Clinical Outcomes of Antibiotic Use on Patients of Diabetic Foot Infection

Resiko amputasi dan resistensi bakteri terhadap antibiotik pada pasien infeksi kaki diabetik (IKD) masih merupakan masalah besar yang belum dapat diatasi. Penelitian bertujuan untuk mengevaluasi clinical outcomes penggunaan antibiotik pada pasien IKD di bangsal penyakit dalam rumah sakit X. Penelitian dilakukan selama 3 bulan dengan metode observasi prospektif longitudinal. Pasien dipilih berdasarkan diagnosa IKD dengan lama rawatan ≥ 3 hari. Total sampel yang diperoleh 30 pasien, perempuan 16 (53,3%) dan laki-laki 14 (46,7%). Tes kultur hanya dilakukan pada 5 (16,67%) pasien. Satu pasien menunjukkan tidak adanya bakteri patogen. Antibiotik yang paling sering digunakan adalah Ampisilin-sulbaktam. Berdasarkan clinical outcomes, 11 (36,7%) pasien membaik, 15 (50%) memburuk dan 4 (13,35%) meninggal. Berdasarkan statistik, jenis kelamin, umur, Indeks masa tubuh dan lama menderita DM tidak mempengaruhi clinical outcomes (P>0,05). Hasil penelitian yang diperoleh dapat disimpulkan bahwa antibiotik yang digunakan masih belum efektif dalam mencapai tujuan terapi.An amputation and antibiotic resistant bacteria on diabetic foot infection (DFI) are still big issue. The research aimed to evaluate clinical outcomes of antibiotic use among patients of DFI in internal medicine ward at Hospital X. An observation of prospective longitudinal methode was conducted during 3 months. Patients were selected based on diagnosis of DFI that had length of stay ≥ 3 days. Total samples were 30 patients, 16(53.3%) women and 14(46.7%) men. Only 5(16.67%) patients who did culture and sensitivity. One of them with no pathogen bacteria. The most frequently antibiotic use was ampicillin-sulbactam. Based on clinical outcomes, 11(36,7%) improve, 15(50%) worse, and others were passed away. Based on statistic, there were no influence among clinical outcomes with gender, age, BMI and duration of diabetes. Therefore based on the research, antibiotics use were still not effective to achieve desired outcomes