Signal transduction in keratinocyte proliferation and differentiation

Keratinocytes, a key cellular component for both homeostasis and pathology of the skin, secrete a number of growth factors and cytokines, and their proliferation and differentiation are stimulated by a variety of biological factors. The major mechanism by which keratinocytes respond to extracellular signals is change in protein phosphorylation. In this review, we focus on factors known to influence keratinocyte proliferation and differentiation, such as epidermal growth factor family, nerve growth factor, transforming growth factor-β, insulin-like growth factor-1, keratinocyte growth factor, hepatocyte growth factor, cytokines. A hypothesis for a dual role of epidermal growth factor in keratinocyte proliferation and differentiation is proposed.Biomedical Reviews 1997; 8: 73-85

Rowell\u27s syndrome triggered by omeprazole

No abstract available</p

Psoriasis associated with vitiligo. Coexisting psoriasis and Vitiligo

Although the first case of psoriasis with vitiligo was reported in 1955, the pathogenesis of the association between these two dermatoses is still unknown (7). Herein, we report on a case of a 57-year-old man with coexisting vitiligo and psoriasis

Cutaneous manifestations of aortoiliac occlusive disease: two cases and review of the literature

Aortoiliac occlusive disease (AIOD) is non-inflammatory obstructive vasculopathy commonly affecting patients with advanced atherosclerosis, diabetes mellitus, or elevated cholesterol levels, and subjects with other risk factors such as cigarette smoking. Two Caucasian patients (a 55-year-old woman and a 56-year-old man), with ulcerous cutaneous lesions of AIOD are reported. In both cases, medical history comprises initial lower limb claudication, multiple painful ulcers along the legs and absence of superficial femoral artery pulse. Severe obstruction of both infrarenal aorta and iliac arteries on the left side was demonstrated by contrast angiography and Doppler ultrasonography. The evolution of the disease showed some characteristic findings, including pyoderma gangrenosum-like ulcerations as the initial cutaneous manifestation of AIOD, multiple painful ulcers along the lower extremities, and aorto-iliac occlusive disease due to atherosclerosis. Early diagnosis and surgical reconstruction of vessels in patients with AIOD improved quality of life and limb salvage rates

Polyamine metabolism changes in psoriasis

Introduction: Polyamines - putrescine, spermidine and spermine are polycationic compounds ubiquitous for all living organisms. They are essential for the cell growth and differentiation, the control of cell cycle progress, apoptosis, and cancerogenesis. Accumulated scientific evidence suggests the central role of polyamines in the process of keratinocytic proliferation, differentiation, and regulation. Objective: To elucidate the polyamine metabolic changes that occur in benign keratinocytic proliferation. Fifty eight patients were enrolled in the study, 31 with plaque-form of psoriasis vulgaris, which had been referred to as a model of benign keratinocytic proliferation, and 27-healthy controls. Materials and Methods: An original, innovative chromatographic method was used to detect the levels of putrescine, spermidine, and spermine in all skin samples. Results: Were significantly proven ( P < 0.05). No difference was found between the polyamines levels of non-lesional psoriatic skin and healthy controls. Psoriatic lesions showed a two-time higher concentration of all polyamines in lesional, compared to non-lesional skin. Spermine had the highest concentration and highest proliferation trend, which demonstrated the importance of propylamine synthesis in the pathogenesis of psoriasis. Spermine highest concentrations suggested the leading role of adenosine methionine decarboxylase (AMDC) in the pathogenesis of benign keratinocytic proliferations. Conclusions: Non-lesional skin in psoriatic patients did not show latent changes in polyamine metabolism. Psoriatic lesions demontrated two-time higher levels of the most essential biogenic polyamines compared to healthy controls. The highest level of spermine proved the crucial role of AMDC in the polyamine metabolism changes in psoriasis. Future therapeutic approaches should be focused on reduction of exogenic spermine intake, utilizing new spermine blockers, and synthesis of AMDC inhibitors