Is adiponectin associated with acute myocardial infarction in Iranian non obese patients?

<p>Abstract</p> <p>Backgrounds</p> <p>Adiponectin is an adipose tissue-derived mediator with significant anti-atherogenic properties. A few studies were done in acute phase of myocardial infarction especially in non obese patients. We design a study to investigate the association between adiponectin concentration and acute phase of myocardial infarction in non obese patients.</p> <p>Methods</p> <p>This case-control study was done in Paymaneah Hospital (Jahrom, Iran) from Feb 2007 to May 2008. Plasma adiponectin levels were measured in 43 patients with AMI (mean age: 62.7 ± 13.3 years, male: 67.4%) at the first 24 hours of admission and 43 normal controls (mean age: 62.1 ± 12.3 years, male: 55.8%) matched for age, sex and other CAD risk factors.</p> <p>Results</p> <p>Adiponectin levels in patients with AMI (3.36 μg/mL) were significantly lower than that of the control group (5.03 μg/mL) (p < 0.0001). Lower adiponectin were independently associated with higher risk of AMI (odds ratio = 8.97; 95% CIs: 2.3–34.5; p = 0.001). Adiponectin levels negatively correlated with triglyceride (r = -0.46, p = 0.002) and total cholesterol (r = -0.32, p = 0.03) in the case group and with body mass index (BMI) in control subjects.</p> <p>Conclusion</p> <p>The present study showed that adiponectin was associated with AMI in non obese patients but it is not related to sex, age and other CAD risk factors.</p

Quality management systems selection using FAHP and mixed integer programming

In current paper, an organized and quantitative approach is proposed for selection of quality management systems. The proposed model of this paper first uses fuzzy analytic hierarchical process to rank different quality management systems. Since there are normally various constraints associated with the selection of quality management, we propose a 0-1 programming for selecting an optimal mix of quality management systems. We also use the proposed model of this paper for a real-world case study of research center in aerial industries and the results are discussed

Annexin V and anti-Annexin V antibodies: two interesting aspects in acute myocardial infarction

<p>Abstract</p> <p>Background</p> <p>Myocardial infarction is the combined result of environmental factors and personal predispositions. Prothrombotic factors might play an important role in this phenomenon. Annexin V (ANV) is a calcium-dependent glycoprotein widely present in various tissues exerting a potent anticoagulant effect in vitro by reducing plaque adhesion and aggregation. Anti-annexin V antibodies (aANVAs) are detected in various diseases like rheumatoid arthritis, systemic lupus erythematosus and anti-phospholipid antibody syndrome. The study of ANV in Acute Myocardial Infarction (AMI) might shed light on hypercoagulability mechanisms in the pathogenesis of acute coronary syndromes. This study was conducted to investigate the association of plasma ANV, aANVAs and anti-cardiolipin antibodies (aCLAs) with AMI.</p> <p>Methods</p> <p>This study recruited 45 patients with the diagnosis of AMI according to WHO criteria in their first 24 hours of admission. 36 matched individuals were studied as the control group with normal coronary artery angiography. Plasma levels of ANV, aANVAs and aCLAs were determined by enzyme-linked immunosorbent assay and the results were compared.</p> <p>Results</p> <p>Plasma ANV levels in the patients with AMI on admission were significantly lower than those in the control group (p = 0.002). Positive test for aANVAs were found to be present in a significant number of our patients (p = 0.004). The studied groups were similar in their rate of patients with positive aCLAs tests. ANV, aANVAs and aCLAs were not correlated with hypertension, diabetes mellitus, hyperlipidemia, sex, age and smoking.</p> <p>Conclusion</p> <p>Our findings suggest that low plasma ANV levels along with positive aANVAs tests in patients with AMI are indicative of hypercoagulable state that is not related to the traditional cardiovascular risk factors.</p

Preventing TMTO attack in AES-CCMP in IEEE 802.11i

This study is conducted to establish an alternative, creative technique for the structure of Advanced Encryption Standard-Counter Mode with Cipher Block Chaining Message Authentication Code Protocol (AES-CCMP) key in IEEE 802.11i. the structure of proposed method increase the length of AES-CCMP key from 128 bits to 256 bits to eliminate Time-Memory Trade-Off (TMTO) attacks by using three proposed solutions including Random Nonce Key, Four Way Handshake alteration and Pseudo Random Function (PRF). Besides, two proposed and classic methods are compared in terms of TMTO attack probability, avalanche effect, changes in neighbor blocks, memory usage and execution time. According to the results, the proposed method is completely resistant to TMTO attack. In addition, avalanche effect and change in neighbor blocks of proposed method are so near to optimized state and also, two classic and proposed methods are approximately the same in case of memory usage and execution time

Stress Cardiomyopathy (Takotsubo syndrome) Following Accidental Methadone Poisoning; Report of Two Pediatric Cases

Methadone poisoning has become more common in the pediatric population due to extensive use of methadone maintenance therapy (MMT). It is associated with decreased level of consciousness, coma, respiratory distress and cardiac intoxication. The cardiac complications have been reported to be QT prolongation, torsade de pointes, coronary artery disease, arrhythmia, stress cardiomyopathy and death. We herein report two pediatric patients with accidental methadone poisoning who developed stress cardiomyopathy and cardiac failure. The first case was a 4-yaer-old girl and the second one was an 18-month-old girl both being accidentally poisoned with methadone syrup and were brought with decreased level of consciousness. Both were diagnosed to suffer from congestive heart failure based on echocardiography. However, the first case passed away despite appropriate treatment, while the second one survived the condition and was discharged with good condition and was symptom free at 6-month follow-up

N-Acetylcysteine Overdose: A Case Report

Background: N-Acetylcysteine (NAC) is a cost-effective antioxidant and very useful treatment for several diseases. Methods: Here we report a rare case of iatrogenic NAC overdose following the mistake in calculation of the loading dose. Results: The patient was 14 years old girl referred to a local hospital due to history of intentional ingesting about 7grams acetaminophen. The physician prescribed her 6 grams NAC as a loading dose but 42grams NAC were infused by mistake. After infusion, the patient showed signs of anaphylactic shock and then transferred to Imam Reza toxicology-unite with weakness, lethargy, extreme fatigue, nausea, and dizziness. NAC overdosing, in a short period of time, led to coagulopathy, reduced platelet count, acute renal failure and metabolic acidosis. After 24 h, the patient died. The Medical forensic examination showed minor lung hemorrhage and presence of little amount of Aluminum phosphide in tissues they did not find no vital organ hemorrhage. It is unclear related to NAC overdose, phosphine intoxication or synergic effects. Conclusion: Massive transfusion of NAC was associated with impairment of coagulation factors, intracranial hypertension, renal failure and metabolic acidosis. Thus, NAC administration should be with caution. The medical history of patients committed suicide are not always accurate and complete evaluation are recommended

Single left coronary artery with origin of right coronary artery from left circumflex: a case report

which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Background: A 40-years-old female presented with intermittent chest pain and dyspnea on exertion. Case Presentation: Electrocardiography showed sinus rhythm with ST-depression in inferior and lateral leads. Subsequent exercise treadmill testing revealed significant ST-depression in V4–V5 and V6 leads. Coronary angiography later showed a single left coronary artery with right coronary artery arising from left circumflex artery, a rare anomaly of coronary arteries. No atheromatous lesion was seen during angiography. Conclusion: The dignosis of this anomaly is importsnt because the symptoms cannot be differentiated from atherosclerotic coronary artery disease. Case presentation A 40-years-old female was admitted to the hospital with intermittent substernal chest pain and dyspnea. She visited our outpatient clinic because of exacerbation o

Impact of Wikipedia on citation trends

It has been suggested that the "visibility" of an article influences its citation count. More specifically, it is believed that the social media can influence article citations.Here we tested the hypothesis that inclusion of scholarly references in Wikipedia affects the citation trends. To perform this analysis, we introduced a citation “propensity” measure, which is inspired by the concept of amino acid propensity for protein secondary structures. We show that although citation counts generally increase during time, the citation "propensity" does not increase after inclusion of a reference in Wikipedia