Effect of diabetes (DV) and different oral drug regimens on the serum lipid profile.

<p>Effect of diabetes (DV) and different oral drug regimens, viz., phytol (DP_h, 250 mg/kg); pioglitazone (DP₅, 5 mg/kg); pioglitazone (DP₁₀, 10 mg/kg); phytol and pioglitazone (DP_hP₅); on serum levels of triglycerides, total cholesterol, LDL-C, HDL-C, ALT and TC/HDL ratio (mean of 7 animals ± S.D). As compared with non-diabetic [ND] (*) and diabetic [DV] (#) groups using one way ANOVA followed by Tukey post hoc test, <i>P</i><0.05. (^Ο) Significant interaction when P_h and P₅ were combined using Factorial Design.</p

Effect of diabetes (DV) and different oral drug regimens on glucose homeostasis indicators.

<p>Effect of diabetes (DV) and different oral drug regimens, viz., phytol (DP_h, 250 mg/kg); pioglitazone (DP₅, 5 mg/kg); pioglitazone (DP₁₀, 10 mg/kg); phytol and pioglitazone (DP_hP₅); on serum levels of glucose, insulin, fructosamine, TNF-α, adiponectin and insulin resistance (HOMA-ratio) (mean of 7 animals ± S.D). As compared with non-diabetic [ND] (*) and diabetic [DV] (#) groups using one way ANOVA followed by Tukey post hoc test, <i>P</i><0.05. (^Ο) Significant interaction when P_h and P₅ were combined using Factorial Design.</p

ICM scores of phytanic acid, retinoic acid, pioglitazone, and rosiglitazone docked in 1FM6 crystal structure binding site and hydrogen bonds formed with amino acid residues.

<p>ICM scores of phytanic acid, retinoic acid, pioglitazone, and rosiglitazone docked in 1FM6 crystal structure binding site and hydrogen bonds formed with amino acid residues.</p

Correlation coefficient (<i>r</i>) between serum glucose, insulin and HOMA-R with TNF-α, adiponectin, ALT and visceral fat weight/body weight ratio.

<p>Correlation was carried out in untreated and treated hyperglycemic animals only.</p

Effect of STZ (35 mg/kg, i.p.) on NPD -fed rats.

<p>Values are means±SD; NPD: Normal pellet diet.</p