Different theoretical ADMET characters of the tested compounds.

Different theoretical ADMET characters of the tested compounds.</p

Selectivity indices of the synthesized compounds.

Selectivity indices of the synthesized compounds.</p

The docked pose of 14a against VEGFR-2.

The docked pose of 14a against VEGFR-2.</p

IC₅₀ results of 10a, b and 14a-c against Vero cell line.

IC50 results of 10a, b and 14a-c against Vero cell line.</p

Chemical structure of compound 14c.

Chemical structure of compound 14c.</p

The design rationale of proposed VEGFR-2 inhibitors.

The design rationale of proposed VEGFR-2 inhibitors.</p

The docked pose of sorafenib against VEGFR-2.

The docked pose of sorafenib against VEGFR-2.</p

Fig 12 -

A) RMSF B) Rg C) SASA of VEGFR-2 enzyme in apo state.</p

The colors, yields, and meting points of the new compounds.

The colors, yields, and meting points of the new compounds.</p

Synthesis of compounds 10a-b.

Synthesis of compounds 10a-b.</p