Associations between serum magnesium levels and Proton Pump inhibitor use as determined by regression analyses.

<p>Reference category is the patients on no acid suppressive medications. β-coefficients ± s.e’s and <i>P</i> values are provide for each variable. Model I includes age, dialysis vintage and sex. Model II includes all variables in Model I and the addition of Diabetes mellitus, Kt/V, systolic blood pressure, albumin, potassium, C-reactive protein, sodium, blood urea nitrogen, parathyroid hormone, phosphorus, calcium, hemoglobin, furosemide, antiplatelet drug, vitamin K antagonist, angiotensin converting enzyme inhibitor or angiotensin II receptor blocker, phosphate binder, vitamin D receptor antagonist, atrial fibrillation, gastric hemorrhage, cerebral infarction, and ischemic heart disease. Conversion factors for units: serum magnesium in mg/dL to mol/L, *0.4114.</p><p>Associations between serum magnesium levels and Proton Pump inhibitor use as determined by regression analyses.</p

Logistic analysis between Proton Pump inhibitor use and hypomagnesemia.

<p>Hypomagnesemia is defined as ≤ 2.0 mg/dL (0.82mmol/L). Adjusted models includes age, dialysis vintage, sex, Diabetes mellitus, Kt/V, systolic blood pressure, albumin, potassium, C-reactive protein, sodium, blood urea nitrogen, parathyroid hormone, phosphorus, calcium, hemoglobin, furosemide, antiplatelet drug, vitamin K antagonist, angiotensin converting enzyme inhibitor or angiotensin II receptor blocker, phosphate binder, vitamin D receptor antagonist, atrial fibrillation, gastric hemorrhage, cerebral infarction, and ischemic heart disease.</p><p>Logistic analysis between Proton Pump inhibitor use and hypomagnesemia.</p

Patient characteristics.

<p><i>P</i> values reflect group across differences. Abbreviations: H2,histamine 2; ACE-I, angiotensin converting enzyme inhibitor; ARB, angiotensin II receptor blocker. Conversion factors for units: serum creatinine in mg/dL to mol/L, *88.4; blood urea nitrogen in mg/dL to mmol/L,*0.357; Calcium in mg/dL to mmol/L,*0.2495; Phosphorus in mg/dL to mmol/L, *0.3229.</p><p>Patient characteristics.</p

Effect of diuretic use and hemodialysis vintage on association between acid suppressive therapy and serum magnesium.

<p>Abbreviation: H2, histamine-2. Reference category is patients on no acid-suppressive medications. β-coefficients ± s.e’s and <i>P</i> values are provided for each variable. Adjusted models includes age, dialysis vintage, sex, Diabetes mellitus, Kt/V, systolic blood pressure, albumin, potassium, C-reactive protein, sodium, blood urea nitrogen, parathyroid hormone, phosphorus, calcium, hemoglobin, furosemide, antiplatelet drug, vitamin K antagonist, angiotensin converting enzyme inhibitor or angiotensin II receptor blocker, phosphate binder, vitamin D receptor antagonist, atrial fibrillation, gastric hemorrhage, cerebral infarction, and ischemic heart disease.</p><p>Effect of diuretic use and hemodialysis vintage on association between acid suppressive therapy and serum magnesium.</p

Cox proportional hazard models.

<p>*Adjusted for age, gender, smoking status, primary tumor sites, postoperative stages, existence of residual tumor, and postoperative treatment with chemotherapy or radiotherapy.</p><p>HR, hazard ratio; CI, confidence interval.</p

Linkage disequilibrium plot across vitamin D receptor gene in 172 patients with HNSCC.

<p>Numbers within the diamonds are D′ values for the respective SNP pairs.</p

VDR haplotype (Cdx2, Fok<i>I</i>, and Apa<i>I</i>) frequencies and permutation analysis^*2.

*1<p>: Number of permutation was 10,000 times.</p>*2<p>: Analyses were performed using samples from 172 patients.</p

Patients' characteristics stratified by FokI genotype.

*1<p>: P-value was calculated by Mann Whitney test.</p>*2<p>: P-value was calculated by chi-square test.</p

Kaplan-Meier curves of progression-free survival by Fok<i>I</i> polymorphism in 204 patients with HNSCC.

<p>Difference in time until progression was compared between Fok<i>I</i> C/C plus C/T and T/T.</p

Differentiation of pyloric-gland type to fundic glands.

<p>(A) HE-stained image, showing proliferation of atypical glands associated with mildly enlarged nuclei. (B) Differentiation into fundic glands (pepsinogen-1). Tumor glands are positive for pepsinogen-1. (C) Differentiation into fundic glands (H,K-ATPase). Similar to pepsinogen-1, H,K-ATPase-positive cells can be seen in tumor glands.</p