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Diastereoselective α‑Alkylation of Metallo Enamines Generated from N–C Axially Chiral Mebroqualone Derivatives
The reactions of
various alkyl halides with the metallo enamines
generated from racemic and optically pure N–C axially chiral
mebroqualone derivatives were found to proceed with a synthetically
attractive stereochemical outcome (up to 99% yield and up to dr =
26:1) allowing preparation of a structurally new type of pharmaceutically
interesting compounds possessing elements of axial and central chirality