41 research outputs found
JEJUNAL INFUSION OF GLYCOCHENODEOXYCHOLIC (GCDC) AND GLYCOCHOLIC (GC) ACIDS ALTER SMALL-BOWEL MOTILITY AND TRANSIT IN MAN
Alkaline intra-oesophageal pH in peptic oesophagitis: is it really caused by gastro-oesophageal reflux?
Alkaline intraoesophageal pH and gastro-oesophageal reflux in patients with peptic oesophagitis
Simultaneous 22-h measurements of intra-oesophageal and intragastric pH were made in 22 patients with symptoms of gastro-oesophageal reflux (7 with peptic oesophagitis, 8 with peptic oesophageal stricture, and 7 with peptic oesophagitis and previous partial gastrectomy) to determine whether alkaline intra-oesophageal pH is a consequence of alkaline gastro-oesophageal reflux. In the three groups of patients intra-oesophageal pH was greater than 7 for 16.9 +/- 4.8%, 27.5 +/- 7.6%, and 21.0 +/- 7.7%, respectively, of total recording time (p = NS). Intragastric pH greater than 7 was recorded only in the patients with partial gastrectomy (10.3 +/- 5.3% of recording time; p less than 0.01 in comparison with the other groups). Elevations of intra-oesophageal pH to greater than 7 never occurred during episodes of alkalinization of intragastric pH. These results suggest that refluxed fluids are unlikely to be the cause of alkaline intra-oesophageal pH in patients with peptic oesophagiti
Are bile acids involved in the regulation of mounth-to-caecum transit time (MCTT) in man?
Feedback regulation of transit and motility in the human jejunum and ileum by ileal infusion of glycochenodeoxycholic acid (GCDC)
The effect of eradication of Helicobacter pylori on gastric and output in patients with duodenal ulcer
Effect of cholecystectomy on mounth-to-caecum transit of a liquid meal
Mouth-to-cecum transit and serum bile acid profile after ingestion of a lactulose-labeled liquid meal (440 kcal) were measured in eight patients with gallstones and a radiologically functioning gallbladder before and three to five months after cholecystectomy and in 15 controls. In the patients mouth-to-cecum transit was longer after the operation, 87.5 +/- 18.5 (mean +/- SEM) min vs 57.5 +/- 9.7 min (P less than 0.05). Mouth-to-cecum transit times before and after the operation were not different from controls (58.0 +/- 6.7 min). Serum bile acid AUCs were similar (P = NS) in patients and controls, while total bile acid and cholylglycine fasting concentrations were higher after cholecystectomy (P less than 0.05 and P less than 0.01 respectively). Cholecystectomy prolongs mouth-to-cecum transit of a liquid mea