C-Reactive Protein As A Response Indicator In Drug-Naïve Patients With Major Depressive Disorder: A Hospital-Based Study

Abstract Objective: C-reactive protein (CRP) is an indicator of the inflammatory process in the body, and is associated with the pathogenesis of depression through its purported effect on neurotransmitter function in the brain. Current research aims to study the relationship between the levels of CRP and the rate of remission of major depressive disorder with first-line antidepressant therapy. Methods: This hospital-based prospective study included thirty patients by purposive sampling technique. Patients with first-episode MDD with no history of antidepressant exposure and other medical comorbidity were recruited for pharmacotherapy with escitalopram, a first-line antidepressant. Patients taking antidepressants, anti-inflammatory medicines, having co-morbid conditions or other psychiatric conditions were excluded. The baseline CRP levels were measured and depressive symptoms were evaluated using the Hamilton Rating Scale for Depression (HRSD) at weeks 0, 6 and 12. The patients with low (≤5 mg/l) and high (>5 mg/l) CRP levels were compared for remission rates at week 12 using Kaplan–Meier survival analysis. Results: Amongst the 30 cases, 11(36.7%) were males and 19(63.3%) were female patients. The mean age was 35.95±7.85 years. Both groups were matched concerning age, gender, BMI and baseline HRSD score (p>0.05). As per Kaplan–Meier survival analysis, a significantly higher proportion of patients had remission of MDD at the 12th week having CRP levels ≤5 mg/l than the patients with CRP levels >5 mg/dl (p=0.002). Conclusion: This research concluded that after an adequate trial with a standard antidepressant, higher levels of CRP could lead to poorer remission rates in MDD subjects and could represent a sub-group of patients with treatment resistance

High-power laser testing of calcium-phosphate-based bioresorbable optical fibers

Silica optical fibers are employed in endoscopy and related minimally invasive medical methods thanks to their good transparency and flexibility. Although silicon oxide is a biocompatible material, its use involves a serious health risk due to its fragility and the fact that potential fiber fragments can freely move inside the body without the possibility of being detected by conventional methods such as X-ray imaging. A possible solution to this issue can be the development of optical fibers based on bioresorbable (i.e., biodegradable and biocompatible) materials, which exhibit the important benefit of not having to be explanted after their functionality has expired. The optical power transmission tests of recently developed single-mode (SM) and multi-mode (MM) bioresorbable optical fibers based on calcium-phosphate glasses (CPGs) are here reported. A continuous-wave (CW) fiber laser at 1080 nm with output power up to 13 W and picosecond laser sources at 515 and 1030 nm with MW pulse peak power were used to test the transmission capabilities of the CPG fibers. No degradation of the CPG fibers transmission under long-term illumination by CW laser was observed. A laser-induced damage threshold (LIDT) at a fluence higher than 0.17 J/cm2 was assessed with the picosecond laser sources

Burnout among surgeons before and during the SARS-CoV-2 pandemic: an international survey

Background: SARS-CoV-2 pandemic has had many significant impacts within the surgical realm, and surgeons have been obligated to reconsider almost every aspect of daily clinical practice. Methods: This is a cross-sectional study reported in compliance with the CHERRIES guidelines and conducted through an online platform from June 14th to July 15th, 2020. The primary outcome was the burden of burnout during the pandemic indicated by the validated Shirom-Melamed Burnout Measure. Results: Nine hundred fifty-four surgeons completed the survey. The median length of practice was 10 years; 78.2% included were male with a median age of 37 years old, 39.5% were consultants, 68.9% were general surgeons, and 55.7% were affiliated with an academic institution. Overall, there was a significant increase in the mean burnout score during the pandemic; longer years of practice and older age were significantly associated with less burnout. There were significant reductions in the median number of outpatient visits, operated cases, on-call hours, emergency visits, and research work, so, 48.2% of respondents felt that the training resources were insufficient. The majority (81.3%) of respondents reported that their hospitals were included in the management of COVID-19, 66.5% felt their roles had been minimized; 41% were asked to assist in non-surgical medical practices, and 37.6% of respondents were included in COVID-19 management. Conclusions: There was a significant burnout among trainees. Almost all aspects of clinical and research activities were affected with a significant reduction in the volume of research, outpatient clinic visits, surgical procedures, on-call hours, and emergency cases hindering the training. Trial registration: The study was registered on clicaltrials.gov "NCT04433286" on 16/06/2020

Investigation of nanosecond and femtosecond pulsed laser deposition and application of some metal nanoparticle films

THESIS 9924Pulsed laser deposition (PLD) is a convenient and flexible technique which can be applied to all elemental and compound solids. In conventional PLD a nanosecond (ns) laser is used to ablate the surface of a solid target and a small amount of material expands rapidly from the target as an ionised vapour plume. Condensation of the plume on a non-wetting substrate, together with surface diffusion, leads to the formation of a nanoparticle film; the thickness is controlled by the number of laser pulses. On the other hand with femtosecond (fs) laser irradiation, very rapid heating leads to nanoscale fragmentation of a small amount of target material. Nanoparticles are expelled from the target and can be captured on a substrate. In the present work we have studied the ns- and fs-PLD of some noble and transition metals in vacuum for laser fluence well above the ablation threshold (-1.5 J cm -2). A range of techniques such as Langmuir ion probe, the time and space resolved fast imaging and optical emission spectroscopy and electron microscopy was applied to characterize the laser ablation plumes and to study the morphology of nanoparticle films

Sliding on snow of Aisi 301 stainless steel surfaces treated with ultra-short laser pulses

Surface irradiation of AISI 301 with ultra-short linearly polarized pulses between 247 fs and 7 ps resulted in laser induced periodic surface structures (LIPSS). Scanning electron microscope micrographs taken after the laser treatment show the formation of sub-micrometer sized arrays of nearly parallel ripples slightly differing from each other, depending on the specific treatment adopted. Static contact angle data indicate that LIPSS induce a marked hydrophobic behavior of the treated surfaces. The friction coefficient of laser treated and pristine AISI 301 surfaces gliding on compact snow was compared to that of ultra-high molecular weight polyethylene. The friction coefficients of the laser treated samples are intermediate between those of bare AISI 301 and of UHMWPE. The changes in contact angle and surface morphology of the samples after extensive tribometer tests were tested to investigate the durability of LIPSS

Merging of Bi-Modality of Ultrafast Laser Processing: Heating of Si/Au Nanocomposite Solutions with Controlled Chemical Content

Ultrafast laser processing possesses unique outlooks for the synthesis of novel nanoarchitectures and their further applications in the field of life science. It allows not only the formation of multi-element nanostructures with tuneable performance but also provides various non-invasive laser-stimulated modalities. In this work, we employed ultrafast laser processing for the manufacturing of silicon–gold nanocomposites (Si/Au NCs) with the Au mass fraction variable from 15% (0.5 min ablation time) to 79% (10 min) which increased their plasmonic efficiency by six times and narrowed the bandgap from 1.55 eV to 1.23 eV. These nanostructures demonstrated a considerable fs laser-stimulated hyperthermia with a Au-dependent heating efficiency (~10–20 °C). The prepared surfactant-free colloidal solutions showed good chemical stability with a decrease (i) of zeta (ξ) potential (from −46 mV to −30 mV) and (ii) of the hydrodynamic size of the nanoparticles (from 104 nm to 52 nm) due to the increase in the laser ablation time from 0.5 min to 10 min. The electrical conductivity of NCs revealed a minimum value (~1.53 µS/cm) at 2 min ablation time while their increasing concentration was saturated (~1012 NPs/mL) at 7 min ablation duration. The formed NCs demonstrated a polycrystalline Au nature regardless of the laser ablation time accompanied with the coexistence of oxidized Au and oxidized Si as well as gold silicide phases at a shorter laser ablation time (<1 min) and the formation of a pristine Au at a longer irradiation. Our findings demonstrate the merged employment of ultrafast laser processing for the design of multi-element NCs with tuneable properties reveal efficient composition-sensitive photo-thermal therapy modality

Breast Lumps Presenting During Pregnancy

Background: To evaluate the frequency and time ofpresentation of benign and malignant breast lumps amongpregnant females.Methods: In this descriptive study all pregnant femaleswith a complaint of lump in breast were included . Tripleassessment was done for each patient (examination oflump, ultrasound for patients under 40 years,mammography for those above 40 years and fine needleaspiration cytology).Results: Out of 78 pregnant females, with complaintsof breast lump, 47 (60.25%) were found to have breastlumps and 31 (38.75%) had pregnancy induced changes.Majority of the patients (85.1%) had benign breast disease.Out of seven patients (14.9%) with malignant breastdisease, three (4.3%) were primigravidas as compared topatients with benign breast disorders where only 6 out of40 cases (15%) were primigravidas. Mean age of patientswith benign breast disease was 27 years (range 15-40 years)and mean age of those with malignant lumps was 35years( range 29-43 years). Approximately 51% of all lumpspresented during first and second trimester and restduring third trimester . On histopathological examinationall malignant lumps proved to be intraductal carcinomas.Conclusion: The incidence of breast lumps duringpregnancy is slightly higher (14.9%) than in non-pregnantfemales although majority of breast lumps duringpregnancy are benign

Laser-Treated Steel Surfaces Gliding on Snow at Different Temperatures

With the goal of substituting a hard metallic material for the soft Ultra High Molecular Weight Polyethylene (UHMWPE) presently used to make the bases of skis for alpine skiing, we used two non-thermodynamic equilibrium surface treatments with ultra-short (7–8 ps) laser pulses to modify the surface of square plates (50 × 50 mm2) made of austenitic stainless steel AISI 301H. By irradiating with linearly polarized pulses, we obtained Laser Induced Periodic Surface Structures (LIPSS). By laser machining, we produced a laser engraving on the surface. Both treatments produce a surface pattern parallel to one side of the sample. For both treatments, we measured with a dedicated snow tribometer the friction coefficient µ on compacted snow at different temperatures (−10 °C; −5 °C; −3 °C) for a gliding speed range between 1 and 6.1 ms−1. We compared the obtained µ values with those of untreated AISI 301H plates and of stone grinded, waxed UHMWPE plates. At the highest temperature (−3 °C), near the snow melting point, untreated AISI 301H shows the largest µ value (0.09), much higher than that of UHMWPE (0.04). Laser treatments on AISI 301H gave lower µ values approaching UHMWPE. We studied how the surface pattern disposition, with respect to the gliding direction of the sample on snow, affects the µ trend. For LIPSS with pattern, orientation perpendicular to the gliding direction on snow µ (0.05) is comparable with that of UHMWPE. We performed field tests on snow at high temperature (from −0.5 to 0 °C) using full-size skis equipped with bases made of the same materials used for the laboratory tests. We observed a moderate difference in performance between the untreated and the LIPSS treated bases; both performed worse than UHMWPE. Waxing improved the performance of all bases, especially LIPSS treated