Quasispecies evolution in general mean-field landscapes

I consider a class of fitness landscapes, in which the fitness is a function of a finite number of phenotypic "traits", which are themselves linear functions of the genotype. I show that the stationary trait distribution in such a landscape can be explicitly evaluated in a suitably defined "thermodynamic limit", which is a combination of infinite-genome and strong selection limits. These considerations can be applied in particular to identify relevant features of the evolution of promoter binding sites, in spite of the shortness of the corresponding sequences.Comment: 6 pages, 2 figures, Europhysics Letters style (included) Finite-size scaling analysis sketched. To appear in Europhysics Letter

Functional Mobility Outcomes in Telehealth and In-Person Assessments for Wheeled Mobility Devices

The purpose of this study was to compare telehealth and in-person service delivery models for wheeled mobility devices in terms of functional outcomes. We hypothesized that clinically significant improvements in functional mobility measured by the Functional Mobility Assessment (FMA) will occur in individuals receiving both telehealth and in-person clinic evaluations. A total of 27 Veterans receiving telehealth visits were compared to 27 individuals seen in clinic, selected from a database, matching for age, gender, and primary diagnosis. All mean individual item and total FMA scores in both groups increased from Time 1 to Time 2. Within the telehealth group, all changes in individual item and total FMA scores were statistically significant, with changes in 8 of 10 items meeting threshold for clinical significance (change >1.85 points). Within the clinic group, changes in 7 of 10 individual items and total FMA scores were statistically significant, and these same 7 items met threshold for clinical significance. Change scores for individual item and total FMA scores did not differ significantly between the two groups. A larger and clinically significant change in transfer score was seen in the telehealth group, suggesting telehealth visits may confer an advantage in being able to assess and address transfer issues in the home

Fishes of the Charlotte Harbor Estuarine System, Florida

To date, 255 fish species in 95 families have been reliably reported from the Charlotte Harbor estuarine system in southwest Florida. The species list was compiled from recent fishery-independent collections, a review of reports and peer-reviewed literature, and examination of cataloged specimens at the Florida Museum of Natural History. Thirty-nine species are new records for this estuarine system. Many of the newly documented species are common on the west Florida continental shelf and associated inshore habitats. Twenty-two previously reported species were not included in the species list presented herein on the basis of more recent research, doubtful original identifications, or questionable locality data

Oxygen ion dynamics in the Earth's ring current: Van Allen probes observations

Oxygen (O+) enhancements in the inner magnetosphere are often observed during geomagnetically active times, such as geomagnetic storms. In this study, we quantitatively examine the difference in ring current dynamics with and without a substantial O+ ion population based on almost 6 years of Van Allen Probes observations. Our results have not only confirmed previous finding of the role of O+ ions to the ring current but also found that abundant O+ ions are always present during large storms when sym-H < -60 nT without exception, whilst having the pressure ratio () between O+ and proton (H+) larger than 0.8 and occasionally even larger than 1 when L < 3. Simultaneously, the pressure anisotropy decreases with decreasing sym-H and increasing L shell. The pressure anisotropy decrease during the storm main phase is likely related to the pitch angle isotropization processes. In addition, we find that increases during the storm main phase and then decreases during the storm recovery phase, suggesting faster buildup and decay of O+ pressure compared to H+ ions, which are probably associated with some species dependent source and/or energization as well as loss processes in the inner magnetosphere.Accepted manuscrip

Functional reorganisation and recovery following cortical lesions: A preliminary study in macaque monkeys.

Damage following traumatic brain injury or stroke can often extend beyond the boundaries of the initial insult and can lead to maladaptive cortical reorganisation. On the other hand, beneficial cortical reorganisation leading to recovery of function can also occur. We used resting state FMRI to investigate how cortical networks in the macaque brain change across time in response to lesions to the prefrontal cortex, and how this reorganisation correlated with changes in behavioural performance in cognitive tasks. After prelesion testing and scanning, two monkeys received a lesion to regions surrounding the left principal sulcus followed by periodic testing and scanning. Later, the animals received another lesion to the opposite hemisphere and additional testing and scanning. Following the first lesion, we observed both a behavioural impairment and decrease in functional connectivity, predominantly in frontal-frontal networks. Approximately 8 weeks later, performance and connectivity patterns both improved. Following the second lesion, we observed a further behavioural deficit and decrease in connectivity that showed little recovery. We discuss how different mechanisms including alternate behavioural strategies and reorganisation of specific prefrontal networks may have led to improvements in behaviour. Further work will be needed to confirm these mechanisms.This work was supported by the MRC intramural program MC-A060-5PQ10 (MA, DM, JD, AB), an MRC Career Development Award G0800329 (AM)

Intermediate outcomes after the Fontan procedure in the current era

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