Study of anomalous top quark FCNC interactions via tWtW-channel of single top

The potential of the LHC for investigation of anomalous top quark interactions with gluon ($tug,tcg$) through the production of $tW$-channel of single top quark is studied. In the Standard Model, the single top quarks in the $tW$-channel mode are charge symmetric meaning that $\sigma(pp\to t+W^{-}) = \sigma(pp\to \bar{t}+W^{+})$. However, the presence of anomalous FCNC couplings leads to charge asymmetry. In this paper a method is proposed in which this charge asymmetry may be used to constrain anomalous FCNC couplings. The strength of resulting constraints is estimated for the LHC for the center of mass energies of 7 and 14 TeV.Comment: 13 pages, 4 figures, new references adde

Preliminary assessment of various additives on the specific reactivity of anti- rHBsAg monoclonal antibodies

Background: Antibodies have a wide application in diagnosis and treatment. In order to maintain optimal stability of various functional parts of antibodies such as antigen binding sites, several approaches have been suggested. Using additives such as polysaccharides and polyols is one of the main methods in protecting antibodies against aggregation or degradation in the formulation. The aim of this study was to evaluate the protective effect of various additives on the specific reactivity of monoclonal antibodies (mAbs) against recombinant HBsAg (rHBsAg) epitopes. Methods: To estimate the protective effect of different additives on the stability of antibody against conformational epitopes (S3 antibody) and linear epitopes (S7 and S11 antibodies) of rHBsAg, heat shock at 37°C was performed in liquid and solid phases. Environmental factors were considered to be constant. The specific reactivity of antibodies was evaluated using ELISA method. The data were analyzed using SPSS software by Mann-Whitney nonparametric test with the confidence interval of 95%. Results: Our results showed that 0.25 M sucrose, 0.04 M trehalose and 0.5% BSA had the most protective effect on maintaining the reactivity of mAbs (S3) against conformational epitopes of rHBsAg. Results obtained from S7 and S11 mAbs against linear characteristics showed minor differences. The most efficient protective additives were 0.04 M trehalose and 1 M sucrose. Conclusion: Nowadays, application of appropriate additives is important for increasing the stability of antibodies. It was concluded that sucrose, trehalose and BSA have considerable effects on the specific reactivity of anti rHBsAg mAbs during long storage. © 2015, Avicenna Journal of Medical Biotechnology. All rights reserved

The effectiveness of the 4-stage approach compared to traditional clinical teaching among midwifery student's about delivery management skills

Background & Aim: Since, employing new training methods is necessary for enhancing medical students` skills so the aim of this study was to determination of the effectiveness of the 4-stage approach compared to traditional clinical teaching among midwifery student's about delivery management skills. Methods and Material: This was an experimental study, performed in 30 midwifery students (15 students in each group) in 2013-2014 in Isfahan University of Medical Sciences. At first, their delivery management skills were evaluated with an standard checklist then the first group participated in(case) 4-stage approach and the second one participated in (control)traditional clinical teaching. Their delivery management skills were re-evaluated by standard checklist after the course. The collected data was analyzed using SPSS v14 and independent t-test and paired test. The significant level was considered less than 0.05 Results: The findings of independent t test did not show any significant difference between skills scores of two groups before intervention while a statistically significant difference was observed in after intervention between the scores of two groups (p=.001). Paired t test showed a statistically significant difference in skills score in two group after intervention Four-stage teaching technique and traditional group respectively (p=.013, p=.003). Also rate of skills increased in Four-stage teaching technique group and traditional group was 77% and 12% (p=.006). Conclusion: Four-stage teaching technique can be increased delivery management skills levels in midwifery students. So, the conduction of this educational model is recommended as an effective learning. In delivery management skills