3,246 research outputs found
Viscoelastic evaluation of biological soft tissue in crush process at subsonic level for anti-bird strike technology of airplane
Miniaturization and lightening of airplane are advanced to improve its economic efficiency, and the safety technology of airplane design becomes difficult while the accident of bird-strike is increasing year by year. Then a system of shock impact test by using airsoft rifle is developed to evaluate the design technology of anti-bird strike structure of airplane. The viscoelastic characteristics of specimen is evaluated by analyzing stress response using the modified Hertz contact theory and the wave equation at the moment when simple ball bullet is shot to specimen by the airsoft rifle. In the results of experiment, the obvious relationship is observed subjectively between quasi-static and impact responses of specimen. The evaluated viscoelastic relationship is applied to simulate the impact test by using LSDYNA with fundamental viscoelastic constitutive equation and the material parameters derived from the impact test, and the well similar behavior has been simulated by the constitutive equation. By using the developed technology here, the phantom imitating real bird will be developed as standard specimen for an anti-bird strike test in future
Delayed particles in EAS at Akeno
Using two 2.25 square meter fast scintillation detectors, delayed particles in cosmic ray showers (CRS) have been observed at Akeno Observatory. These are set under 1 m concrete and 2.5 cm lead plates respectively. About 2500 CRS are analyzed. The lateral distribution of delayed particles for the CRS size 10 to the 7th power is flatter than that for to the 7th power. The lateral density of delayed particles is almost constant for the size range 2.2 X 10 to the 5th power approx. 10 to the 7th power and increases rapidly above 10 to the 7th power. These facts may suggest change of nuclear interaction at 10 to the 7th power and substantially the existence of heavy particles with long life
Relocation of active acetylcholinesterase to liposome-gel conjugate
ArticleJOURNAL OF COLLOID AND INTERFACE SCIENCE. 307(1): 296-299 (2007)journal articl
Immobilization of liposomes on hydrophobically modified polymer gel particles in batch mode interaction
ArticleCOLLOIDS AND SURFACES B-BIOINTERFACES. 55(2): 235-240 (2007)journal articl
A Minimum-Labeling Approach for Reconstructing Protein Networks across Multiple Conditions
The sheer amounts of biological data that are generated in recent years have
driven the development of network analysis tools to facilitate the
interpretation and representation of these data. A fundamental challenge in
this domain is the reconstruction of a protein-protein subnetwork that
underlies a process of interest from a genome-wide screen of associated genes.
Despite intense work in this area, current algorithmic approaches are largely
limited to analyzing a single screen and are, thus, unable to account for
information on condition-specific genes, or reveal the dynamics (over time or
condition) of the process in question. Here we propose a novel formulation for
network reconstruction from multiple-condition data and devise an efficient
integer program solution for it. We apply our algorithm to analyze the response
to influenza infection in humans over time as well as to analyze a pair of ER
export related screens in humans. By comparing to an extant, single-condition
tool we demonstrate the power of our new approach in integrating data from
multiple conditions in a compact and coherent manner, capturing the dynamics of
the underlying processes.Comment: Peer-reviewed and presented as part of the 13th Workshop on
Algorithms in Bioinformatics (WABI2013
Amplitude-Phase Coupling in a Spin-Torque Nano-Oscillator
The spin-torque nano-oscillator in the presence of thermal fluctuation is
described by the normal form of the Hopf bifurcation with an additive white
noise. By the application of the reduction method, the amplitude-phase coupling
factor, which has a significant effect on the power spectrum of the spin-torque
nano-oscillator, is calculated from the Landau-Lifshitz-Gilbert-Slonczewski
equation with the nonlinear Gilbert damping. The amplitude-phase coupling
factor exhibits a large variation depending on in-plane anisotropy under the
practical external fields.Comment: 4 pages, 4 figures, submitted to Journal of Applied Physics via MMM
200
Autophagosome formation is initiated at phosphatidylinositol synthaseâenriched ER subdomains
The autophagosome, a doubleâmembrane structure mediating degradation of cytoplasmic materials by macroautophagy, is formed in close proximity to the endoplasmic reticulum (ER). However, how the ER membrane is involved in autophagy initiation and to which membrane structures the autophagyâinitiation complex is localized have not been fully characterized. Here, we were able to biochemically analyze autophagic intermediate membranes and show that the autophagyâinitiation complex containing ULK and FIP200 first associates with the ER membrane. To further characterize the ER subdomain, we screened phospholipid biosynthetic enzymes and found that the autophagyâinitiation complex localizes to phosphatidylinositol synthase (PIS)âenriched ER subdomains. Then, the initiation complex translocates to the ATG9Aâpositive autophagosome precursors in a PI3Pâdependent manner. Depletion of phosphatidylinositol (PI) by targeting bacterial PIâspecific phospholipase C to the PIS domain impairs recruitment of downstream autophagy factors and autophagosome formation. These findings suggest that the autophagyâinitiation complex, the PISâenriched ER subdomain, and ATG9A vesicles together initiate autophagosome formation
Majorana edge modes of superfluid 3He A-phase in a slab
Motivated by a recent experiment on the superfluid 3He A-phase with a chiral
p-wave pairing confined in a thin slab, we propose designing a concrete
experimental setup for observing the Majorana edge modes that appear around the
circumference edge region. We solve the quasi-classical Eilenberger equation,
which is quantitatively reliable, to evaluate several observables. To derive
the property inherent to the Majorana edge state, the full quantum mechanical
Bogoliubov-de Gennes equation is solved in this setting. On the basis of the
results obtained, we perform decisive experiments to check the Majorana nature.Comment: 5 pages, 5 figure
Evolution and insights into the structure and function of the DedA superfamily containing TMEM41B and VMP1
TMEM41B and VMP1 are endoplasmic reticulum (ER)-localizing multi-spanning membrane proteins required for ER-related cellular processes such as autophagosome formation, lipid droplet homeostasis, and lipoprotein secretion in eukaryotes. Both proteins have a VTT domain, which is similar to the DedA domain found in bacterial DedA family proteins. However, the molecular function and structure of the DedA and VTT domains (collectively referred to as DedA domains) and the evolutionary relationships among the DedA domain-containing proteins are largely unknown. Here, we conduct remote homology search and identify a new clade consisting mainly of bacterial PF06695 proteins of unknown function. Phylogenetic analysis reveals that the TMEM41, VMP1, DedA, and PF06695 families form a superfamily with a common origin, which we term the DedA superfamily. Coevolution-based structural prediction suggests that the DedA domain contains two reentrant loops facing each other in the membrane. This topology is biochemically verified by the substituted cysteine accessibility method. The predicted structure is topologically similar to that of the substrate-binding region of Na+-coupled glutamate transporter solute carrier 1. A potential ion-coupled transport function of the DedA superfamily proteins is discussed
Asymmetric Fermi superfluid with different atomic species in a harmonic trap
We study the dilute fermion gas with pairing between two species and unequal
concentrations in a harmonic trap using the mean field theory and the local
density approximation. We found that the system can exhibit a superfluid shell
structure sandwiched by the normal fermions. This superfluid shell structure
occurs if the mass ratio is larger then certain critical value which increases
from the weak-coupling BCS region to the strong-coupling BEC side. In the
strong coupling BEC regime, the radii of superfluid phase are less sensitive to
the mass ratios and are similar to the case of pairing with equal masses.
However, the lighter leftover fermions are easier to mix with the superfluid
core than the heavier ones. A partially polarized superfluid can be found if
the majority fermions are lighter, whereas phase separation is still found if
they are heavier.Comment: 12 pages, 7 figure
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