Gene-Gene Interactions in the Folate Metabolic Pathway and the Risk of Conotruncal Heart Defects

Conotruncal and related heart defects (CTRD) are common, complex malformations. Although there are few established risk factors, there is evidence that genetic variation in the folate metabolic pathway influences CTRD risk. This study was undertaken to assess the association between inherited (i.e., case) and maternal gene-gene interactions in this pathway and the risk of CTRD. Case-parent triads (n = 727), ascertained from the Children's Hospital of Philadelphia, were genotyped for ten functional variants of nine folate metabolic genes. Analyses of inherited genotypes were consistent with the previously reported association between MTHFR A1298C and CTRD (adjusted P = .02), but provided no evidence that CTRD was associated with inherited gene-gene interactions. Analyses of the maternal genotypes provided evidence of a MTHFR C677T/CBS 844ins68 interaction and CTRD risk (unadjusted P = .02). This association is consistent with the effects of this genotype combination on folate-homocysteine biochemistry but remains to be confirmed in independent study populations

Using the TEACHING WELL Model for Evaluation of Online Counselor Educators

As enrollment in online counselor education programs continues to grow, faculty must develop self-awareness regarding their own teaching practices. Research across various disciplines offers a variety of tools and strategies for best practices in online education, including how to effectively engage students and promote student success. The purpose of this article is to offer the TEACHING WELL Model as one practical option for online counselor educators to use as a self-evaluation or peer mentoring tool. The authors hope to offer a robust guide to streamline a process for faculty quality assurance and continued improvement in online counselor education programs

Gene-based genome-wide association studies and meta-analyses of conotruncal heart defects.

Conotruncal heart defects (CTDs) are among the most common and severe groups of congenital heart defects. Despite evidence of an inherited genetic contribution to CTDs, little is known about the specific genes that contribute to the development of CTDs. We performed gene-based genome-wide analyses using microarray-genotyped and imputed common and rare variants data from two large studies of CTDs in the United States. We performed two case-parent trio analyses (N = 640 and 317 trios), using an extension of the family-based multi-marker association test, and two case-control analyses (N = 482 and 406 patients and comparable numbers of controls), using a sequence kernel association test. We also undertook two meta-analyses to combine the results from the analyses that used the same approach (i.e. family-based or case-control). To our knowledge, these analyses are the first reported gene-based, genome-wide association studies of CTDs. Based on our findings, we propose eight CTD candidate genes (ARF5, EIF4E, KPNA1, MAP4K3, MBNL1, NCAPG, NDFUS1 and PSMG3). Four of these genes (ARF5, KPNA1, NDUFS1 and PSMG3) have not been previously associated with normal or abnormal heart development. In addition, our analyses provide additional evidence that genes involved in chromatin-modification and in ribonucleic acid splicing are associated with congenital heart defects

Organometallic mediated radical polymerization

Controlled radical polymerization has become increasingly important over the past decade and a half, allowing for the facile synthesis of specific macromolecular architectures with excellent control over the chemical and physical properties. This article presents an organized and detailed review of one particular CRP technique, organometallic mediated radical polymerization (OMRP), focusing on the individual catalysts developed, their efficacy and monomer scope. Rhodium, cobalt, molybdenum, osmium, iron, palladium, titanium, chromium and vanadium mediated radical polymerizations are presented alongside organo-main group mediated reactions. A separate section reviews the types of copolymers which have been synthesized using OMRP techniques. An attempt is made to unify the many disparate names which have previously been used for OMRP by virtue of the common mechanistic aspects displayed by the different catalyst systems. A mechanistic discussion highlights the similarities and differences between these systems and examines the interplay between reversible termination and degenerative transfer OMRP and competing 1-electron redox processes

Addressing Supervisee Anxiety During COVID-19: Applying Models of Supervision

Graduate counseling supervisees are experiencing unprecedented obstacles, compounding stressors, and heightened anxiety amidst the global COVID-19 pandemic. If not addressed, excessive anxiety can impede professional growth and limit the competence of future counselors. While theoretical-based models of supervision exist, the application of such models has not been fully explored in relation to addressing supervisee anxiety. Prompt and pointed action is needed from counseling supervisors, who are professionally and ethically responsible for training future counselors and the gatekeeping process. Three supervision models, including the Integrative Developmental Model, Solution-Focused Supervision, and Cognitive-Behavioral Supervision, are utilized to address heightened anxiety among counseling supervisees. Implications for counseling faculty supervisors and future research are included

The Transition Online: A Mixed-Methods Study of the Impact of COVID-19 on Students with Disabilities in Higher Education

Following the World Health Organization’s announcement of the global pandemic because of the Coronavirus Disease 2019, most Canadian universities transitioned to offering their courses exclusively online. One group affected by this transition was students with disabilities. Previous research has shown that the university experience for students with disabilities differs from those of their non-disabled peers. However, their unique needs are often not taken into consideration. As a result, students can become marginalized and alienated from the online classroom. In partnership with Student Accessibility Services, this research revealed the impact of the transition to online learning because of the pandemic for university students with disabilities. Students registered with Student Accessibility Services completed a survey about the effects of online learning during a pandemic on the students’ lives, education, and instructional and accommodation. It was clear from the results that online education during COVID-19 affected all aspects of the students’ lives, particularly to their mental health. This research provided a much-needed opportunity for students with disabilities to share the factors influencing their educational experience and identified recommendations instructors should consider when developing online courses to increase accessibility and improve engagement.Brock Library Open Access Publishing Fun

Pediatric ADHD symptom burden relates to distinct neural activity across executive function domains

Attention-deficit/hyperactivity disorder (ADHD) is a prevalent childhood disorder marked by inattention and/or hyperactivity symptoms. ADHD may also relate to impaired executive function (EF), but is often studied in a single EF task per sample. The current study addresses the question of unique vs. overlapping relations in brain activity across multiple EF tasks and ADHD symptom burden. Three in-scanner tasks drawn from distinct EF domains (cognitive flexibility, working memory, and inhibition) were collected from children with and without an ADHD diagnosis (N = 63). Whole-brain activity and 11 regions of interest were correlated with parent reports of inattention and hyperactivity symptoms. Across the three EF domains, brain activity related to ADHD symptom burden, but the direction and location of these associations differed across tasks. Overall, activity in sensory and default mode network regions related to ADHD, and these relations did not consistently overlap across EF domains. We observed both distinct and overlapping patterns for inattention and hyperactivity symptoms. By studying multiple EF tasks in the same sample, we identified a heterogenous neural profile related to attention symptom burden in children. Our results inform ADHD characterization and treatment and explain some of the variable brain results related to EF and ADHD reported in the literature