A Case of Cervical Epidural Abscess -Diagnosis using MRI and non -surgical treatment -

A 65-year-old man with cervical epidural abscess presented with high fever and severe neck pain. On admission, he had difficulty in walking, and the next day paralysis and hyposthesia below the level of C6 developed. Magnetic resonance imaging (MRI) revealed an anterior epidural abscess at C5-7, verteveral bodies levels. All of three blood cultures were positive for Staphylococcus aureus. He was treated with ceftazidame and ampicillin, supplemented with rifampicin and isoniazid for four weeks. The follow-up MRI demonstrated resolution of the abscess and cord compression. After three months, the patient was able to walk with a stick

The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force

「コロナ制圧タスクフォース」COVID-19患者由来の血液細胞における遺伝子発現の網羅的解析 --重症度に応じた遺伝子発現の変化には、ヒトゲノム配列の個人差が影響する--. 京都大学プレスリリース. 2022-08-23.Coronavirus disease 2019 (COVID-19) is a recently-emerged infectious disease that has caused millions of deaths, where comprehensive understanding of disease mechanisms is still unestablished. In particular, studies of gene expression dynamics and regulation landscape in COVID-19 infected individuals are limited. Here, we report on a thorough analysis of whole blood RNA-seq data from 465 genotyped samples from the Japan COVID-19 Task Force, including 359 severe and 106 non-severe COVID-19 cases. We discover 1169 putative causal expression quantitative trait loci (eQTLs) including 34 possible colocalizations with biobank fine-mapping results of hematopoietic traits in a Japanese population, 1549 putative causal splice QTLs (sQTLs; e.g. two independent sQTLs at TOR1AIP1), as well as biologically interpretable trans-eQTL examples (e.g., REST and STING1), all fine-mapped at single variant resolution. We perform differential gene expression analysis to elucidate 198 genes with increased expression in severe COVID-19 cases and enriched for innate immune-related functions. Finally, we evaluate the limited but non-zero effect of COVID-19 phenotype on eQTL discovery, and highlight the presence of COVID-19 severity-interaction eQTLs (ieQTLs; e.g., CLEC4C and MYBL2). Our study provides a comprehensive catalog of whole blood regulatory variants in Japanese, as well as a reference for transcriptional landscapes in response to COVID-19 infection

DOCK2 is involved in the host genetics and biology of severe COVID-19

「コロナ制圧タスクフォース」COVID-19疾患感受性遺伝子DOCK2の重症化機序を解明 --アジア最大のバイオレポジトリーでCOVID-19の治療標的を発見--. 京都大学プレスリリース. 2022-08-10.Identifying the host genetic factors underlying severe COVID-19 is an emerging challenge. Here we conducted a genome-wide association study (GWAS) involving 2, 393 cases of COVID-19 in a cohort of Japanese individuals collected during the initial waves of the pandemic, with 3, 289 unaffected controls. We identified a variant on chromosome 5 at 5q35 (rs60200309-A), close to the dedicator of cytokinesis 2 gene (DOCK2), which was associated with severe COVID-19 in patients less than 65 years of age. This risk allele was prevalent in East Asian individuals but rare in Europeans, highlighting the value of genome-wide association studies in non-European populations. RNA-sequencing analysis of 473 bulk peripheral blood samples identified decreased expression of DOCK2 associated with the risk allele in these younger patients. DOCK2 expression was suppressed in patients with severe cases of COVID-19. Single-cell RNA-sequencing analysis (n = 61 individuals) identified cell-type-specific downregulation of DOCK2 and a COVID-19-specific decreasing effect of the risk allele on DOCK2 expression in non-classical monocytes. Immunohistochemistry of lung specimens from patients with severe COVID-19 pneumonia showed suppressed DOCK2 expression. Moreover, inhibition of DOCK2 function with CPYPP increased the severity of pneumonia in a Syrian hamster model of SARS-CoV-2 infection, characterized by weight loss, lung oedema, enhanced viral loads, impaired macrophage recruitment and dysregulated type I interferon responses. We conclude that DOCK2 has an important role in the host immune response to SARS-CoV-2 infection and the development of severe COVID-19, and could be further explored as a potential biomarker and/or therapeutic target

Diffuse Alveolar Hemorrhage Caused by Warfarin after Rifampicin Discontinuation

An 83-year-old man under warfarin therapy presented for assessment of prolonged prothrombin time and cough. High-resolution computed tomography findings of the chest showed diffuse alveolar hemorrhage. His international normalized ratio (INR) was 11.89. He had been treated with rifampicin for a persistent infection, but this had been discontinued about two months before admission. Rifampicin suppresses the anticoagulant activity of warfarin, which can lead to a need for increased doses of warfarin to achieve and maintain a therapeutic INR. More frequent INR monitoring is needed even after discontinuing rifampicin

Business Analysis of the Kyushu University Forest (Report No. 3) : Report of Charcoal Business Control by Means of the Cost Control of Kasuya University Forest in 1957 Fiscal Year

I 緒言　II 経営案と製炭事業 §1 経営組織論より見た組成と管理の関係　§2 経営管理職能と標準原価計算　§3 経営案における全経営と部分経営としての製炭事業経営　 A 「製炭事業」の実質　B 天然性広葉樹林早期整理計画　C 製炭事業の収支予算　III 標準原価の決定　§1 材料費標準の決定　§2 労務費標準の決定　§3 製造間接費標準の決定　§4 製品標準原価表の作成　IV　製炭事業の原価管理　§1 直接材料費　A 標準直接材料歩留率の計算　B 材料標準消費量　C 材料標準単価　D 直接材料費差異　E 材料物量差異の分析　F 材料差異の原因分析　§2 労務費　A 作業別標準功程及び標準労務費　B 労務費差異分析　C 差異原因の考察　§3 プロット材積の算定　§4 蓄積の推定　§5 樹種別材積の推定　§6 径級別材積の推定　§3 製造間接費　A 標準製造間接費の計算　B 製造間接費差額の分析　C 製造間接費差異の原因分析　V　結論　参考文献　ResumeIn this report, the charcoal business control was intended by means of the cost control, which means the analysis of variations between the current standard costs and the actual costs, with the causes inquired into, and the following findings were made. Consumption of the direct materials was fairly good, but there were some problems in the indirect production costs, Especially, it must be reconsidered how well the fixed equipment is utilized. Contrarily, the result of analysis of the difference of labour costs shows that the limit of rationalization in labour prices, especially in wages, has been reached

Analysis of Mechanism of Bambo-Circulation : Citing Bamboo and Bamboo Products Industry in Oita Prefecture as An Instance

緒言　I 大分県の竹材資源の現況　1） 九州地方の竹材資源の位置　2） 竹材資源の数量的特色　3） 竹材資源の質的構成　4） 郡市別竹材資源の類型　II 大分県の竹製品生産の現況　1) 竹製品業の発達　2) 竹材業者数と経営規模　3) 竹製品の生産機構ー輸出向釣竿を例としてー　4) 原竹の生産技術　5) 工場における作業工程と技術　6) 労働力配置　7) D出先工場における原竹の搬入及び搬出高と原竹貯蔵高の季節的変化　8) D出先工場における釣竿生産の労働生産性　III 大分県の竹材需給の現況　1) 竹材の生産状況　2) 竹材及び竹製品の需要　3) 竹製品の輸出　IV 流通機構　1) 流通機構の骨格　2) 原竹の流通機構　3) 半製品の流通機構　4) 製品の流通機構 V 価格構成　1) 山工場と出先工場の取引段階　2) 中買人と山工場の取引段階　3) 山主と仲買人の取引段階　4) 出先工場と貿易商の取引段階　5) 貿易商とバイヤーの取引段階　VI 結論　ResumeBamboo and bamboo products industries in Oita Prefecture were analyzed and studied from the point of view of circulation. The analysis shows that there are some problems in the bamboo and bamboo products industries, which suggest the way to reform them as follows; Madake is the main bamboo resource in Oita Prefecture. Although there are considerable forests to be improved, the forests in the area adjacent to the market have been exhausted. Lately, the demand for Hoteichiku has increased in such a rapid pace that more Hoteichiku should be accumulated in Oita Prefecture. Special caution should be exercised in the work of bamboo forests adjacent to the market. For instance, in the case of fishing pole manufacturing industry, it is evident that the organization of the production mechanism is established in a systematic way. The other charactors of the bamboo products industries are seasonal fluctuations in productive operation, material demand, operating labor forces, etc. The storage facilities for bamboos and products should be improved. The annual supply of bamboos is about one million Soku. The growth of demand will exceed the supply in future. A tendency of exhausting of bamboo resources is intensified by brokers operating in the circulation Felling and transportation should be done by co-operative system composed of the forest owners. The price at forest is only 0.2-0.5yen per bamboo and that delivered to Kobe is about 7-15yen per a 14-feet pole. Co-operative system will bring more reforesting capital to the forest owners