Discovery and Assessment of New Target Sites for Anti-HIV Therapies

Human immunodeficiency virus (HIV) infects cells by endocytosis and takes over parts of the cell’s reaction pathways in order to reproduce itself and spread the infection. One such pathway taken over by HIV becomes the inflammatory pathway which uses Nuclear Factor κB (NF-κB) as the principal transcription factor. Therefore, knocking out the NF-κB pathway would prevent HIV from reproducing itself. In this report, our goal is to produce a simple model for this pathway with which we can identify potential targets for anti-HIV therapies and test out various hypotheses. We present a very simple model with four coupled first-order ODEs and see what happens if we treat IκK concentration as a parameter that can be controlled (by some unspecified means). In Section 3, we augment this model to account for activation and deactivation of IκK, which is controlled (again, by some unspecified means) by TNF

Mediators of mechanotransduction between bone cells

Mechanical forces are known to regulate the function of tissues in the body, including bone. Bone adapts to its mechanical environment by altering its shape and increasing its size in response to increases in mechanical load associated with exercise, and by decreasing its size in response to decreases in mechanical load associated with microgravity or prolonged bed rest. Changes in bone size and shape are produced by a cooperative action of two main types of the bone cells - osteoclasts that destroy bone and osteoblasts that build bone. These cell types come from different developmental origins, and vary greatly in their characteristics, such as size, shape, and expression of receptor subtypes, which potentially may affect their responses to mechanical stimuli. The objective of this study is to compare the responses of osteoclasts and osteoblasts to mechanical stimulation. This study has allowed us to conclude the following: 1. A mediator is released from a single source cell. 2. The response to the mediator changes with distance. 3. The value of the apparent diffusion coeficient increases with distance. 4. A plausible proposed mechanism is that ATP is released and degrades to ADP. 5. Future experiments are required to confim that ATP is the mediator as suggested

CoFeB Thickness Dependence of Thermal Stability Factor in CoFeB/MgO Perpendicular Magnetic Tunnel Junctions

Thermal stability factor (delta) of recording layer was studied in perpendicular anisotropy CoFeB/MgO magnetic tunnel junctions (p-MTJs) with various CoFeB recording layer thicknesses and junction sizes. In all series of p-MTJs with different thicknesses, delta is virtually independent of the junction sizes of 48-81 nm in diameter. The values of delta increase linearly with increasing the recording layer thickness. The slope of the linear fit is explained well by a model based on nucleation type magnetization reversal.Comment: 12 pages, 5 figure

Measurement of Resonant Frequency and Quality Factor of Microwave Resonators: Comparison of Methods

Precise microwave measurements of sample conductivity, dielectric, and magnetic properties are routinely performed with cavity perturbation measurements. These methods require the accurate determination of quality factor and resonant frequency of microwave resonators. Seven different methods to determine the resonant frequency and quality factor from complex transmission coefficient data are discussed and compared to find which is most accurate and precise when tested using identical data. We find that the nonlinear least-squares fit to the phase vs. frequency is the most accurate and precise when the signal-to-noise ratio is greater than 65. For noisier data, the nonlinear least squares fit to a Lorentzian curve is more accurate and precise. The results are general and can be applied to the analysis of many kinds of resonant phenomena.Comment: 29 pages, 11 figure

Tests of star formation metrics in the low metallicity galaxy NGC 5253 using ALMA observations of H30α\alpha line emission

We use Atacama Large Millimeter/submillimeter Array (ALMA) observations of H30$\alpha$ (231.90 GHz) emission from the low metallicity dwarf galaxy NGC 5253 to measure the star formation rate (SFR) within the galaxy and to test the reliability of SFRs derived from other commonly-used metrics. The H30$\alpha$ emission, which originates mainly from the central starburst, yields a photoionizing photon production rate of (1.9$\pm$0.3)$\times$10$^{52}$ s$^{-1}$ and an SFR of 0.087$\pm$0.013 M$_\odot$ yr$^{-1}$ based on conversions that account for the low metallicity of the galaxy and for stellar rotation. Among the other star formation metrics we examined, the SFR calculated from the total infrared flux was statistically equivalent to the values from the H30$\alpha$ data. The SFR based on previously-published versions of the H$\alpha$ flux that were extinction corrected using Pa$\alpha$ and Pa$\beta$ lines were lower than but also statistically similar to the H30$\alpha$ value. The mid-infrared (22 $\mu$m) flux density and the composite star formation tracer based on H$\alpha$ and mid-infrared emission give SFRs that were significantly higher because the dust emission appears unusually hot compared to typical spiral galaxies. Conversely, the 70 and 160 $\mu$m flux densities yielded SFR lower than the H30$\alpha$ value, although the SFRs from the 70 $\mu$m and H30$\alpha$ data were within 1-2$\sigma$ of each other. While further analysis on a broader range of galaxies are needed, these results are instructive of the best and worst methods to use when measuring SFR in low metallicity dwarf galaxies like NGC 5253.Comment: 14 pages, 5 figures, accepted for publication in MNRA

U-Note: Capture the Class and Access it Everywhere

We present U-Note, an augmented teaching and learning system leveraging the advantages of paper while letting teachers and pupils benefit from the richness that digital media can bring to a lecture. U-Note provides automatic linking between the notes of the pupils' notebooks and various events that occurred during the class (such as opening digital documents, changing slides, writing text on an interactive whiteboard...). Pupils can thus explore their notes in conjunction with the digital documents that were presented by the teacher during the lesson. Additionally, they can also listen to what the teacher was saying when a given note was written. Finally, they can add their own comments and documents to their notebooks to extend their lecture notes. We interviewed teachers and deployed questionnaires to identify both teachers and pupils' habits: most of the teachers use (or would like to use) digital documents in their lectures but have problems in sharing these resources with their pupils. The results of this study also show that paper remains the primary medium used for knowledge keeping, sharing and editing by the pupils. Based on these observations, we designed U-Note, which is built on three modules. U-Teach captures the context of the class: audio recordings, the whiteboard contents, together with the web pages, videos and slideshows displayed during the lesson. U-Study binds pupils' paper notes (taken with an Anoto digital pen) with the data coming from U-Teach and lets pupils access the class materials at home, through their notebooks. U-Move lets pupils browse lecture materials on their smartphone when they are not in front of a computer

The comfortable roller coaster -- on the shape of tracks with constant normal force

A particle that moves along a smooth track in a vertical plane is influenced by two forces: gravity and normal force. The force experienced by roller coaster riders is the normal force, so a natural question to ask is: what shape of the track gives a normal force of constant magnitude? Here we solve this problem. It turns out that the solution is related to the Kepler problem; the trajectories in velocity space are conic sections.Comment: 10 pages, 4 figure