Dose the Spread of COVID-19 Affect the Physical Health Management of University Staffs ?: Data from Annual Health Checkups

新型コロナウイルス感染拡大により生活様式が変化したが，新型コロナウイルス感染拡大が大学職員の健康管理に及ぼした影響は明らかでない。本研究では40歳以上の大学職員1608名を対象に，新型コロナウイルス感染拡大前後の職員健康診断データを比較検討した。年齢を調整すると，感染拡大前と比較して，感染拡大後ではALT（β= 0.04, P = 0.02），HDL コレステロール（β= -0.07, P = 0.0002），LDL コレステロール（β= 0.04, P = 0.02）が悪化した一方で，HbA1c（β= -0.04, P = 0.02）は改善した。BMI，腹囲，AST，γ-GT，血糖値，中性脂肪，収縮期血圧，拡張期血圧，尿酸については感染拡大前後で変化を認めなかった。大学職員の健康管理において，感染拡大による職員個人のライフスタイル変化を考慮した生活指導が重要と考えられる。Although the spread of COVID-19 brought radical change to our lifestyle, its impact on health management of university staff is unknown. We enrolled 1608 Hiroshima University staff aged 40 years or more and compared their health checkup data before and after the spread of COVID-19. After adjustment for age, values of alanine aminotransferase (β= 0.04, P = 0.02), high-density lipoprotein cholesterol (β= -0.07, P = 0.0002), and low-density lipoprotein cholesterol (β= 0.04, P = 0.02) were worsened due to the spread of COVID-19. However, hemoglobin A1c (β= -0.04, P = 0.02) was improved, and values of body mass index, waist circumference, aspartate transaminase, γ-glutamyl transpeptidase, blood glucose, triglyceride, systolic and diastolic blood pressure, and uric acid were unchanged by the spread of COVID-19. For better physical health management of the university staff, individual lifestyle changes due to the spread of COVID-19 need to be considered

Photoinduced hydrogen release from hydrogen boride sheets

Hydrogen boride nanosheets (HB sheets) are facilely synthesized via ion-exchange treatment on magnesium diboride (MgB2) in an acetonitrile solution. Optical absorption and fluorescence spectra of HB sheets indicate that their bandgap energy is 2.8 eV. According to first-principles calculations, optical absorption seen at 2.8 eV is assigned to the electron transition between the sigma-bonding states of B and H orbitals. In addition, density functional theory (DFT) calculations suggest the other allowed transition from the s-bonding state of B and H orbitals to the antibonding state with the gap of 3.8 eV. Significant gaseous H-2 release is found to occur only under photoirradiation, which causes the electron transition from the s-bonding state to the antibonding state even under mild ambient conditions. The amount of H-2 released from the irradiated HB sheets is estimated to be 8 wt%, indicating that the sheets have a high H-2-storage capacity compared with previously reported metal H-2-storage materials

Giant gastrointestinal stromal tumor, associated with esophageal hiatus hernia

An 85-year-old woman was admitted to our hospital because of vomiting. An upper gastrointestinal series what showed a large esophageal hiatus hernia, suggesting an association with extrinsic pressure in the middle portion of the stomach. An upper gastrointestinal endoscopic examination showed severe esophagitis and a prominent narrowing in the middle portion of the stomach, however, it showed normal gastric mucosa findings. CT and MRI revealed a large tumor extending from the region of the lower chest to the upper abdomen. From these findings, the tumor was diagnosed as gastrointestinal stromal tumor(GIST), which arose from the gastric wall and complicated with an esophageal hiatus hernia. We performed a laparotomy, however, the tumor showed severe invasion to the circumferential organs. Therefore, we abandoned the excision of the tumor. Histologically, the tumor was composed of spindle shaped cells with marked nuclear atypia and prominent mitosis. The tumor cells were strongly positive for CD34 and c-kit by immunohistochemical examination. From these findings, the tumor was definitely diagnosed as a malignant GIST. As palliative treatment, we implanted a self-expandable metallic stent in the narrow segment of the stomach. The patient could eat solid food and was discharged. In the treatment of esophageal hiatus hernia, the rare association of GIST should be considered

Transcriptional activity of the 5′-flanking region of the thyroid transcription factor-1 gene in human thyroid cell lines

Thyroid transcription factor-1 (TTF-1, NKX2-1) is a homeodomain-containing transcriptional factor that binds to and activates the promoters of thyroid and lung-specific genes, such as thyroglobulin, thyroid peroxidase, and thyroid stimulating hormone receptor. TTF-1 is known to play a key role in the development of the thyroid. However, the precise mechanism of TTF-1 gene transcription in human thyroid cells has not been studied. The expression of transcriptional activity in various lengths of the 5′-flanking region of the human TTF -1 gene was studied in TTF-1 positive and negative human thyroid cell lines. Increased transcriptional activity was observed in thyroid cell lines containing plasmids that coded for a sequence proximal to the transcription start site of exon 1 of the TTF-1 gene. However, we did not observe any difference in promoter activity in the region up to −2.6 kb from the proximal transcription start site of the TTF-1 gene between TTF-1 positive and negative cells. These results suggest that the proximal 5′-flanking region of the human TTF -1 gene does not contain sufficient cis-active regulatory information to direct gene expression in thyroid cells, and that other cis- or trans-acting factors participate in the thyroid specific gene expression of TTF-1

Prevalence and associated factors of chronic constipation among Japanese university students

BackgroundChronic constipation (CC) is one of the most frequently reported gastrointestinal disorders in the general population and a prominent problem among university students. The study aimed to evaluate the prevalence and the associated factors of CC among Japanese university students.MethodsThis cross-sectional study was conducted among university students at Hiroshima University, Japan. Students answered the web questionnaire when making a web reservation for the health checkup (April 1 to May 31, 2023). The web questionnaire consisted of four sections, including baseline characteristics, lifestyle factors, family history of CC, and three scales to assess depression and eating disorders: the Beck Depression Inventory (BDI), Eating Attitudes Test (EAT)-26 and Bulimic Investigatory Test (BITE). CC was diagnosed using Rome IV criteria. The multivariate logistic regression model was used to determine CC-related factors.ResultsOut of 10,500 individuals who participated in the annual health checkup, 7,496 participants answered the web questionnaire, of whom 5,386 answered all the survey questions. The mean age of the students was 21.1 ± 4.1 years. The male-to-female ratio was 1:1.17. The prevalence of CC was 13.7%. Factors significantly associated with CC in the multivariate model were first-degree family members with CC [Odd ratio (OR): 2.77, 95% confidence interval (CI): 2.31–3.31], severe depression according to BDI scale (OR: 2.59, 95% CI: 1.96–3.43), female sex (OR: 2.00, 95% CI: 1.69–2.36), and short sleep duration of 6 hours or less per day (OR: 1.28, 95% CI: 1.09–1.50). Lack of physical exercise tended to be associated with CC (OR: 1.19, 95% CI: 1.00–1.40).ConclusionsCC is prevalent among Japanese university students. Significant risk factors for CC included the first-degree family history of CC, severe depression, female sex, and short sleep duration. Lack of physical exercise tended to be associated with CC. This may contribute to implementing suitable education health programs, health care professionals, and public health policies to identify individuals at risk for CC to prevent and treat CC effectively

New Stand-Alone and Advanced Earthquake Early Warning Systems Designed to Protect Railways

A new earthquake detection and warning system that uses single station records was designed. The system determines the location and magnitude of an earthquake and issues an alarm immediately after arrival of the P wave (primary wave or longitudinal waves). In the conventional system now in use with Shinkansen (“bullet”) trains, magnitude is first determined and then distance is evaluated. In the new system, the distance to an epicenter is initially determined, followed by the magnitude. Findings have shown that the initial rate of increase in P-wave amplitude is inversely proportional to the epicentral distance. This relation can be used to estimate the distance in a time interval as short as 2 or 3 s after arrival of the P wave. Then an estimate of magnitude can be made from the maximum amplitude observed within any given time interval after P-wave arrival. This method is preferable to the conventional one because larger earthquakes involve longer rupture times, and it is questionable whether magnitude can be estimated correctly in such a short time after arrival of the P wave. Another new system uses earthquake early warning (EEW) information. The Japan Meteorological Agency (JMA), which has a seismic network that covers all of Japan, is responsible for routine earthquake and tsunami observations. The new system receives EEW information from JMA together with the information obtained by railway facilities, executes a risk assessment for the areas concerned, and issues an earthquake warning if necessary. The system could effectively cover most of Japan, and the reliability of the information provided may be far better than that produced by the stand-alone system. Also, the system could significantly improve outcomes to early adjustments of train operations in the event of an earthquake

Attitudes and Behavior toward COVID-19 Vaccination in Japanese University Students: A Cross-Sectional Study

Background: It is said that safe and effective vaccination is an important tool to end the COVID-19 pandemic. However, recent studies have reported hesitation, especially in young adults. Promoting the vaccination of university students, who represent the young adults, will lead to infection prevention measures. The purpose of this study was to clarify to compare the vaccination rates, attitudes toward vaccines, and post-vaccination behavior of students and faculty members in order to understand the actual situation of young population. Methods: We conducted large-scale vaccination of Hiroshima University from 21 June to 18 September 2021. This cross-sectional survey was conducted via e-mail from 27 September to 3 October 2021. Results: The number of second inoculations was 10,833 /14,154 students (76.5%), and 2240/2583 staff members (86.7%). Regarding the impressions after vaccination, the most common answer was “I was able to prevent worsening of the disease even if I was infected”. Many students answered that their range of activities had expanded after vaccination. However, many students (n = 1799, 87.8%) answered as having “no change after vaccination” regarding infection prevention. Conclusion: The high vaccination rate in this survey was thought to be due to the increased sense of security and confidence in the vaccine. The fact that young adults who perform a wide range of activities are careful about infection prevention may be one of the factors that prevents the explosive spread of infection in Japan