AM841 (0.1 mg/kg, i.p.) injected once daily for 7 days did not alter DSS-induced colitis in (A) CB1^-/-, (B) CB2^-/- (C) and CB1/CB2^-/- mice.

<p>Figure shows data for macroscopic score and MPO activity. $p<0.05,$$$p<0.001, as compared with control animals. Data represent means ± SEM, n = 6–8.</p

Protective effect of AM841 (0.01, 0.1 and 1 mg/kg, i.p.) injected once daily for 7 days on DSS-induced colitis in mice.

<p>Figure shows data for (A) macroscopic score, (B) MPO activity, (C) body weight, (D) representative micrographs for hematoxylin and eosin staining of colon wall sections (i, control; ii, DSS; iii, DSS+AM841 0.01 mg/kg; iv, DSS+AM841 0.1 mg/kg; v, DSS+AM841 1 mg/kg; scale bar = 100 µm) and (E) microscopic score. $$$p<0.001, as compared with control animals. *p<0.05, ***p<0.001, as compared with DSS-treated mice. Data represent means ± SEM, n = 6–8.</p

Protective effect of CB 13 after central (0.1 µg/animal, i.c.v, OD), but not peripheral (0.1 mg/kg, i.p., OD) administration for 3 days on TNBS-induced colitis in mice.

<p>Figure shows data for (A) macroscopic score, (B) MPO activity and (C) ulcer score. **p<0.01, as compared with TNBS-treated mice. Data represent means ± SEM, n = 6–8.</p

Protective effect of AM841 (0.1 mg/kg, i.p.) injected once daily for 3 days on TNBS-induced colitis in mice.

<p>Figure shows data for (A) macroscopic score, (B) MPO activity, (C) ulcer score and (D) body weight. $$$p<0.001, as compared with control animals. **p<0.01, ***p<0.001, as compared with TNBS-treated mice. Data represent means ± SEM, n = 6–8.</p

Chemotactic assay with murine neutrophils.

<p>AM841 (0.1–100 nM) inhibited neutrophil migration to 10 nM fMLP in a concentration-dependent manner. $p<0.05,$$$p<0.001, as compared with vehicle-treated controls. Data represent means ± SEM of 4 independent experiments performed in duplicate.</p

Therapeutic effect of AM841 (0.1 mg/kg, i.p.) injected once or twice daily from day 4 on DSS-induced colitis in mice.

<p>Figure shows data for (A) macroscopic score, (B) MPO activity and (C) body weight. $$p<0.01,$$$p<0.001, as compared with control animals. *p<0.05, **p<0.01, as compared with DSS-treated mice. Data represent means ± SEM, n = 6–8.</p