Inhibition of wild type, I436N and L315H glucokinase proteins by human GKRP.

<p>Data are shown as mean ±SEM, and were obtained from 4 independent measurements. Independent t-tests were used to ascertain differences between GKRP-mediated inhibition of both mutants versus that obtained with the wild-type GCK enzyme.</p

Clinical and biochemical parameters of Slovakian <i>GCK</i> mutation carriers.

<p>Data are presented as median values (range).</p>*<p>Data only available for 35 probands.</p>#<p>Data only available for 33 probands.</p>$<p>For the remaining 32 subjects, diabetes/impaired glucose tolerance was not detected prior to genetic testing.</p><p>BMI = body mass index, HbA1c = glycated hemoglobin A1c, HDL = High Density Lipoprotein, OHA = oral hypoglyceamic agents.</p

<i>GCK</i> mutations identified in Slovakian probands with a phenotype of GCK-MODY.

<p>All sequence information is based on GenBank reference sequence NM_000162.3. Nucleotide numbering reflects cDNA position, with +1 corresponding to the A of the major start codon of exon 1a (present in the pancreatic isoform). Y = yes, N = no.</p