3 research outputs found
Tamoxifen Use and Gallstone Formation in Postmenopausal Breast Cancer Patients in South Indian Population
Background: Tamoxifen is being used in patients with estrogen receptor
positive breast cancer as an adjuvant or palliative hormonal therapy.
Western studies have found a 30% incidence of gallstones in patients
who are taking Tamoxifen and they have proved a significant association
between the two. Objectives : The objective of the study was to find
out the association of Tamoxifen use and gallstone formation in
postmenopausal breast cancer patients in a South Indian population.
Methods: Ninety patients who had undergone surgery for invasive breast
cancer in our institute, and were receiving adjuvant Tamoxifen, were
recruited for the study. An equal number of age-matched postmenopausal
women were taken as controls. All of them underwent an abdominal
ultrasound screening test for gallstones. Presence or absence of
gallstones was noted down from their ultrasound scan reports.
Pretreatment status of the gall bladder was assessed from the
preoperative scan reports. Results: An odds ratio of 1 was derived
when the case group was compared with the control group. Conclusions:
In our study we could not establish that an association existed between
Tamoxifen use and gallstone formation in postmenopausal South Indian
women