Base case demographics, annual transition probabilities, and SVR probabilities per treatment scenario.

<p>Base case demographics, annual transition probabilities, and SVR probabilities per treatment scenario.</p

Cost-effectiveness frontier of DAA-treatment strategies among PWID compared to PegIFN/RBV^a. Strategy 2: DAA/RBV (G2-3) & dual DAA (g1-4); 3: Dual DAA for all genotypes; 4: Dual DAA with a 3x higher treatment uptake.

<p>a The strategies that fall below the dashed blue line are strategies that fall bellow a willingness to pay threshold reflecting 1 GDP per head of the population, i.e., €38,255 for the Netherlands, and are considered highly cost-effective compared to PegIFN/RBV. However, scenarios are compared incrementally to identify the <i>most</i> cost-effective strategy. The most cost-effective strategy is shown on the “cost-effectiveness frontier”, the line that is closest to the X-axis.</p

Correlations between any two linked individuals in the same network tree.

<p>Correlations between any two linked individuals in the same network tree.</p

Effective contact rates <i>C</i>.

<p>Effective contact rates <i>C</i>.</p

Cumulative discounted costs, effects, and incremental cost-effectiveness ratios of four Hepatitis C treatment strategies in a declining epidemic and a stable HCV epidemic.

<p>Cumulative discounted costs, effects, and incremental cost-effectiveness ratios of four Hepatitis C treatment strategies in a declining epidemic and a stable HCV epidemic.</p

Characteristics of study participants and recruitment.

<p>(<b>A</b>) Recruitment options used by participants. (<b>B</b>) Distribution of participants over waves (in proportions of country totals). The lines indicate the proportion of participants, in each wave, who also invited recruitees (these participants requested four invitations on the last page of the survey). In both countries the proportion of seeds (wave 0) that invited recruitees was more than 70%, and on average more than half of all participants invited one or more recruitees. (<b>C</b>) The age distributions in each country for all participants, with colour indicating sex. The solid lines (black) display the age distributions for seeds only. The blue dotted lines show the estimated Dutch and Thai population estimates for 2012. (<b>D</b>) The household sizes reported by participants in each country (bars). The squares (for the Netherlands) and triangles (Thailand) show the household sizes as reported by the national census bureaus. The lines in the graph indicate the number of household members with one or more symptoms (as a proportion of the country totals), as reported by participants (30 participants in the Netherlands did not known whether household members had any symptoms, compared to 20 in Thailand).</p

Who has contact with whom?

<p>The green coloured plots on the left are all based on data collected in the Netherlands and purple coloured plots on the right on data collected in Thailand. Plots in (<b>A</b>) display for each age group the proportion of reported contact persons that were younger, the same age or older than the participants. Displayed values are proportions that were calculated separately for the categories “contact persons while eating” and “contact persons at different locations”. The brighter coloured cells indicate higher proportions. (<b>B</b>) The contact intensity matrices for recruiter-recruitees pairs with respect to age (displayed as proportions of country totals) and (<b>C</b>) degree (displays actual reported degree; outliers above 150 are not displayed). The brighter coloured cells/points in B-C illustrate higher contact recruitment rates and the darker cells/points lower rates.</p

Egocentric contact data.

<p>(<b>A</b>) Box and whisker plot showing the median, quartiles and 95 percentiles of numbers of contact persons reported by participants for travelling, at different locations and while eating, during weekdays (WD, Monday-Friday) and weekend days (WE, Saturday-Sunday). Dutch sample is indicated in green and Thai sample in purple. (<b>B</b>) Distribution of the overall reported numbers of contact persons (“degree”) in each country. The green solid line (the Netherlands) and the dotted purple line (Thailand) indicate the fitted negative binomial distributions for reported degree. (<b>C</b>) Quantile-Quantile plot of the degree distributions displayed in plot 3B. (<b>D</b>) The probability estimates of inviting recruitees (“intention to recruit”) as a function of degree, specified by sex (and additionally adjusted for variables age, education and household size). Dotted lines indicated confidence intervals (95%). Values were obtained using logistic regression analysis for the full sample and the sample excluding seeds (i.e. sample without wave 0).</p

Correlations between directly linked individuals in one component.

<p>^a One case who reported >500 household contacts was removed.</p><p>^b Based on total number of self-reported symptoms by each respondent.</p

Recorded contacts.

<p>(<b>A</b>) Distribution of reported degree, the line indicates the fitted negative binomial distribution; (<b>B</b>) degree by day of the week (outliers >200 are not shown); (<b>C</b>) contacts while travelling with mass transport (sky train, subway and/or airplane), bus/minibus/shuttle boot, car/taxi and/or motorbike/tuk-tuk (outliers >40 are not shown); (<b>D</b>) numbers of contacts at different locations (outliers >80 are not shown). School was defined as ‘school/university’, ‘restaurant’ includes contacts at coffee shop, and ‘other’ is the sum of contacts encountered at sport/leisure, concert and ‘other places’. Above each plot in B, C and D the mean and SD (in blue) are displayed and within each plot the median (in red); B also contains the number of observations. Plots in C and D are based on an equal number of observations (n = 221).</p