Thermal transport at a nanoparticle-water interface: A molecular dynamics and continuum modeling study

Heat transfer between a silver nanoparticle and surrounding water has been studied using molecular dynamics (MD) simulations. The thermal conductance (Kapitza conductance) at the interface between a nanoparticle and surrounding water has been calculated using four different approaches: transient with/without temperature gradient (internal thermal resistance) in the nanoparticle, steady-state non-equilibrium and finally equilibrium simulations. The results of steady-state non-equilibrium and equilibrium are in agreement but differ from the transient approach results. MD simulations results also reveal that in the quenching process of a hot silver nanoparticle, heat dissipates into the solvent over a length-scale of ~ 2nm and over a timescale of less than 5ps. By introducing a continuum solid-like model and considering a heat conduction mechanism in water, it is observed that the results of the temperature distribution for water shells around the nanoparticle agree well with MD results. It is also found that the local water thermal conductivity around the nanoparticle is greater by about 50 percent than that of bulk water. These results have important implications for understanding heat transfer mechanisms in nanofluids systems and also for cancer photothermal therapy, wherein an accurate local description of heat transfer in an aqueous environment is crucial.Comment: 22 pages, 7 figures

Lattice Bisognano-Wichmann modular Hamiltonian in critical quantum spin chains

We carry out a comprehensive comparison between the exact modular Hamiltonian and the lattice version of the Bisognano-Wichmann (BW) one in one-dimensional critical quantum spin chains. As a warm-up, we first illustrate how the trace distance provides a more informative mean of comparison between reduced density matrices when compared to any other Schatten n-distance, normalized or not. In particular, as noticed in earlier works, it provides a way to bound other correlation functions in a precise manner, i.e., providing both lower and upper bounds. Additionally, we show that two close reduced density matrices, i.e. with zero trace distance for large sizes, can have very different modular Hamiltonians. This means that, in terms of describing how two states are close to each other, it is more informative to compare their reduced density matrices rather than the corresponding modular Hamiltonians. After setting this framework, we consider the ground states for infinite and periodic XX spin chain and critical Ising chain. We provide robust numerical evidence that the trace distance between the lattice BW reduced density matrix and the exact one goes to zero as \u2113 122 for large length of the interval \u2113. This provides strong constraints on the difference between the corresponding entanglement entropies and correlation functions. Our results indicate that discretized BW reduced density matrices reproduce exact entanglement entropies and correlation functions of local operators in the limit of large subsystem sizes. Finally, we show that the BW reduced density matrices fall short of reproducing the exact behavior of the logarithmic emptiness formation probability in the ground state of the XX spin chain

Pain Management in the Emergency Department: a Review Article on Options and Methods

Context: The aim of this review is to recognizing different methods of analgesia for emergency medicine physicians (EMPs) allows them to have various pain relief methods to reduce pain and to be able to use it according to the patient’s condition and to improve the quality of their services. Evidence acquisition: In this review article, the search engines and scientific databases of Google Scholar, Science Direct, PubMed, Medline, Scopus, and Cochrane for emergency pain management methods were reviewed. Among the findings, high quality articles were eventually selected from 2000 to 2018, and after reviewing them, we have conducted a comprehensive comparison of the usual methods of pain control in the emergency department (ED).  Results: For better understanding, the results are reported in to separate subheadings including “Parenteral agents” and “Regional blocks”. Non-opioids analgesics such as nonsteroidal anti-inflammatory drugs (NSAIDs) and acetaminophen are commonly used in the treatment of acute pain. However, the relief of acute moderate to severe pain usually requires opioid agents. Considering the side effects of systemic drugs and the restrictions on the use of analgesics, especially opioids, regional blocks of pain as part of a multimodal analgesic strategy can be helpful. Conclusion: This study was designed to investigate and identify the disadvantages and advantages of using each drug to be able to make the right choices in different clinical situations for patients while paying attention to the limitations of the use of these analgesic drugs

Enhanced Interfacial Thermal Conductance between Charged Nanoparticle and Aqueous Electrolyte

Heat transfer through the interface between a metallic nanoparticle and an electrolyte solution, has great importance in a number of applications, ranging from nanoparticle-based cancer treatments to nanofluids and solar energy conversion devices. However, the impact of surface charge and the dissolved ions on heat transfer has been scarcely explored so far. In this study, we compute the interface thermal conductance between hydrophilic and hydrophobic charged gold nanoparticles immersed in an electrolyte using equilibrium molecular dynamics simulations. Compared with an uncharged nanoparticle, we report a threefold increase of the Kapitza conductance for a nanoparticle surface charge +2 e/nm2. This enhancement is shown to be approximately independent of surface wettability, charge spatial distribution, and salt concentration. This allows us to express the Kapitza conductance enhancement in terms of surface charge density on a master curve. Finally, we interpret the increase of the Kapitza conductance as a combined result of a shift in the water density distribution toward the charged nanoparticle and an accumulation of the counter-ions around the nanoparticle surface which increase the Coulombic interaction between the liquid and the charged nanoparticle

Pain Management in the Emergency Department: a Review Article on Options and Methods

Context: The aim of this review is to recognizing different methods of analgesia for emergency medicine physicians (EMPs) allows them to have various pain relief methods to reduce pain and to be able to use it according to the patient’s condition and to improve the quality of their services. Evidence acquisition: In this review article, the search engines and scientific databases of Google Scholar, Science Direct, PubMed, Medline, Scopus, and Cochrane for emergency pain management methods were reviewed. Among the findings, high quality articles were eventually selected from 2000 to 2018, and after reviewing them, we have conducted a comprehensive comparison of the usual methods of pain control in the emergency department (ED).  Results: For better understanding, the results are reported in to separate subheadings including “Parenteral agents” and “Regional blocks”. Non-opioids analgesics such as nonsteroidal anti-inflammatory drugs (NSAIDs) and acetaminophen are commonly used in the treatment of acute pain. However, the relief of acute moderate to severe pain usually requires opioid agents. Considering the side effects of systemic drugs and the restrictions on the use of analgesics, especially opioids, regional blocks of pain as part of a multimodal analgesic strategy can be helpful. Conclusion: This study was designed to investigate and identify the disadvantages and advantages of using each drug to be able to make the right choices in different clinical situations for patients while paying attention to the limitations of the use of these analgesic drugs

Evaluation of acute renal failure in neonates bedridden in Neonatal Intensive Care Unite (NICU) in Ghaem hospital

چکیده: زمینه و هدف: نارسایی حاد کلیه بصورت یک کاهش ناگهانی شدید در GFR (Glomerular Filtration Rate) تعریف شده است و در بخش نوزادان شایع می باشد. این مطالعه با هدف بررسی انسیدانس، اتیولوژی، شیوه افتراق انواع نارسایی کلیه در نوزادان انجام شد. روش بررسی: در یک مطالعه توصیفی، 750 نوزاد بستری شده در بخش مراقبت های ویژه نوزادان بیمارستان قائم(عج) مشهد، از دی ماه 1384 تا دی ماه 1385، با تشخیص نارسایی کلیوی و بر اساس سونوگرافی و پاسخ به مایع درمانی به دو گروه رنال و پره نال تقسیم بندی شدند. این نوزادان از نظر ریسک فاکتورهای پره ناتال، پری ناتال، پست ناتال ریسک فاکتورهای مادری و محیطی و اندکس های مختلف سرمی و ادراری بررسی و داده ها به کمک آمار توصیفی تحلیل شدند. یافته ها: از 750 بیمار پذیرش شده 38 نوزاد (5) تشخیص نارسایی کلیوی داشتند، که 29 نفر (4/76) نارسایی پره رنال و 9 نفر (6/23) نارسایی رنال داشتند. فاکتورهای مستعد کننده همراه با نارسایی کلیوی شامل آسفیکسی (42)، سندرم غشا هیالن مامبران ((RDS (7/26)، سپسیس (13)، دهیدراتاسیون شدید (13) و بیماری مادرزادی قلبی (2/5) بودند. نتیجه گیری: نارسایی حاد کلیه یک علت مهم مرگ در نوزادان می باشد. شناسایی فاکتورهای مستعد کننده مثل نارس بودن، آسفیکسی، RDS، ونتیلاسیون و کنترل دقیق وضعیت کلیه های نوزادان در این شرایط ضروری است. پیش آگهی نوع پره رنال در صورت مایع درمانی مناسب، خوب بوده ولی در نوع رنال پیش آگهی وابسته به بیمار زمینه‌ای می باشد و مرگ و میر بالاست

Management of Violence and Aggression in Emergency Environment; a Narrative Review of 200 Related Articles

Context: The aim of this study is to reviewing various approaches for dealing with agitated patients in emergency department (ED) including of chemical and physical restraint methods. Evidence acquisition: This review was conducted by searching “Violence,” “Aggression,” and “workplace violence” keywords in these databases: PubMed, Scopus, EmBase, ScienceDirect, Cochrane Database, and Google Scholar. In addition to using keywords for finding the papers, the related article capability was used to find more papers. From the found papers, published papers from 2005 to 2018 were chosen to enter the paper pool for further review. Results: Ultimately, 200 papers were used in this paper to conduct a comprehensive review regarding violence management in ED. The results were categorized as prevention, verbal methods, pharmacological interventions and physical restraint. Conclusion: In this study various methods of chemical and physical restraint methods were reviewed so an emergency medicine physician be aware of various available choices in different clinical situations for agitated patients

The Effect of Mentoring Novice Clinical Educators on the Perception of Nursing Students from the Clinical Learning Environment

Introduction: Creating a supportive clinical learning environment (CLE) is one of the characteristics of an effective clinical instructor in nursing. Perhaps empowering novice clinical educators using mentorship method can reduce or resolve this problem. The aim of this study was to determine the impact of the mentorship program for novice clinical educators on the nursing students’ actual and preferred understanding of CLE.Methods: This quasi-experimental study on three groups was conducted as post-intervention with the participation of 139 undergraduate nursing students of Mashhad University of Medical Sciences. Sampling was done via stratified and multistage method. Students were placed in three groups: expert clinical educator (n=47), novice clinical educator (n=51), and mentorship (n=41). In the novice and expert clinical educator groups, training was conducted through the conventional method. In the mentorship group, a novice clinical educator (mentee) and an expert clinical educator (mentor) had a mentoring relationship for two weeks. The Chan (2001) CLE inventory was completed at the end of the first and second weeks of externship. Data were analyzed through SPSS v. 16 software using one-way ANOVAand paired t-tests.Results: The students of the three groups were homogeneous in terms of gender (P=0.101) and level of interest in the field (P=0.278). According to the result of the paired t-test, the difference in the mean score of the actual and preferred CLE at the end of the first week was statistically significant in the novice clinical educators (P=0.008) and the mentorship group (P=0.04); however, after the implementation of mentorship program (at the end of the second week), the difference was significant only in the novice educators group (P=0.001).Conclusion: The implementation of the mentorship program for novice clinical educators (as with the expert educators group) could lead to a reduction in the mismatch between the actual and preferred views of students about the CLE. Thus, it is recommended that this method should be used under conditions of shortage of expert educators to create a supportive CLE

Possibility of the pond culture of Asian sea bass, lates calcarifer in Gwadar farm , Sistan & Baloochestan

In the present study, the possibility of marine culture of Asian sea bass in the shrimp earthen ponds located in the Gwadar region (coastal area of Oman Sea, southeastern of Iran) was investigated. To this end, Asian sea bass frys reared for 7 months including 1 month nursery and 6 months growth-period. During the culturing periods, fish were feed ad libitum by various commercial rainbow trout diets based on fish growth stages. After nursery period, the average weight of 11.05±1.5 g and survival percent of 65 % were obtained for fish. During the growth-out period, the average weight increased continually from 31.4±4.7 g in late June to 252.1±30 g at the end of growth-out period in late Dec. Also, the highest values of monthly weight gain yielded during August, Sept and Oct when fish had the average weight range of (76.9±14.4)-(188.1±12.8) g. The values of monthly feed conversion ratio (FCR) were low and similar from July to Oct and then increased in Nov and Dec. The values of total monthly feed intake (FI) increased continually from July to Oct and then with a decrease in Nov, increased again in Dec. The values of survival percent after nursery and growth-out period were 65 % and 66% respectively. Also, the average of monthly FCR, FCR at the time of fish harvesting, total FI and total harvested biomass were 1.36, 2.5, 630.5 kg and 325 kg. in conclusion, the pond culture of Asian sea bass with marine water results appropriate survival and growth rates so that fish (11.05±1.5 g) obtained marketable weight (252.1±30 g) during 6 months culturing period. It seems that first-half of year in Gwadar area is more suitable for sea bass culture since this time periods results better FCR ( fed by rainbow trout feed) and has economic justification. Also, with regular sorting operation and providing of species-specific feed for Asian sea bass can increase the Production per Unit Area

Clinical Breast Cancer Registry of IR. Iran (CBCR-IR):Study Protocol and First Results

BACKGROUND: Breast cancer (BC), as a significant global health problem, is the most common cancer in women. Despite the importance of clinical cancer registries in improving the quality of cancer care and cancer research, there are few reports on them from low- and middle-income countries. We established a multicenter clinical breast cancer registry in Iran (CBCR-IR) to collect data on BC cases, the pattern of care, and the quality-of-care indicators in different hospitals across the country.METHODS: We established a clinical cancer registry in 12 provinces of Iran. We defined the organizational structure, developed minimal data sets and data dictionaries, verified data sources and registration processes, and developed the necessary registry software. During this registry, we studied the clinical characteristics and outcomes of patients with cancer who were admitted from 2014 onwards.RESULTS: We registered 13086 BC cases (7874 eligible cases) between 1.1.2014 and 1.1.2022. Core needle biopsy from the tumor (61.25%) and diagnostic mammography (68.78%) were the two most commonly used diagnostic methods. Stage distribution was 2.03% carcinoma in situ, 12% stage I, 44.65% stage II, 21.32% stage III, and 4.61% stage IV; stage information was missing in 1532 patients (19.46%). Surgery (95.01%) and chemotherapy (79.65%) were the most common treatments for all patients.CONCLUSION: The information provided by this registry can be used to evaluate and improve the quality of care for BC patients. It will be scaled up to the national level as an important resource for measuring quality of care and conducting clinical cancer research in Iran.</p