Spectrophotometric Determination of L-Ascorbic Acid in Pharmaceuticals Based on Its Oxidation by Potassium Peroxymonosulfate and Hydrogen Peroxide

Two new, accurate, precise, and sensitive spectrophotometric methods were developed for the assay of L-ascorbic acid in pharmaceutical preparations. The determination of L-ascorbic acid was based on its oxidation by potassium peroxymonosulfate (method A) and hydrogen peroxide in the presence of Cu(II) as a catalyst (method B). The molar absorptivities were found to be 1.48×104 and 1.06×104 L mol–1 cm–1 for methods A and B, respectively. Beer\u27s law was obeyed in the concentration range of 0.65–11.20 μg mL–1 for method A and 0.51–16.00 μg mL–1 for method B. Other compounds commonly found in vitamin C and multivitamin products did not interfere with the determination of L-ascorbic acid.. The proposed methods were successfully applied for the determination of L-ascorbic acid in pharmaceutical formulations. The results obtained with the proposed methods showed good agreement with those given by the titrimetric method using iodine

Determination of L-Ascorbic Acid in Pharmaceutical Preparations Using Direct Ultraviolet Spectrophotometry

A new, selective and accurate direct ultraviolet spectrophotometric method was developed for the determination of L-ascorbic acid in pharmaceuticals. The oxidation of L-ascorbic acid by iodate in an acidic medium was used as a means of correcting for background absorption. The molar absorptivity of the proposed method was found to be 8.71x103 dm3 mol-1 cm-1 at 250 nm. Beer’s law was obeyed in the concentration range of 0.46 – 16.00 μg cm-3 for L-ascorbic acid. The relative standard deviation was 0.67 % for a concentration of 8.00 μg cm-3 of ascorbic acid (n = 7). The ingredients commonly found in vitamin C and multivitamin products did not interfere. The proposed procedure was successfully applied to assays of L-ascorbic acid in pharmaceutical preparations. The results obtained with the proposed method showed good agreement with those given by the titrimetric method using iodine

Determination of L-Ascorbic Acid in Pharmaceutical Preparations Using Direct Ultraviolet Spectrophotometry

A new, selective and accurate direct ultraviolet spectrophotometric method was developed for the determination of L-ascorbic acid in pharmaceuticals. The oxidation of L-ascorbic acid by iodate in an acidic medium was used as a means of correcting for background absorption. The molar absorptivity of the proposed method was found to be 8.71x103 dm3 mol-1 cm-1 at 250 nm. Beer’s law was obeyed in the concentration range of 0.46 – 16.00 μg cm-3 for L-ascorbic acid. The relative standard deviation was 0.67 % for a concentration of 8.00 μg cm-3 of ascorbic acid (n = 7). The ingredients commonly found in vitamin C and multivitamin products did not interfere. The proposed procedure was successfully applied to assays of L-ascorbic acid in pharmaceutical preparations. The results obtained with the proposed method showed good agreement with those given by the titrimetric method using iodine

Direct Spectrophotometric Determination of L-ascorbic Acid in the Presence of Potassium Cyanide

A simple and highly sensitive direct spectrophotometric method was developed for the determination of L-ascorbic acid. Potassium cyanide (9.21x10-5 mol dm-3) was used to stabilize ascorbic acid in aqueous medium. The molar absorptivity of the proposed method, which does not require an extraction procedure, was 1.38x104 dm3 mol-1 cm-1 at 264 nm. Beer’s law was obeyed in the concentration range of 0.26 – 12.0 μg ascorbic acid cm-3. Th e relative standard deviation was 1.40 % for the determination of 8.0 μg ascorbic acid cm-3 (n = 7). The substances commonly found in vitamin C products do not interfere with the determination of ascorbic acid. Other vitamins and organic acids interfere. The proposed procedure was successfully applied to the determination of ascorbic acid in pure form and vitamin C preparations

Removal of lead and zinc ions from their monocomponent and two-component aqueous solutions using sodium hydroxide

The hydroxide precipitation method, using NaOH as a precipitant agent, was conducted to treat synthetic monocomponent and two-component water solutions of Pb2+ and Zn2+ with initial concentrations of 50 and 500 mg/l of each metal. The effect of pH and initial concentration of lead and zinc ions on their removal were investigated. The precipitation experiments were carried out by batch method that involves the mixing of NaOH with solutions containing metal ions to occur nucleation, solid growth and subsequent separation of precipitates from solution by filtration. The results showed that the removal efficiency was increased by increasing of pH and initial concentration of metal ions in their water solutions. Hydroxide precipitation method using NaOH is an ef-ficient technique for the removal of lead and zinc ions from their monocomponent and two-component water so-lutions of different concentrations, with maximum removal efficiency in the pH range of 10.32 to 11.39

The Importance of Determination of some Physical – Chemical Properties of Wheat and Flour

The content of the some ingredients, such as proteins, ash, etc. is important in food products, either they are present in raw materials or in final products. As wheat is also very important food raw material, and flour as the fi nal product of milling, it is important to know their specific physical – chemical properties. The importance of knowing the physical and chemical properties of wheat and flour is due to the determination of quality and kind of fl our which is produced after milling process. In this work, some physical – chemical properties are determined and some comparations of characteristics were performed in both wheat and flour. Characteristics that were observed in this work are moisture content, ash content, protein content, Zeleny sedimentation value, gluten content and water adsorption values. On the base of results obtained in this work, some conclusions are made that could be useful for milling industry