A Geometric Model for the Coiling of an Elastic Rod Deployed Onto a Moving Substrate

We report results from a systematic numerical investigation of the nonlinear patterns that emerge when a slender elastic rod is deployed onto a moving substrate; a system also known as the elastic sewing machine (ESM). The discrete elastic rods (DER) method is employed to quantitatively characterize the coiling patterns, and a comprehensive classification scheme is introduced based on their Fourier spectrum. Our analysis yields physical insight on both the length scales excited by the ESM, as well as the morphology of the patterns. The coiling process is then rationalized using a reduced geometric model (GM) for the evolution of the position and orientation of the contact point between the rod and the belt, as well as the curvature of the rod near contact. This geometric description reproduces almost all of the coiling patterns of the ESM and allows us to establish a unifying bridge between our elastic problem and the analogous patterns obtained when depositing a viscous thread onto a moving surface; a well-known system known as the fluid-mechanical sewing machine (FMSM).National Science Foundation (U.S.) (CMMI-1129894

Propulsion and Instability of a Flexible Helical Rod Rotating in a Viscous Fluid

We combine experiments with simulations to investigate the fluid-structure interaction of a flexible helical rod rotating in a viscous fluid, under low Reynolds number conditions. Our analysis takes into account the coupling between the geometrically nonlinear behavior of the elastic rod with a nonlocal hydrodynamic model for the fluid loading. We quantify the resulting propulsive force, as well as the buckling instability of the originally helical filament that occurs above a critical rotation velocity. A scaling analysis is performed to rationalize the onset of this instability. A universal phase diagram is constructed to map out the region of successful propulsion and the corresponding boundary of stability is established. Comparing our results with data for flagellated bacteria suggests that this instability may be exploited in nature for physiological purposes.National Science Foundation (U.S.) (CMMI-1129894

Lessons and implications from a mass immunization campaign in squatter settlements of Karachi, Pakistan: an experience from a cluster-randomized double-blinded vaccine trial [NCT00125047]

OBJECTIVE: To determine the safety and logistic feasibility of a mass immunization strategy outside the local immunization program in the pediatric population of urban squatter settlements in Karachi, Pakistan. METHODS: A cluster-randomized double blind preventive trial was launched in August 2003 in 60 geographic clusters covering 21,059 children ages 2 to 16 years. After consent was obtained from parents or guardians, eligible children were immunized parenterally at vaccination posts in each cluster with Vi polysaccharide or hepatitis A vaccine. Safety, logistics, and standards were monitored and documented. RESULTS: The vaccine coverage of the population was 74% and was higher in those under age 10 years. No life-threatening serious adverse events were reported. Adverse events occurred in less than 1% of all vaccine recipients and the main reactions reported were fever and local pain. The proportion of adverse events in Vi polysaccharide and hepatitis A recipients will not be known until the end of the trial when the code is broken. Throughout the vaccination campaign safe injection practices were maintained and the cold chain was not interrupted. Mass vaccination in slums had good acceptance. Because populations in such areas are highly mobile, settlement conditions could affect coverage. Systemic reactions were uncommon and local reactions were mild and transient. Close community involvement was pivotal for information dissemination and immunization coverage. CONCLUSION: This vaccine strategy described together with other information that will soon be available in the area (cost/effectiveness, vaccine delivery costs, etc) will make typhoid fever control become a reality in the near future

Deformation of a soft helical filament in an axial flow at low Reynolds number

We perform a numerical investigation of the deformation of a rotating helical filament subjected to an axial flow, under low Reynolds number conditions, motivated by the propulsion of bacteria using helical flagella. Given its slenderness, the helical rod is intrinsically soft and deforms due to the interplay between elastic forces and hydrodynamic loading. We make use of a previously developed and experimentally validated computational tool framework that models the elasticity of the filament using the discrete elastic rod method and the fluid forces are treated using Lighthill's slender body theory. Under axial flow, and in the absence of rotation, the initially helical rod is extended. Above a critical flow speed its configuration comprises a straight portion connected to a localized helix near the free end. When the rod is also rotated about its helical axis, propulsion is only possible in a finite range of angular velocity, with an upper bound that is limited by buckling of the soft helix arising due to viscous stresses. A systematic exploration of the parameter space allows us to quantify regimes for successful propulsion for a number of specific bacteria

A Geometric Model for the Coiling of an Elastic Rod Deployed Onto a Moving Substrate

We report results from a systematic numerical investigation of the nonlinear patterns that emerge when a slender elastic rod is deployed onto a moving substrate; a system also known as the elastic sewing machine (ESM). The discrete elastic rods (DER) method is employed to quantitatively characterize the coiling patterns, and a comprehensive classification scheme is introduced based on their Fourier spectrum. Our analysis yields physical insight on both the length scales excited by the ESM, as well as the morphology of the patterns. The coiling process is then rationalized using a reduced geometric model (GM) for the evolution of the position and orientation of the contact point between the rod and the belt, as well as the curvature of the rod near contact. This geometric description reproduces almost all of the coiling patterns of the ESM and allows us to establish a unifying bridge between our elastic problem and the analogous patterns obtained when depositing a viscous thread onto a moving surface; a well-known system known as the fluid-mechanical sewing machine (FMSM)

Untangling the Mechanics and Topology in the Frictional Response of Long Overhand Elastic Knots

We combine experiments and theory to study the mechanics of overhand knots in slender elastic rods under tension. The equilibrium shape of the knot is governed by an interplay between topology, friction, and bending. We use precision model experiments to quantify the dependence of the mechanical response of the knot as a function of the geometry of the self-contacting region, and for different topologies as measured by their crossing number. An analytical model based on the nonlinear theory of thin elastic rods is then developed to describe how the physical and topological parameters of the knot set the tensile force required for equilibrium. Excellent agreement is found between theory and experiments for overhand knots over a wide range of crossing numbers

Propulsion and Instability of a Flexible Helical Rod Rotating in a Viscous Fluid

We combine experiments with simulations to investigate the fluid-structure interaction of a flexible helical rod rotating in a viscous fluid, under low Reynolds number conditions. Our analysis takes into account the coupling between the geometrically nonlinear behavior of the elastic rod with a nonlocal hydrodynamic model for the fluid loading. We quantify the resulting propulsive force, as well as the buckling instability of the originally helical filament that occurs above a critical rotation velocity. A scaling analysis is performed to rationalize the onset of this instability. A universal phase diagram is constructed to map out the region of successful propulsion and the corresponding boundary of stability is established. Comparing our results with data for flagellated bacteria suggests that this instability may be exploited in nature for physiological purposes

Form finding in elastic gridshells

Elastic gridshells comprise an initially planar network of elastic rods that are actuated into a shell-like structure by loading their extremities. The resulting actuated form derives from the elastic buckling of the rods subjected to inextensibility. We study elastic gridshells with a focus on the rational design of the final shapes. Our precision desktop experiments exhibit complex geometries, even from seemingly simple initial configurations and actuation processes. The numerical simulations capture this nonintuitive behavior with excellent quantitative agreement, allowing for an exploration of parameter space that reveals multistable states. We then turn to the theory of smooth Chebyshev nets to address the inverse design of hemispherical elastic gridshells. The results suggest that rod inextensibility, not elastic response, dictates the zeroth-order shape of an actuated elastic gridshell. As it turns out, this is the shape of a common household strainer. Therefore, the geometry of Chebyshev nets can be further used to understand elastic gridshells. In particular, we introduce a way to quantify the intrinsic shape of the empty, but enclosed regions, which we then use to rationalize the nonlocal deformation of elastic gridshells to point loading. This justifies the observed difficulty in form finding. Nevertheless, we close with an exploration of concatenating multiple elastic gridshell building blocks.National Science Foundation (U.S.) (Grant CMMI-1351449