Convenient Synthesis of Some New Bi-heterocycles conataining 3-Aminoquinazolin-4(3H)-one and 1,2,4-Triazole moieties

Dicarboxylic acids, thiosemicarbazides and methylanthranilate reacted to give methyl-2-(3-(5-mercapto-4-s-1,2,4-triazol-3-yl)-3-oxoalkylamino)benzoates 4. The laters, cyclized with hydrazine hydrate to give 3-amino-2-((5-mercapto-4 substitued-1,2,4-triazol-3-yl)alkyl)quinazolin-4(3H)-ones 5 which expected to have biological effects

New Benzoxazole Derivatives as Antiprotozoal Agents: In Silico Studies, Synthesis, and Biological Evaluation

Background. Benzoxazole derivatives have different biological activities. In pursuit of designing novel chemical entities with antiprotozoal and antimicrobial activities, benzoxazolyl aniline was utilized as a privileged scaffold of a series of (3-benzoxazole-2-yl) phenylamine derivatives, 3-benzoxazoloyl acetamide, and butyramide derivatives. Methods. These novel analogs were synthesized in straightforward simple chemistry without any quantitative chromatographic separations in reasonable yields. The biological evaluation of all target compounds as potential antimalarial, antileishmanial, antitrypanosomal, and antimicrobial agents was performed by various well-established cell-based methods. Results. Compounds 6d and 5a showed promising biological screening data. The amidation of 3-benzoxazolyl aniline 1 with the chloroacetyl functional group resulted in a good antimalarial activity and showed moderate inhibitory activities against leishmanial and trypanosomal spp. Moreover, chloroacetyl functionalization of benzoxazolyl aniline serves as a good early goal for constructing and synthesizing new antimicrobial and antiprotozoal agents. The molecular docking study rationalizes the relative inhibitory activity of compound 5a as an antimalarial agent with the deregulation of PfPNP activity which has emerged as a major mechanism of these targets

Sacrococcygeal teratoma excision: a vertical rather than transverse wound closure

Background: The chevron incision has been the standard approach for sacrococcygeal teratoma (SCT) excision. Here, we are reporting our experience of shifting to the vertical posterior sagittal approach.Patients and methods: During the period 2011 through 2016, we operated on 17 (16 female and one male) cases of SCT. Their age at presentation ranged from day 1 to 26 months (mean=4.8 months, median=2 months). The chevron incision was used in five, whereas the vertical posterior sagittal approach was used in 12 patients.Results: In this series, we had one case of perioperative mortality, in addition to another case of perineal wound disruption (in the group of vertical wound closure), which was managed conservatively (to heal by secondary intention) with a very satisfactory hidden scar at 6-month follow-up. Overall, we did not find the vertical approach to add any extra limitations to the surgical exposure or dissection; meanwhile, it provided a well-recognized cosmetic advantage.Conclusion: The vertical posterior sagittal approach for excision of SCT is both feasible and advantageous in terms of the cosmetic outcome. It provides a well-hidden scar in the natal cleft and preserves normal contouring of the buttocks.Keywords: buttock, cosmesis, posterior sagittal, reconstruction, sacrococcygeal teratom

EXTRACTION, FRACTIONATION AND CHARACTERIZATION OF COWPEA (VIGNA UNGUICULATA) GLOBULINS

The proteins were extracted from cowpea seeds by buffered saline solution and the globulins were separated by dialyzing the protein extract against distilled water. Fractionation of the total globulins on Sephacryl S-200 column produced two major and one minor components. The molecular weight of the major globulin components were estimated to be greater than 250000 and 178 000 for the globulin component (a) and (b) respectively and the latter component was the predominant globulin. The two major globulin components were free from contamination of other proteins as shown by polyacrylamide gel electrophoresis. Spectrophotometry and amino acid analyses were used as tools for characterizing the globulin components

Effect of FSW Parameters on The Microstructure and Mechanical Properties of T-joints between Dissimilar Al-Alloys

The main purpose of this research is to develop T-joints between the aluminum AA 2024-T4 and AA 7075-T6 using friction stir welding.  The effect of tool geometries, tool traveling speed, and rotational rate in the welded T-joints were investigated and discussed. Three different tools were used with different shoulder to pin ratios 3.28, 3.36, and 4.31. After optimization, the best tool dimension has used with the different rotational and welding speeds. Three tool traverse speeds of 50, 75, and 100 mm/min were used. Two rotation rates of 800 rpm and 1000 rpm were applied. After FSW, at a number of the above FSW parameters' combinations, macrostructure and microstructure analyses were done using optical microscopy. In order to have an insight into the mechanical properties, hardness measurements and tensile testing were carried out. Using small shoulder to pin ratio produced visually unacceptable T-joint. Opposite happened by using the tool with 4.31 of shoulder to pin ratio. Furthermore, the results showed sound T-welds with no obvious defects at high rotational rate of 1000 rpm with the two used traveling speeds. Asymmetric temperature distribution was observed between the two sides, advance side (AS) and retreating side (RS