Validation of Fully Automated VMAT Plan Generation for Library-Based Plan-of-the-Day Cervical Cancer Radiotherapy

<div><p>Purpose</p><p>To develop and validate fully automated generation of VMAT plan-libraries for plan-of-the-day adaptive radiotherapy in locally-advanced cervical cancer.</p><p>Material and Methods</p><p>Our framework for fully automated treatment plan generation (Erasmus-iCycle) was adapted to create dual-arc VMAT treatment plan libraries for cervical cancer patients. For each of 34 patients, automatically generated VMAT plans (autoVMAT) were compared to manually generated, clinically delivered 9-beam IMRT plans (CLINICAL), and to dual-arc VMAT plans generated manually by an expert planner (manVMAT). Furthermore, all plans were benchmarked against 20-beam equi-angular IMRT plans (autoIMRT). For all plans, a PTV coverage of 99.5% by at least 95% of the prescribed dose (46 Gy) had the highest planning priority, followed by minimization of V_45Gy for small bowel (SB). Other OARs considered were bladder, rectum, and sigmoid.</p><p>Results</p><p>All plans had a highly similar PTV coverage, within the clinical constraints (above). After plan normalizations for exactly equal median PTV doses in corresponding plans, all evaluated OAR parameters in autoVMAT plans were on average lower than in the CLINICAL plans with an average reduction in SB V_45Gy of 34.6% (<i>p</i><0.001). For 41/44 autoVMAT plans, SB V_45Gy was lower than for manVMAT (<i>p</i><0.001, average reduction 30.3%), while SB V_15Gy increased by 2.3% (<i>p</i> = 0.011). AutoIMRT reduced SB V_45Gy by another 2.7% compared to autoVMAT, while also resulting in a 9.0% reduction in SB V_15Gy (<i>p</i><0.001), but with a prolonged delivery time. Differences between manVMAT and autoVMAT in bladder, rectal and sigmoid doses were ≤ 1%. Improvements in SB dose delivery with autoVMAT instead of manVMAT were higher for empty bladder PTVs compared to full bladder PTVs, due to differences in concavity of the PTVs.</p><p>Conclusions</p><p>Quality of automatically generated VMAT plans was superior to manually generated plans. Automatic VMAT plan generation for cervical cancer has been implemented in our clinical routine. Due to the achieved workload reduction, extension of plan libraries has become feasible.</p></div

Measured treatment delivery times for autoVMAT and autoIMRT using the MLCi2 and Agility MLCs.

<p>Measured treatment delivery times for autoVMAT and autoIMRT using the MLCi2 and Agility MLCs.</p

Percentage differences in mean OAR plan parameter values for all evaluated planning strategies, compared to autoVMAT.

<p><b>(a) for all 44 plans, (b) and (c) for the 10 patients with large bladder filling induced PTV displacements.</b> Positive values point at an advantage for autoVMAT. ^*: difference with autoVMAT is statistically significant. Average absolute values for autoVMAT: SB V_45Gy = 15.4%, SB V_15Gy = 68.7%, SB D_mean = 25.5 Gy, Bladder D_mean = 43.5 Gy, Rectum D_mean = 42.9 Gy, Sigmoid D_mean = 42.3 Gy and CI_95% = 1.174.</p