Time of Mating and Incidence of Conception and Implantation in the Post Partum Lactating Female Mouse

A thesis presented to the faculty of the School of Sciences and Mathematics at Morehead State University in partial fulfillment of the requirements for the Degree of Master of Science in Biology By Paul A. Walter on July 23, 1973

The Embryonic Viability of the Constant Estrus Mouse

A thesis presented to the faculty of the School of Sciences and Mathematics at Morehead State University in partial fulfillment of the requirements for the Degree of Master of Science in Biology by Claudia M. Hicks on July 8, 1971

Rate of litter survival from stressed mothers through the F₃ generation

Call number: LD2668 .T4 1966 H671Master of Scienc

Oxygen consumption of the uterus, and the action of oestrin thereon

A method has been described for measuring the oxygen consumption of plain muscle, such as the uterus, by suspending it in oxygen in specially shaped bulbs connected with a Barcroft manometer.Measured according to this method, the oxygen consumption of the rabbit's uterus is 0.56 c.c., that of the guinea pig 0.53 c.c. and that of the rat 1.01 c.c. per gram moist weight per hour. (Volumes calculated as dry gas at N.T.P.).But the observed thickness of these uteri is shown to be greater than that which, according to Warburg's and Hill's formulae, would allow an adequate diffusion of oxygen right through the substance of the muscle.The uterus of the immature mouse as well as the adult in dioestrus and the castrated animal is sufficiently thin to permit of an adequate diffusion of oxygen when suspended in this gas.The oxygen consumption of the dioestrous 'uterus of the mouse is about 1.70 -1.80 c.c. per gram per hour; that of the castrated animal is slightly less.Under the conditions of the experiments no rise in oxygen use has been noticed in natural oestrus and when oestrus is induced in the spayed animal. But the figures are not conclusive as the radius of the uterus in this state has been found to be greater than the "critical radius" of Hill.(8) -57- The oxygen consumption of the dioestrous 'uterus of the mouse is about 1.70 -1.80 c.c. per gram per hour; that of the castrated animal is slightly less. Under the conditions of the experiments no rise in oxygen use has been noticed in natural oestrus and when oestrus is induced in the spayed animal. But the figures are not conclusive as the radius of the uterus in this state has been found to be greater than the "critical radius" of Hill. A noticeable increase in oxygen consumption, however, occurs in the uterus of the immature mouse during oestrus induced by injection of the oestrus - producing hormone, the average being about 2.300 c.c. or about 23 per cent. above that of the dioestrous uterus. The increase begins at pro - oestrus and is sustained until the declining stage is reached. This increase occurs in spite of the fact that the uterus. is too thick to allow proper diffusion of oxygen.-57- The oxygen consumption of the dioestrous 'uterus of the mouse is about 1.70 -1.80 c.c. per gram per hour; that of the castrated animal is slightly less. Under the conditions of the experiments no rise in oxygen use has been noticed in natural oestrus and when oestrus is induced in the spayed animal. But the figures are not conclusive as the radius of the uterus in this state has been found to be greater than the "critical radius" of Hill. A noticeable increase in oxygen consumption, however, occurs in the uterus of the immature mouse during oestrus induced by injection of the oestrus - producing hormone, the average being about 2.300 c.c. or about 23 per cent. above that of the dioestrous uterus. The increase begins at pro - oestrus and is sustained until the declining stage is reached. This increase occurs in spite of the fact that the uterus. is too thick to allow proper diffusion of oxygen. This phenomenon cannot be utilised as a means of standardising oestrin as the response is not graded and the technique is too laborious.Doses ranging from 12 to 20 r.u. of oestrin not only produce vaginal cornification but also uterine distension.The tremendous increase in size of the uterus during oestrus is not due to a great increase in the percentage of water content of the uterus

Insertional mutation of the hairless locus on mouse Chromosome 14

Crosses between heterozygous transgenic mice from line 5053 produced offspring with progressive irreversible hair loss beginning at day 10. With increasing age, the skin of these animals became thicker and plicated in appearance. Histological analysis revealed the complete absence of normal hair follicles and numerous intradermic cystic structures, which enlarged with time and became filled with keratinaceous material. Test crosses demonstrated that the affected animals are homozygous for the transgene insertion. The clinicla and histological phenotype of the new mutant closely resembles that of the rhino allele at the hairless locus on Chromosome (Chr) 14. Complementation tests and linkage analysis indicate that the transgene has interrupted the hairless locus. It has been demonstrated previously that mutation at the hr locus is accompanied by a variety of immune deficiencies. Many of the older affected transgenic mice developed an impetigo-like skin eruption which responded to antibiotic ointment and which may reflect impaired immune function. The transgenic allele, hr TgN5053Mm , will be useful for identification of the transcription unit of the hairless locus.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/47000/1/335_2004_Article_BF00360900.pd

Общая линия жизни и репрезентация успешности в автобиографиях и автобиографических интервью женщин-ученых

На основе методов и материалов устной истории, автобиографий и интервью представлена реконструкция повседневной жизни российских женщин-учены

The physiology of pregnancy in the rat

1. THE PHYSIOLOGY OF PREGNANCY IN THE RAT.-I. THE PROLONGATION AND INTERRUPTION OF PREGNANCY. By ANNIE MELDRUM HAIN From the Department of Animal Genetics, University of Edinburgh. (With eight tables.) QUATERLY JOURNAL OF EXPERIMENTAL PHYSIOLOGY. VOL. XXII. No.3 (Issued 13th December 1932). 2. THE PHYSIOLOGY OF PREGNANCY IN THE RAT. FURTHER DATA BEARING ON THE PROLONGATION OF PREG-NANCY, WITH A STUDY OF THE EFFECTS OF OÖPHORECTOMY DURING PREGNANCY. By ANNIE M. HAIN (Carnegie Research Scholar), The Institute of Animal Genetics, University of Edinburgh. (Received for publication 1st March 1933.) 3. THE PHYSIOLOGY OF PREGNANCY IN THE RAT: AN HORMONAL INVESTIGATION INTO THE MECHANISM OF PARTURITION. EFFECT ON THE FEMALE RAT OF THE ANTE-NATAL ADMINISTRATION OF OESTRIN TO THE MOTHER . By ANNIE MELDRUM HAIN (CARNEGIE RESEARCH FELLOW). Institute of Animal Genetics, University of Edinburgh. QUATERLY JOURNAL OF EXPERIMENTAL PHYSIOLOGY. VOL. 25. No.2 (Issued July 1935). 4. THE PHYSIOLOGY OF PREGNANCY IN THE RAT: FURTHER DATA ON THE PASSAGE OF HORMONES VIA THE PLACENTA AND THE MOTHER’S MILK. By ANNIE MELDRUM HAIN (CARNEGIE RESEARCH FELLOW). Institute of Animal Genetics, University of Edinburgh. QUATERLY JOURNAL OF EXPERIMENTAL PHYSIOLOGY. VOL. 26. No.1 (Issued April 1936). 5. THE EFFECT OF SUCKLING ON THE DURATION OF PREGNANCY IN THE RAT (WISTAR ALBINO) BY A. M. HAIN, PH.D. (Carnegie Research Scholar.) (Institute of Animal Genetics, University of Edinburgh.) (Received loth December, 1933.) REPRINTED FROM THE JOURNAL OF EXPERIMENTAL BIOLOGY, VOL. XI, No. 3, pp. 279 -282, JULY 1934 6. EFFECT UPON LACTATION OF OÖPHORECTOMY DURING PREGNANCY. (ALBINO RAT.) By ANNIE M. HAIN (Carnegie Research Scholar). Institute of Animal Genetics, University of Edinburgh. QUATERLY JOURNAL OF EXPERIMENTAL PHYSIOLOGY. 1934. (Received for publication 1st March 1933.) 7. THE EFFECT (a) OF LITTER -SIZE ON GROWTH AND (h) OF OESTRONE ADMINISTERED DURING LACTATION (RAT). By ANNIE M. HAIN (Carnegie Research Fellow). From the Institute of Animal Genetics, University of Edinburgh. . QUATERLY JOURNAL OF EXPERIMENTAL PHYSIOLOGY. VOL. 25. No.4 (Issued December 1935). 8. An Effect on the Rat of Antenatal and Postnatal Administration of OEstrin BY A. M. HAIN, Ph.D. Carnegie Research Fellow, Institute of Animal Genetics, Edinburgh. Reprinted from the EDINBURGH MEDICAL JOURNAL, NEW SERIES (IVth), VOL. XLII., 1935 9. INCREASE IN WEIGHT OF THE MOTHER AND OF THE TUTUS DURING PREGNANCY (RAT). By ANNIE M. HAIN. From the Macaulay Laboratory, Institute of Animal Genetics, Edinburgh University. QUATERLY JOURNAL OF EXPERIMENTAL PHYSIOLOGY. VOL. XXII. No.1 (Issued 26th MAY 1932). 10. COMPARATIVE ASSAY OF OESTRONE IN THE RAT AND THE MOUSE A. M. HAIN AND J. M. ROBSON, From the Institute of Animal Genetics and the Department of Pharmacology, University of Edinburgh Received for publication April 2, 1936. Reprinted from THE JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS Vol. 57, No. 4, August, 1936 ("The Assay of Oestrone in the Rat and the Mouse." by L. M. Hain and J.M. Robson. N.B. The Assay on the Rat was done entirely by A.M. Hain; that on the Mouse by J. M. Robson) 11. SPONTANEOUS "DECIDUOMATOUS TUMOURS" _ IN THE PSEUDOPREGNANT RAT. By ANNIE M. HAIN. From the Macaulay Laboratory, Institute of Animal Genetics, Edinburgh University. QUATERLY JOURNAL OF EXPERIMENTAL PHYSIOLOGY. VOL. XXII. No.1 (Issued 26th May 1932). 12. SOME FACTS REGARDING GROWTH OF THE WISTAR RAT UNDER STANDARD CONDITIONS IN BRITAIN (DERIVATIVE EDINBURGH STOCK) 1 A. M. HAIN Institute of Animal Genetics, University of Edinburgh. Reprinted from THE ANATOMICAL RECORD Vol. 59, No. 3, June, 1934 13. CONGENITAL UROGENITAL ANOMALIES IN RATS INCLUDING UNILATERAL RENAL AGENESIA BY A. M. HAIN AND EDWIN M. ROBERTSON REPRINTED FROM THE JOURNAL OF ANATOMY VOL, LXX, PART IV, JULY 193

The importance of place: A history of genetics in 1930s Britain

My thesis develops the concept of 'settings' for genetics research in 1930s Britain. It shows that settings were associated with stable 'types' of genetics. I establish what these types were and how they remained stable by comparing three characteristics of genetics (funding, research organism, problem choice) at two locations in different settings. I begin by showing that the Department of Zoology/Biometry (DoZ/B) and the Institute of Animal Genetics (IAG) exemplified locations in two of the three settings for genetics study in 1930s Britain: the academic and breeding settings respectively. I also examine how the settings developed between 1900 and 1940. My study of funding demonstrates that the DoZ/B had a closer relationship to the Rockefeller Foundation than the IAG. This was mainly due to research quality, because both locations undertook academic activities. Nevertheless, bodies that funded breeding locations, including the IAG, tended to support applied research, while academic locations generally struggled to gain external funding. My study of research organisms reveals that wild and laboratory organisms were used to gain information about generic organisms at academic locations. At breeding locations domesticated organisms were used to gain information specific to a small group of organisms. I demonstrate that operational behaviour towards organisms also differed between the settings. Finally, I show that problem choice involved the selection of both organism and research area in the breeding setting, but of just research area in the academic setting. Research areas were more synthetic in the academic setting, with the possible exception of cytogenetics. These features of genetics formed the 'types' associated with the breeding and academic settings. The types' differed in both content and the relationship between different characteristics. This relationship was a lot closer in breeding setting than the academic, but provided stability to 'types' in both