365 research outputs found
Optical transparency of mesoporous metals
We examine the optical properties of metals containing a periodic arrangement
of nonoverlapping spherical mesopores, empty or filled with a dielectric
material. We show that a slab of such a porous metal transmits light over
regions of frequency determined by the dielectric constant of the cavities and
the fractional volume occupied by them, with an efficiency which is many orders
of magnitude higher than predicted by standard aperture theory. Also, the
system absorbs light efficiently over the said regions of frequency unlike the
homogeneous metal.Comment: 9 pages in total, 3 figures To be published in Solid State
Communication
Scattering of elastic waves by elastic spheres in a NaCl-type phononic crystal
Based on the formalism developed by Psarobas et al [Phys. Rev. B 62,
278(2000)], which using the multiple scattering theory to calculate properties
of simple phononic crystals, we propose a very simple method to study the
NaCl-type phononic crystal. The NaCl-type phononic crystal consists of two
kinds of non-overlapping elastic spheres with different mass densities,
coefficients and radius following the same periodicity of the
ions in the real NaCl crystal. We focus on the (001) surface, and view the
crystal as a sequence of planes of spheres, each plane of spheres has identical
2D periodicity. We obtained the complex band structure of the infinite crystal
associated with this plane, and also calculated the transmission, reflection
and absorption coefficients for an elastic wave (longitudinal or transverse)
incident, at any angle, on a slab of the crystal of finite thickness.Comment: 15 pages, 6 figure
Viscoelastic response of sonic band-gap materials
A brief report is presented on the effect of viscoelastic losses in a high
density contrast sonic band-gap material of close-packed rubber spheres in air.
The scattering properties of such a material are computed with an on-shell
multiple scattering method, properties which are compared with the lossless
case. The existence of an appreciable omnidirectional gap in the transmission
spectrum, when losses are present, is also reported.Comment: 5 pages, 4 figures, submitted to PR
Neural Circuitry of Novelty Salience Processing in Psychosis Risk: Association With Clinical Outcome
Psychosis has been proposed to develop from dysfunction in a hippocampal-striatal-midbrain circuit, leading to aberrant salience processing. Here, we used functional magnetic resonance imaging (fMRI) during novelty salience processing to investigate this model in people at clinical high risk (CHR) for psychosis according to their subsequent clinical outcomes. Seventy-six CHR participants as defined using the Comprehensive Assessment of At-Risk Mental States (CAARMS) and 31 healthy controls (HC) were studied while performing a novelty salience fMRI task that engaged an a priori hippocampal-striatal-midbrain circuit of interest. The CHR sample was then followed clinically for a mean of 59.7 months (~5 y), when clinical outcomes were assessed in terms of transition (CHR-T) or non-transition (CHR-NT) to psychosis (CAARMS criteria): during this period, 13 individuals (17%) developed a psychotic disorder (CHR-T) and 63 did not. Functional activation and effective connectivity within a hippocampal-striatal-midbrain circuit were compared between groups. In CHR individuals compared to HC, hippocampal response to novel stimuli was significantly attenuated (P = .041 family-wise error corrected). Dynamic Causal Modelling revealed that stimulus novelty modulated effective connectivity from the hippocampus to the striatum, and from the midbrain to the hippocampus, significantly more in CHR participants than in HC. Conversely, stimulus novelty modulated connectivity from the midbrain to the striatum significantly less in CHR participants than in HC, and less in CHR participants who subsequently developed psychosis than in CHR individuals who did not become psychotic. Our findings are consistent with preclinical evidence implicating hippocampal-striatal-midbrain circuit dysfunction in altered salience processing and the onset of psychosis
Acoustic properties of colloidal crystals
We present a systematic study of the frequency band structure of acoustic
waves in crystals consisting of nonoverlapping solid spheres in a fluid. We
consider colloidal crystals consisting of polystyrene spheres in water, and an
opal consisting of close-packed silica spheres in air. The opal exhibits an
omnidirectional frequency gap of considerable width; the colloidal crystals do
not. The physical origin of the bands are discussed for each case in some
detail. We present also results on the transmittance of finite slabs of the
above crystals.Comment: 7 pages, 9 figures, prb approve
Scattering of elastic waves by periodic arrays of spherical bodies
We develop a formalism for the calculation of the frequency band structure of
a phononic crystal consisting of non-overlapping elastic spheres, characterized
by Lam\'e coefficients which may be complex and frequency dependent, arranged
periodically in a host medium with different mass density and Lam\'e
coefficients. We view the crystal as a sequence of planes of spheres, parallel
to and having the two dimensional periodicity of a given crystallographic
plane, and obtain the complex band structure of the infinite crystal associated
with this plane. The method allows one to calculate, also, the transmission,
reflection, and absorption coefficients for an elastic wave (longitudinal or
transverse) incident, at any angle, on a slab of the crystal of finite
thickness. We demonstrate the efficiency of the method by applying it to a
specific example.Comment: 19 pages, 5 figures, Phys. Rev. B (in press
Symmetry characterization of eigenstates in opal-based photonic crystals
The complete symmetry characterization of eigenstates in bare opal systems is
obtained by means of group theory. This symmetry assignment has allowed us to
identify several bands that cannot couple with an incident external plane wave.
Our prediction is supported by layer-KKR calculations, which are also
performed: the coupling coefficients between bulk modes and externally excited
field tend to zero when symmetry properties mismatch.Comment: 7 pages, 5 figures, submitted to Physical Review
Effects of benzodiazepine exposure on real-world clinical outcomes in individuals at clinical high risk for psychosis
Background and Hypothesis
Animal models indicate GABAergic dysfunction in the development of psychosis, and that benzodiazepine (BDZ) exposure can prevent the emergence of psychosis-relevant phenotypes. However, whether BDZ exposure influences real-world clinical outcomes in individuals at clinical high risk for psychosis (CHR-P) is unknown.
Study Design
This observational cohort study used electronic health record data from CHR-P individuals to investigate whether BDZ exposure (including hypnotics, eg, zopiclone) reduces the risk of developing psychosis and adverse clinical outcomes. Cox proportional-hazards models were employed in both the whole-unmatched sample, and a propensity score matched (PSM) subsample.
Study Results
567 CHR-P individuals (306 male, mean[±SD] age = 22.3[±4.9] years) were included after data cleaning. The BDZ-exposed (n = 105) and BDZ-unexposed (n = 462) groups differed on several demographic and clinical characteristics, including psychotic symptom severity. In the whole-unmatched sample, BDZ exposure was associated with increased risk of transition to psychosis (HR = 1.61; 95% CI: 1.03–2.52; P = .037), psychiatric hospital admission (HR = 1.93; 95% CI: 1.13–3.29; P = .017), home visit (HR = 1.64; 95% CI: 1.18–2.28; P = .004), and Accident and Emergency department attendance (HR = 1.88; 95% CI: 1.31–2.72; P .05). In an analysis restricted to antipsychotic-naïve individuals, BDZ exposure reduced the risk of transition to psychosis numerically, although this was not statistically significant (HR = 0.59; 95% CI: 0.32–1.08; P = .089).
Conclusions
BDZ exposure in CHR-P individuals was not associated with a reduction in the risk of psychosis transition or adverse clinical outcomes. Results in the whole-unmatched sample suggest BDZ prescription may be more likely in CHR-P individuals with higher symptom severity
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