Wide local resection of sacral chordoma through posterior midline approach

This study was performed in 21 patients with sacral chordoma from July 2008 to June 2017 and posterior surgical approach was used for resection. Out of 21 patients, 12 had done subtotal sacrectomy and the remaining 9 had done partial sacrectomy. Their follow-up periods were at least five years. Operative time ranged between two to four hours. All patients recovered well from operation and two to five units of blood transfusion were needed for each. After operation, majority of the patients developed some bowel and bladder dysfunction and five patients developed wound infection. During the follow-up, two patients had tumor recurrence and one patient expired two years after operation. The remaining 18 patients were tumor-free at the 5-years follow-up. Wide surgical resection via the posterior midline approach could be a good management plan for the sacral chordoma. However, complete removal with surgical margin varies according to the location of the tumor

DFT and Molecular Docking Studies of an Antiviral Drug: Molnupiravir

810-812This paper presents computational analysis of molnupiravir, the first orally administered antiviral drug approved by MHRA for the cure of COVID-19. Molnupiravir is the derivative of N4-hydroxycytidine with a ribose residue attached to an isobutyrate ester group. Method based on DFT has been employed to establish the optimised structure, electronic and optical parameters of the drug molecule. Further, molecular docking of molnupiravir on SARS-CoV-2 protein, glucocorticoid receptor (PDB ID: 1M2Z) has been performed so as to examine the preferred affinity and binding pattern of the drug

Wide local resection of sacral chordoma through posterior midline approach

This study was performed in 21 patients with sacral chordoma from July 2008 to June 2017 and posterior surgical approach was used for resection. Out of 21 patients, 12 had done subtotal sacrectomy and the remaining 9 had done partial sacrectomy. Their follow-up periods were at least five years. Operative time ranged between two to four hours. All patients recovered well from operation and two to five units of blood transfusion were needed for each. After operation, majority of the patients developed some bowel and bladder dysfunction and five patients developed wound infection. During the follow-up, two patients had tumor recurrence and one patient expired two years after operation. The remaining 18 patients were tumor-free at the 5-years follow-up. Wide surgical resection via the posterior midline approach could be a good management plan for the sacral chordoma. However, complete removal with surgical margin varies according to the location of the tumor

Evaluation of result of lumbar laminoplasty for multilevel lumbar canal stenosis

The aim of our study is to evaluate the clinical and functional outcome following lumbar laminoplasty with posterior element reconstruction with mini-plate and screws for multilevel lumbar canal stenosis. This study was done on 40 patients (18 males and 22 females) of degenerative multilevel lumber canal stenosis patients underwent open double door lumbar laminoplasty with posterior element reconstruction with mini-plate and screws from January 2015 to June 2018. Thirty four patients underwent surgery for 2 level involvement and 6 underwent for 3 level involvement of lumbar canal stenosis. The mean post-operative hospital stay was 5.2 ± 1.1 days. Per-operative complication was dural tear in 2 cases. Pre-operative mean VAS score of back pain and leg pain were 7.0 ± 0.7 and 7.2 ± 1.1 which were significantly reduced to 1.0 ± 0.2 and 1.0 ± 0.8 respectively at final follow-up. All patients were followed-up for minimum 1 year. Pre-operative mean Japanese Orthopedic Association score was 8.6 ± 2.2 which was significantly increased to 14.8 ± 0.4 after 12 months of surgery. Pre-operative mean Oswestry Disability Index was 34.4 ± 3.0 which was significantly reduced to 8.5 ± 2.2 after 12 months of surgery. The outcome of lumbar laminoplasty with posterior element reconstruction with mini-plate and screws for multilevel lumbar canal stenosis show good result and can be one of the good option for the treatment for multilevel lumbar canal stenosis

Wide local resection of sacral chordoma through posterior midline approach

This study was performed in 21 patients with sacral chordoma from July 2008 to June 2017 and posterior surgical approach was used for resection. Out of 21 patients, 12 had done subtotal sacrectomy and the remaining 9 had done partial sacrectomy. Their follow-up periods were at least five years. Operative time ranged between two to four hours. All patients recovered well from operation and two to five units of blood transfusion were needed for each. After operation, majority of the patients developed some bowel and bladder dysfunction and five patients developed wound infection. During the follow-up, two patients had tumor recurrence and one patient expired two years after operation. The remaining 18 patients were tumor-free at the 5-years follow-up. Wide surgical resection via the posterior midline approach could be a good management plan for the sacral chordoma. However, complete removal with surgical margin varies according to the location of the tumor

Bacillus-based nano-bioformulations for phytopathogens and insect–pest management

Abstract Background Recent concerns linked with the application of chemical pesticides and the increasing necessity of low inputs sustainable agriculture have put the use of microbial biocontrol agents and bio-pesticides to the forefront for their application against plant pathogens and insect–pest management. Results This review tended to scrutinize the prospects of microbial biocontrol agents and microbes-based nano-formulations against plant diseases and for pest management with emphasis on bacteria-based nanoparticles, especially derived from Bacillus species. It also tended to discuss the probable mechanism of action and effect on plant growth along with its prospects in a brief manner. Conclusion The use of microbial biocontrol agents offers effective, eco-friendly, and long-lasting management of plant diseases. The employment of nanotechnology in the field of biopesticides has emerged as a promising solution. Nano-biopesticides in the form of biologically derived active pesticides or compounds integrated as nanoparticles and integrated into a suitable polymer have application in insect–pest management. </jats:sec