Evaluation of Central Auditory Processing of Azeri-Persian Bilinguals Using Dichotic

 Objectives: Sometimes there is no hearing impairment, but it is possible to have an auditory disorder. This is known as a central auditory processing disorder (CAPD). Verbal dichotic tasks are useful tools to evaluate CAPD, but there is almost no tool to assess this for Azeri people in their native language. The aim of this study is to evaluate central auditory processing of Azeri participants by Azeri dichotic digit test (ADDT).Materials & Methods: Participants were 52 normal Iranian Azeri students (mean age 23.27± 4.71 ; 26 female, 26 male).They were chosen by convenient sampling. ADDT was constructed and administered in free recall format along with a Persian dichotic digit test (PDDT). After two to four weeks, reliability was performed. Results: The mean of the right ear score of PDDT and ADDT were 98.90 and 99.09 percent, respectively. ADDT was reliable in almost all scores. There was no significant difference in performance between men and women in any score of both tests (p>0.05). The results showed a significant difference between both ears’ scores in PDDT (p<0.02) as well as in ADDT (p=0.00). The right ear advantage were seen in both tests. Conclusions: All participants performed significantly better on numbers presented in the right ear than the left ear in both tests. Central auditory processing of Azeri participants for Azeri is similar to that for Persian.

Ototoxic and Vestibulotoxic Effects of Chloroquine/Hydroxychloroquine and Remdesivir in the Treatment of COVID-19: Update Review

Introduction: Antiviral drugs have been extensively used as a potential treatment during the COVID-19 pandemic. Based on previous studies, there were concerns about some of these drugs’ ototoxic and vestibulotoxic effects. Still, these concerns were exacerbated by the widespread use of these drugs at the beginning of the COVID-19 pandemic. Therefore, this article was done to comprehensively review the effects of ototoxicity and vestibulotoxicity of chloroquine (CQ)/hydroxychloroquine (HCQ) and remdesivir with different administration models and compare with the COVID-19 treatment guidelines in the world and Iran. Materials and Methods: This study collected the related published studies in PubMed, Scopus, Google Scholar, and Web of Science with the main keywords “chloroquine”, “hydroxychloroquine”, “remdesivir”, “ototoxicity”, “vestibulotoxicity”, and “COVID-19”. Results: The dose or duration of used HCQ/CQ drugs that caused ototoxic or vestibulotoxic effects in some diseases was reported mainly more than in COVID-19 guidelines, especially in Iran. These findings align with a recent study on slight HCQ-induced ototoxicity in patients with COVID-19 at low doses and short lengths of use. No evidence of possible cochlear damage after taking remdesivir is reported. Conclusion: It seems that the concern about the ototoxic effects of some drugs used in the COVID-19 pandemic should be according to some factors that affect the pharmacological effects of drugs, such as dose, length of use, and co-administration of drugs. Therefore, lower dosage and length of use in some administration models in COVID-19 treatment, such as Iran, are associated with limited and reversible ototoxicity effects. However, further studies are needed

Effect of Age on the Score of the Persian Version of the University of Cincinnati Auditory Processing Inventory: A Pilot Study

Background and Aim: The Persian version of the University of Cincinnati Auditory Processing Inventory (P-UCAPI) is used to evaluate auditory processing disorders in Iranian people using six subscales, each focusing on different auditory skills. In this study, we aimed to compare the total score and the subscale scores of the P-UCAPI among three age groups to evaluate the impact of aging on auditory processing. Methods: Participants in three age groups of 20, including 21–39 years (group A), 42–60 years (group B), and 61–80 years (group C) completed the P-UCAPI. One-way ANOVA and Welch’s t-test was used to compare the mean scores of each subscale among the three groups. Results: The mean scores of listening and concentrating (p<0.001), understanding speech (p<0.001), attention (p=0.010), and other (p<0.001) were significantly lower in group C compared to group A. The mean scores of listening and concentrating (p=0.001), understanding speech (p<0.001), and other (p<0.001) were significantly lower in group C compared to group B. The mean total score was not significantly different between groups A and B (p=0.333). However, the difference was significant between groups A and C (p<0.001) and between groups B and C (p<0.001). Conclusion: The increase of age affects the auditory processing and generally reduces the auditory performance

Effect of Subliminal Auditory Stimulation on Components of Auditory Late Responses and Functional Magnetic Resonance Imaging Data in Adults with Normal Hearing

Background and Aim: The use of subliminal stimulation for unconscious effects on the target population is of great importance. while several studies have generated proper visual and auditory stimuli for subliminal stimulation, no study was found on the long-term effects of it. Therefore, this study aims to investigate the long-term effects of auditory subliminal presentation on the central nervous system structures using fMRI and Auditory Late Responses (ALRs). Methods: Participants were 26 students with a mean age of 24.03±2.32 years. There was four group in study. First, fMRI was done and ALRs were recorded for all of them. Then, music files containing words embedded in them was presented subliminally to participants in groups A and B for 10 days, group C received music file without any subliminal stimuli and group D was control group. It was repeated after 10 days. Results: The subliminal stimuli had significant effects on the amplitudes of P1, N1, P2, and P3 waves (F3=25.03, 25.41, 39.11, and 14.60; p<0.001). Between-group comparison showed significant changes in groups A and B compared to groups C and D (p<0.05). The difference in the recorded potential mean values showed the highest change for recording electrodes in the prefrontal, frontal, and central regions and the lowest change in parietal and occipital regions. There was no significant change for a latency component. Conclusion: Subliminal stimuli, presented appropriately and continuously, can leave longterm effects on the central nervous system structure causing extensive changes in the people’sattitude to a certain subject

Otoacoustic Emissions and Their charactristics

OAEs are sound founds in the external aditory meatus that originate in the cochlea. OAEs are generated only when the organ of corti is in near normal condition and They can be detected only when the middle ear system is operating normally. The sound generated by the cochlea are small but  potentially audible, sometimes as much as 30 dBSPL. They can emerge spontaneously in the cochlea, but more commonly OAEs follow acoustic stimulation. No electrod are needed to  observe OAEs. In fact, microphone are used to detect them

Comparison of Auditory Brainstem Response in Noise Induced Tinnitus and Non-Tinnitus Control Subjects

Background and Aim: Tinnitus is an unpleasant sound which can cause some behavioral disorders. According to evidence the origin of tinnitus is not only in peripheral but also in central auditory system. So evaluation of central auditory system function is necessary. In this study Auditory brainstem responses (ABR) were compared in noise induced tinnitus and non-tinnitus control subjects.Materials and Methods: This cross-sectional, descriptive and analytic study is conducted in 60 cases in two groups including of 30 noise induced tinnitus and 30 non-tinnitus control subjects. ABRs were recorded ipsilateraly and contralateraly and their latencies and amplitudes were analyzed.Results: Mean interpeak latencies of III-V (p= 0.022), I-V (p=0.033) in ipsilatral electrode array and mean absolute latencies of IV (p=0.015) and V (p=0.048) in contralatral electrode array were significantly increased in noise induced tinnitus group relative to control group. Conclusion: It can be concluded from that there are some decrease in neural transmission time in brainstem and there are some sign of involvement of medial nuclei in olivery complex in addition to lateral lemniscus

Comparison of Gap in Noise Test Results Between Congenital Blind and Sighted Subjects With Normal Hearing

Background and Aims: Main feature of auditory processing abilities is temporal processing including temporal resolution, temporal ordering, temporal integration and temporal masking. Many studies have shown the superiority of blinds in temporal discrimination over sighted subjects. In this study, temporal processing was compared in congenital blind subjects with sighted controls via gap in noise test (GIN).Methods: This analytic-prescriptive non-invasive cohort study was conducted on 22 congenital blinds (11 males and 11 females) with a mean age of 26.22 years and 22 sighted control subjects (11 males and 11 females) with a mean age of 24.04 years with normal hearing in faculty of Rehabilitation Tehran University of Medical Sciences. Gap in noise test results, approximate threshold and percent of corrected answers, were obtained and then, were analyzed by Mann-Whitney non-parametric statistical test.Results: There was a significant difference in the approximate threshold and the percent of corrected answers between congenital blinds and sighted control subjects (p&lt;0.05). However, there was no significant difference between males and females in this regard (p&gt;0.05).Conclusion: Auditory temporal resolution ability, the lower approximate threshold and the more corrected answers in gap in noise, in blind subjects is better than the sighted control group and it might be related to the compensative neuroplasticity after visual deprivation

Evaluating the effectiveness of dichotic training in the elderly adults: a single subject study

Background and Aim: Elderly people usually show poor performance in dichotic listening tasks. In this condition, the left ear being often the weaker one shows a performance below the normal limits. Studies have shown the effectiveness of dichotic listening training in auditory and language processing for adults and children with neurological disorders. This study aimed to deve­lop a home-version of dichotic training and investigate its effectiveness in elderly adults. Methods: Participants in this single-subject interventional study (AB design) were four elderly subjects (two males and two females) aged 65−75 years. The main inclusion criteria were dichotic listening deficit demonstrated by the dichotic digit test (DDT), no neurological or cognitive disorders, and normal hearing threshold. Dichotic listening training was performed with an informal home-version of dichotic interaural intensity difference (DIID) training program for seven weeks. DDT was performed seven consecutive weeks before (phase A) and after the intervention (phase B) at the end of each week. Results: Data were analyzed by single-subject study statistics. Findings demonstrated an imp­rovement in DDT scores for the left ear and decrease in right ear advantage scores in all the elderly adults after DIID training program. It seems that this training program could remediate poor performance in dichotic listening tasks in elderly people. Conclusion: The advantage of this method is that it can be easily done at home and is cost-effective. However, further studies are needed to approve the neuroplasticity and structural chan­ges in the brain after the DIID training program in this population