Changed mitochondrial enzymes activity in alzheimer’s diseas: a systematic review and meta-analysis

Thus far, a substantial body of research has demonstrated significant abnormalities in mitochondria within the brain of individuals diagnosed with Alzheimer's disease.(8) In line with the finding that compromised energy metabolism consistently occurs before the clinical manifestation of Alzheimer's disease (AD), it has been firmly shown that mitochondrial dysfunction is an early and conspicuous characteristic of the disease. This indicates that mitochondrial dysfunction likely plays a crucial role in the development of AD. In the present study, we investigated correlations of the activity of several enzymes such as Choline acetyltransferase (ChAT), an example of a transmitter-related enzyme and the distribution of KGDHC, a mitochondrial factor that is very deficient in AD, and also other aforementioned enzymes such GDH, PDHC, and Citrate synthase in the brain of our specimen from temporal lobe and parietal lobe in AD and control Subjects.(8) To our knowledge, this study is the first of its kind to conduct a meta-analysis on the changed enzymatic activity of mitochondria in relation to Alzheimer’s disease and to report the corresponding changes

Psychedelic therapy in individuals with eating disorders: a systematic review and meta-analysis

Conventional psychedelics have the potential to exhibit transdiagnostic effectiveness by engaging in many pathways that are pertinent to the pathophysiology of eating disorders. The demand for PAT is considerable, as are the attempts to make it more widely available. Early clinical studies are focusing on determining the effectiveness and usefulness of this therapy for eating disorders, although safety is yet unknown. Recent research indicates that Psychodynamic Art Therapy (PAT) may have the capacity to enhance the effectiveness of existing therapies for this challenging and resistant condition. The current body of evidence supporting the use of PAT for individuals with eating disorders is limited in terms of its quality and validity. Therefore, our objective was to do a comprehensive review and meta-analysis to assess the effectiveness of PAT, using the existing data