2,047 research outputs found
INVESTIGATION ON THE DISCRETIZATION OF THE REALISTIC IRREGULAR WAVE GENERATION REGION THROUGH THE WAVEMIMO METHODOLOGY
Aiming to contribute to the research related to the sea wave energy conversion, the present paper approaches an investigation of the discretization used in the region of imposition of the prescribed velocity boundary condition, which is necessary for the WaveMIMO methodology. This methodology is employed for the numeric generation of irregular waves based on realistic sea state data. These data (obtained from TOMAWAC software in the present study) are treated to obtain orbital profiles of wave propagation velocity, which are imposed as boundary conditions on the wave channel. In this study, the realistic data considered refers to a point close to the Molhes da Barra, located on the coast of the municipality of Rio Grande, Rio Grande do Sul, Brazil. The numerical simulations were performed in Fluent, a computational fluid dynamics (CFD) software based on the finite volume method (FVM). The volume of fluid (VOF) multiphase model was used on the treatment of the water-air interface. Free surface elevation data obtained when the region of imposition of the prescribed velocity boundary condition was subdivided into 8, 11 and 14 segments were compared. The results found show that the 14 segments discretization represents more precisely the free surface elevation of irregular waves
Treatment efficacy with electrochemotherapy: A multi-institutional prospective observational study on 376 patients with superficial tumors
BACKGROUND:
Cutaneous metastases represent a therapeutic challenge. An increasing body of experience suggests that electrochemotherapy (ECT) provides effective tumor control, although its evidence basis should be strengthened.
METHODS:
This prospective, multicenter, observational study enrolled patients with superficial metastases, who underwent ECT at 10 centers between 2008 and 2013. Outcomes included adherence to European Standard Operating Procedures of ECT (ESOPE), tumor response, local progression-free survival (LPFS), toxicity and patient-reported outcomes (PROs, EORTC QLQ-C30 plus an 8-item questionnaire).
RESULTS:
We enrolled 376 eligible patients. Tumor histotype distribution was as follows: melanoma, 56%; squamous cell carcinoma, 11%; Kaposi sarcoma, 11%; breast carcinoma, 8%; basal cell carcinoma, 6%; soft tissue sarcomas, 3%; others, 5%. We registered 1304 target tumors (median size 1 cm). Treatment adhered to ESOPE in 88% of patients as to the route of drug administration, and in 70% as to electrode application. The procedure was mainly performed under sedation (64.6%) and by using intravenous chemotherapy (93.4%). Tumor response rate at 60 days was 88% (complete, 50%). Small tumor size predicted complete response achievement (OR 2.24, p = 0.003), higher LPFS (HR 0.68, p = 0.004) and improved PROs (Global Health Status, p < 0.001; wound bleeding, p < 0.001; healing, p = 0.002; and aesthetics, p < 0.001). Skin toxicity (grade 653, 7.8%) was lower in patients with tumors <2 cm (p 640.001). One-year LPFS was 73.7% (95%CI 68.4-78.3).
CONCLUSIONS:
ECT represents a valuable skin-directed therapy across a range of malignancies. The most frequently applied treatment modality is intravenous chemotherapy under sedation. Small tumor size predicts durable tumor control, fewer side-effects and better PROs
Computer Simulation of Final-Stage Sintering: II, Influence of Initial Pore Size
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/65612/1/j.1151-2916.1990.tb06687.x.pd
Constraints on the χ_(c1) versus χ_(c2) polarizations in proton-proton collisions at √s = 8 TeV
The polarizations of promptly produced χ_(c1) and χ_(c2) mesons are studied using data collected by the CMS experiment at the LHC, in proton-proton collisions at √s=8 TeV. The χ_c states are reconstructed via their radiative decays χ_c → J/ψγ, with the photons being measured through conversions to e⁺e⁻, which allows the two states to be well resolved. The polarizations are measured in the helicity frame, through the analysis of the χ_(c2) to χ_(c1) yield ratio as a function of the polar or azimuthal angle of the positive muon emitted in the J/ψ → μ⁺μ⁻ decay, in three bins of J/ψ transverse momentum. While no differences are seen between the two states in terms of azimuthal decay angle distributions, they are observed to have significantly different polar anisotropies. The measurement favors a scenario where at least one of the two states is strongly polarized along the helicity quantization axis, in agreement with nonrelativistic quantum chromodynamics predictions. This is the first measurement of significantly polarized quarkonia produced at high transverse momentum
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