Teacher Technology Self-Efficacy and its Impact on Instructional Technology Integration

This study is an extension of Slutsky’s (2016) dissertation about technology self-efficacy. The purpose of this study was to extend the generalization of the original study, considering the knowledge of teacher technology self-efficacy as it relates to integrating technology in the classroom. I built on previous research and added related knowledge to the original study. This study examined teacher levels of technology self-efficacy, identified specific factors affecting their current level, and examined the role and impact professional development opportunities have on technology self-efficacy

Toward a Critical History: Amherst H. Wilder Foundation

The Wilder Foundation—an organization more than a century old—has an identity and history linked to Minnesota's past, along with many other organizations that have served our community. As we seek to create the world we want to be part of, it is important to understand how the organization's origins, history, and role in community inform our work and relationships today.The following report was commissioned to better understand the critical influences of 19th century history upon the roots of our organization from an equity lens. The report documents key historical events in Minnesota's history, and outlines how Amherst H. Wilder and other wealthy industrialists accumulated wealth in the late 19th century through industries such as railroads, lumber, cattle, banking, construction, government contracting, and land speculation. The report examines the effect of these colonial industries—and Wilder's businesses specifically—on Indigenous people and highlights, when possible, the dependence of such industries on laborers who were enslaved or oppressed

Proposal to Implement a Peer Mentorship Program Project

California Polytechnic State University, San Luis Obispo’s College of Agriculture, Food and Environmental Science (CAFES) needs a peer mentor program modeled after the Orfalea College of Business’ (OCOB). Younger students who have mentors do exponentially better than students who do not. Upperclassmen gain a sense of fulfillment from helping younger, less experienced underclassmen. Rodger’s research provides insight into students’ academic success when paired with a peer mentor. Those who participated in a full year of peer mentoring had considerably higher grades than the control group. A specific group of students who benefit from programs like these are students who struggle with anxiety

Ethical Priority of the Most Actionable System of Biomolecules: the Metabolome

The metabolome is a system of small biomolecules (metabolites) and a direct result of human bioculture. Consequently, metabolomics is well poised to impact anthropological and biomedical research for the foreseeable future. Overall, we provide a perspective on the ethical, legal, and social implications (ELSI) of metabolomics, which we argue are often more alarming than those of genomics. Given the current mechanisms to fund research, ELSI beyond human DNA is stifled and in need of considerable attention.This publication was primarily supported by the NIH (RM1 HG009042; R01 GM089886). Open Access fees paid for in whole or in part by the University of Oklahoma Libraries.Ye

Proteomic analysis of secretagogue-stimulated neutrophils implicates a role for actin and actin-interacting proteins in Rac2-mediated granule exocytosis

<p>Abstract</p> <p>Background</p> <p>Neutrophils are abundant leukocytes that play a primary role in defence against pathogens. Neutrophils enter sites of infection where they eliminate pathogens via phagocytosis and the release of antimicrobial mediators via degranulation. Rho GTPases, particularly Rac2, play a key role in neutrophil degranulation. The purpose of this study was to identify Rac2-dependent changes in protein abundance in stimulated neutrophils.</p> <p>Methods</p> <p>We performed a proteomic analysis on secretagogue-stimulated bone marrow neutrophils that were isolated from wild-type and Rac2^-/-mice. Protein abundance was analyzed by 2-dimensional SDS-PAGE of fluorescently labelled samples which allowed the detection ~3500 proteins.</p> <p>Results</p> <p>We identified 22 proteins that showed significant changes in abundance after secretagogue-stimulation of wild-type neutrophils, which did not occur in neutrophils isolated from Rac2^-/-mice. As expected, the abundance of several granule proteins was reduced in wild-type cells; this did not occur in Rac2^-/-neutrophils which confirms the requirement for Rac2 in degranulation. We also found changes in abundance of many actin remodelling proteins including coronin-1A, β-actin and the F-actin capping protein, (CapZ-β). Coronin-1A showed elevated levels of several isoforms after stimulation of neutrophils from wild-type, but not from Rac2^-/-mice. These isoforms were immunoreactive with anti-phospho-threonine antibodies, suggesting that neutrophil stimulation triggers a Rac2-dependent kinase cascade that results in the phosphorylation of coronin-1A.</p> <p>Conclusion</p> <p>The control of Rac2-mediated degranulation in neutrophils likely functions through actin remodelling via activation of several actin-binding proteins. We found coronin-1A to be a novel downstream effector protein of this pathway that is threonine phosphorylated in response to secretagogue stimulation.</p

Implementation of the Joint Duty Program at CIA: Analysis and Recommendations

This report assesses the strengths and weaknesses of the Joint Duty (JD) program as it is currently implemented at the CIA. Over the course of approximately six weeks, the Bush School 2012 Capstone interviewed - in-person and by phone - 160 CIA employees who completed a JD assignment. In assessing the qualitative and quantitative responses reported by personnel, we conclude that employees find value in the program, are well-integrated within their host agency, and achieve the program's mission of increasing employees' knowledge of other Intelligence Community agencies. Weaknesses hindering the program include: a disproportionately high number of employees choosing assignments at the Office of Director of National Intelligence (ODNI) and the National Reconnaissance Agency (NRO); insufficient manager guidance in selecting career-relevant assignments; failure to comply with regulations tasking agencies to maintain contact with their JD employees; employees experiencing significant difficulty returning to the CIA upon completion of their assignment; and inconsistent views regarding whether the program aids promotion potential.The Center for the Study of Intelligenc

Targeting the Complement Serine Protease MASP-2 as a Therapeutic Strategy for Coronavirus Infections

MASP-2, mannose-binding protein-associated serine protease 2, is a key enzyme in the lectin pathway of complement activation. Hyperactivation of this protein by human coronaviruses SARS-CoV, MERS-CoV and SARS-CoV-2 has been found to contribute to aberrant complement activation in patients, leading to aggravated lung injury with potentially fatal consequences. This hyperactivation is triggered in the lungs through a conserved, direct interaction between MASP-2 and coronavirus nucleocapsid (N) proteins. Blocking this interaction with monoclonal antibodies and interfering directly with the catalytic activity of MASP-2, have been found to alleviate coronavirus-induced lung injury both in vitro and in vivo. In this study, a virtual library of 8736 licensed drugs and clinical agents has been screened in silico according to two parallel strategies. The first strategy aims at identifying direct inhibitors of MASP-2 catalytic activity, while the second strategy focusses on finding protein-protein interaction inhibitors (PPIs) of MASP-2 and coronaviral N proteins. Such agents could represent promising support treatment options to prevent lung injury and reduce mortality rates of infections caused by both present and future-emerging coronaviruses. Forty-six drug repurposing candidates were purchased and, for the ones selected as potential direct inhibitors of MASP-2, a preliminary in vitro assay was conducted to assess their interference with the lectin pathway of complement activation. Some of the tested agents displayed a dose-response inhibitory activity of the lectin pathway, potentially providing the basis for a viable support strategy to prevent the severe complications of coronavirus infections

First Year Student Success Initiative: Academic Support Services Working Group Report

Report from the Academic Support Services Working Group in response to the charge to: “Develop a set of recommendations about ways that student academic support services can better serve first-year students.” The report includes five recommendations for integrated academic supports