Synthesis, Molecular Modeling, and Biological Evaluation of New N-(Benzo[d]thiazol-2-yl)-3-amino-but-2-enamide Derivatives as Cytotoxic Agents

Synthesis, Molecular Modeling, and Biological Evaluation of New N-(Benzo[d]thiazol-2-yl)-3-amino-but-2-enamide Derivatives as Cytotoxic Agent

A New Approach to the Ring-Opening of Epoxides under Mild and Green Conditions

In this research work, we have designed and introduced [Zr-UiO-66-CO2H]Br as a versatile heterogeneous acid catalyst for the ring-opening of epoxides through SN1 and/or SN2 type mechanisms. In addition, the appropriate method for designing an active and efficient Bronsted acid site in metal-organic frameworks is discussed. [Zr-UiO-66-CO2H]Br was applied for the preparation of α-aryloxy alcohols by the condensation reaction of various epoxides with phenol or thiophenols under mild and green conditions.</p