence rates in each country. The etiology and pathogenesis of fibromyalgia are still unknown, unclear, and with uncertain pathophysiology. Diagnosis of fibromyalgia is not that easy because the disease is described as multifactorial, and very little information is known about the causes of the disease. Treatment of fibromyalgia is not totally curative; treatment aims to improve and alleviate the symptoms as easing pain, improving sleep, develop the physical function. The main problem with fibromyalgia is not only difficulty of diagnosis or poor prognosis, but also the treatment is not adequate or satisfactory, so it is of great importance to educate the patients about their illness and giving them advice on how to limit the risk factors that aggravate the case, besides educating patients to use non-pharmacological strategies for better management.</jats:p