26 research outputs found
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Recent Improvements To The RELAP5-3D Code
The RELAP5-3D computer program has been recently improved. Changes were made as follows: (1) heat structures are allowed to be decoupled from hydrodynamic components, (2) built-in material properties for heat structures have been made consistent with those in MATPRO and the Nuclear Systems Materials Handbook (they are now documented in the RELAP5-3D manual, (3) Schrock's flow quality correlation is now used for a downward oriented junction from a horizontal volume for the stratification entrainment/pullthrough model
Replacement of Quartz in Cementitious Composites Using PET Particles: A Statistical Analysis of the Physical and Mechanical Properties
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Multi-Applications Small Light Water Reactor - NERI Final Report
The Multi-Application Small Light Water Reactor (MASLWR) project was conducted under the auspices of the Nuclear Energy Research Initiative (NERI) of the U.S. Department of Energy (DOE). The primary project objectives were to develop the conceptual design for a safe and economic small, natural circulation light water reactor, to address the economic and safety attributes of the concept, and to demonstrate the technical feasibility by testing in an integral test facility. This report presents the results of the project. After an initial exploratory and evolutionary process, as documented in the October 2000 report, the project focused on developing a modular reactor design that consists of a self-contained assembly with a reactor vessel, steam generators, and containment. These modular units would be manufactured at a single centralized facility, transported by rail, road, and/or ship, and installed as a series of self-contained units. This approach also allows for staged construction of an NPP and ''pull and replace'' refueling and maintenance during each five-year refueling cycle
Acute deletion of the central MR/GR steroid receptor correlates with changes in LTP, auditory neural gain, and GC-A cGMP signaling
The complex mechanism by which stress can affect sensory processes such as hearing is still poorly understood. In a previous study, the mineralocorticoid (MR) and/or glucocorticoid receptor (GR) were deleted in frontal brain regions but not cochlear regions using a CaMKII alpha-based tamoxifen-inducible Cre(ERT2)/loxP approach. These mice exhibit either a diminished (MR(TMX)cKO) or disinhibited (GR(TMX)cKO) auditory nerve activity. In the present study, we observed that mice differentially were (MR(TMX)cKO) or were not (GR(TMX)cKO) able to compensate for altered auditory nerve activity in the central auditory pathway. As previous findings demonstrated a link between central auditory compensation and memory-dependent adaptation processes, we analyzed hippocampal paired-pulse facilitation (PPF) and long-term potentiation (LTP). To determine which molecular mechanisms may impact differences in synaptic plasticity, we analyzed Arc/Arg3.1, known to control AMPA receptor trafficking, as well as regulators of tissue perfusion and energy consumption (NO-GC and GC-A). We observed that the changes in PPF of MR(TMX)cKOs mirrored the changes in their auditory nerve activity, whereas changes in the LTP of MR(TMX)cKOs and GR(TMX)cKOs mirrored instead the changes in their central compensation capacity. Enhanced GR expression levels in MR(TMX)cKOs suggest that MRs typically suppress GR expression. We observed that hippocampal LTP, GC-A mRNA expression levels, and ABR wave IV/I ratio were all enhanced in animals with elevated GR (MR(TMX)cKOs) but were all lower or not mobilized in animals with impaired GR expression levels (GR(TMX)cKOs and MRGR(TMX)cKOs). This suggests that GC-A may link LTP and auditory neural gain through GR-dependent processes. In addition, enhanced NO-GC expression levels in MR, GR, and MRGR(TMX)cKOs suggest that both receptors suppress NO-GC; on the other hand, elevated Arc/Arg3.1 levels in MR(TMX)cKOs and MRGR(TMX)cKOs but not GR(TMX)cKOs suggest that MR suppresses Arc/Arg3.1 expression levels. Conclusively, MR through GR inhibition may define the threshold for hemodynamic responses for LTP and auditory neural gain associated with GC-A