5 research outputs found
Activation of HIV-1 expression in latently infected CD4+ T cells by the small molecule PKC412
Variant in the sequence of the LINGO1 gene confers risk of essential tremor
To access publisher full text version of this article. Please click on the hyperlink in Additional Links fieldWe identified a marker in LINGO1 showing genome-wide significant association (P = 1.2 x 10(-9), odds ratio = 1.55) with essential tremor. LINGO1 has potent, negative regulatory influences on neuronal survival and is also important in regulating both central-nervous-system axon regeneration and oligodendrocyte maturation. Increased axon integrity observed in Lingo1 mouse [corrected] knockout models highlights the potential role of LINGO1 in the pathophysiology of ET [corrected