Clinical Correlates of Carotid Artery Atherosclerosis in African Americans: Ethnic and Geographic Disparities

Abstract: Objectives: We evaluated whether carotid intima-media thickness (CIMT) and the presence or absence of plaque improved coronary heart disease (CHD) risk prediction when added to traditional risk factors. Background: Traditional cardiovascular disease (CVD) risk prediction schemes need further improvement as the majority of the CVD events occur in the intermediate risk groups. On an ultrasound scan, CIMT and presence of plaque are associated with CVD, and therefore could potentially help improve CHD risk prediction. Methods: Risk prediction models (overall, and in men and women) considered included traditional risk factors (TRF) only, TRF plus CIMT, TRF plus plaque, and TRF plus CIMT plus plaque presence. Predictivity was established by calculating the area under the curve (AUC). Cox proportional hazards models were used to estimate 10-year CHD risk for each risk model. Observed events were compared with expected events, and, the net reclassification index (NRI) was calculated. Results: Overall, the CIMT plus TRF plus plaque model provided the most improvement in AUC in the overall sample. Similarly, the CIMT plus TRF plus plaque model had the best net reclassification index of 9.9% in the overall population. However, comparison of TRF and CIMT and plaque with TRF and CIMT or TRF and plaque only resulted in statistically non-significant changes of the statistical test. Conclusions: Adding plaque and CIMT to TRF improve CHD risk prediction in the Jackson Heart Study (JHS). We hope that our study will shed further light on which patients to identify for further risk factor modification and or medical treatment and further intervention to reduce the burden of cardiovascular disease, and its overall impact in our population.Master of Public Healt

Insights in fundamental scratch behavior of polymeric materials

This work is mainly focused upon the analytical examination of the physical and mechanical response of plastics undergoing an induced scratch deformation caused by a semi-spherical scratch tip under a linearly increasing normal load. Evaluation of the scratch deformations in this study was based upon visual and optical observations and upon observations of failure and fracture mechanisms as well as Electron Microscopy examinations. In the first section of this study an effort was made to correlate the scratch resistance observed in Polypropylene (PP) thin sheets with material properties, such as molecular weight and surface crystallinity. In the second section of this work the scratch behavior of epoxy nanocomposites was examined and a conclusion was made based upon the effects of the addition of nano-additives with various natures into the epoxy matrix. Furthermore, a region of the scratch path prior to the onset of scratch visibility known as the mar region, which was an obscure area of deformation on a microscopic scale, was thoroughly investigated for the epoxy systems and various conclusions were made based upon those results. Finally, based on these findings and previous studies, it was shown that failure and fracture mechanisms of polymeric materials under scratch deformations are dependent on the type and physical nature of the material, whereas brittle and ductile materials show various behaviors under the specified conditions. Based on the failure mechanism which the material exhibits subsequent to the scratch deformation process and the physical and mechanical characteristics of the material, several factors were shown to effect the materials ability to scratch resistance

Mechanical, thermal and tribological properties of polyimide/nano-SiO2 composites synthesized using an in-situ polymerization

Polyimide (PI)/nano-SiO2 composites were successfully fabricated via a novel in-situ polymerization. Microstructure, thermal properties, mechanical performance and tribological behaviors of these composites were investigated. The results indicate that nano-SiO2 dispersed homogeneously. Compared with pure PI, thermal stability and heat resistance are higher about 10 °C with the addition of 5 wt% nano-SiO2. Compressive strength and modulus of composite with 5 wt% nano-SiO2 increase by 42.6 and 45.2%, respectively. The coefficient of friction (COF) of composite with 5 wt% nano-SiO2 decrease by 6.8% owing to the thick and uniform transfer films. Excess nano-SiO2 could adversely affect the COF of PI/nano-SiO2 composite. Additionally, wear resistance deteriorates obviously since transfer film exfoliates easily and nano-SiO2 aggregates on the surface of transfer films

Scratch Behavior of Multiphase Styrenic Copolymers and Effects of Environmental Conditioning

Scratch-induced surface deformation is a tribological research area that falls under the abrasive wear category. A variety of factors including high strain rate, large-scale deformation, non-linear material response, heat dissipation, and the evolution of a complex stress field, renders scratch a complex mechanical process. The dependence of polymers on testing rates, temperature, and pressure, along with the surface characteristics of the two materials in contact bring the rate, time, temperature, and pressure dependent behaviors of polymers, and the surface condition of the interacting surfaces also add to the complications of scratch analysis. In order to gain an in-depth understanding of polymer scratch behavior, this dissertation focuses on the scratch response of multiphase systems made up of a plastic matrix and a dispersed rubber phase. The introduction of a rubber phase and the effect it has on scratch behavior is explored through a number of factors including rubber size and type, environmental conditioning through heat processing, moisture exposure, and water immersion. A standardized progressive load scratch test (ASTM D7027/ISO 19252) is used to examine the mechanical response to scratch deformation in ASA and ABS systems with varying rubber particle size. Previous simulation results from finite element methods are used to assess the scratch response of the multiphase systems and comparisons are made to results based on single phase plastics and their respective scratch behavior. The key scratch damage transitions identified and studied are: (1) the onset of scratch groove formation, (2) the onset of periodic cracking, (3) the onset of material removal (plowing), and (4) the onset of scratch visibility. The onset of groove formation is generally related to the secant modulus at the point of compressive yielding. The onsets of crack formation and plowing are more complex to quantitatively evaluate, and are strongly influenced by the material tensile and/or shear strength. For ASA copolymers, enhanced scratch performance is observed in systems with rubber particles the size of 1 micron relative to 100 nm sized rubber particle systems, while ABS copolymers containing 100 nm sized rubber particles are more scratch resistant than ASA copolymer systems with similar rubber particle size and distribution. The fact that these three model systems exhibit similar mechanical properties in uniaxial tension and compression bulk testing does not explain their differences in scratch resistance based on our previous FEM modeling and experimental results for single phase systems. The local stress state generated by the rubber particles and the scratch process at the surface, along with changes in surface coefficient of friction, are used to explain these findings. In order to minimize orientation and residual stress effects from the injection molding process, heat treatments at temperatures above and below Tg were carried out on ASAs with varying rubber content, rubber size, and rubber type. Low temperature annealing (LTA) was seen to reduce rubber orientation while having no impact on bulk mechanical properties, surface characteristics, or scratch resistance. On the other hand, high temperature annealing (HTA) minimized orientation and residual stress and showed no impact on bulk mechanical properties or surface characteristics, while also leading to a significant improvement in scratch resistance for high rubber content systems

New generation of passenger vehicles: FCV or HEV

Abstract. This paper compares the performance and parameter characteristics of Fuel Cell Vehicles (FCV) and Hybrid Electric Vehicles (HEV) with a view towards an objective assessment of the relative performance of these vehicles. Firstly, the main characteristics of hybrid electric vehicles (HEVs) as low emission vehicles (LEVs), including presumed high efficiency is considered. Then, comparisons for well-to-wheels emissions for various vehicles are presented. Well-to-wheels efficiencies, emissions, and fuel economy are also compared for FCVs and HEVs. In addition, other issues like battery types for HEVs and HFCVs are explored in this paper. The potential control strategies for FCVs and HEVs will be discussed and compared. In both FCVs and HEVs, best control strategies need to rely on predicting the driver command, which presents a particularly challenging opportunity for further development. Finally, this paper gives the comparison of total costs for FCVs and HEVs

A Novel Method for Commutation Torque Ripple Reduction of Four-Switch, Three-Phase Brushless DC Motor Drive

This paper presents an original study on the generated torque ripples of phase commutation in the Four-Switch, Three-Phase Inverter (FSTPI) Brushless DC (BLDC) motor drive which is suitable for low cost applications. Analytic values of torque ripple and commutation duration are obtained for different operation conditions. Moreover, limitation on the speed range operation caused from splitting of the DC-link voltage is shown exactly. Then a novel current control technique is developed to minimize the commutation torque ripple for a wide speed range. The technique proposed here is based on a strategy that the current slopes of the rising and the decaying phases during the commutation intervals can be equalized by proper duty-ratios at commutations. Finally, the validity of the proposed analysis and developed torque ripple reduction technique are verified via simulation