Correlation of serum uric acid and proteinuria in patients with type 2 diabetes mellitus

Background: Diabetes mellitus is one of the most common and important metabolic diseases worldwide. Hperuricemia is associated with kidney damage manifested by glomerular hypertrophy and sclerosis. The aim of this study was evaluation of association between serum uric acid level and proteinuria in patients with type 2 diabetes mellitus. Methods: A total of 140 patients (48 men and 92 women) with type 2 diabetes mellitus were enrolled in the study. Demographic criteria as age, body mass index, serum uric acid level and 24 hours urine protein were measured in these patients. Finding: Mean of patients age was 59.8 ± 10 years. Uric acid level in patients with significant proteinuria (≥ 500 mg/24 h) and mild proteinuria (< 500 mg/24 h) were 6.70 ± 1.82 and 5.06 ± 1.46 mg/dl respectively (P < 0.001). Serum uric acid level had positive correlation with 24 hours urine protein, duration of diabetes and insulin treatment. Conclusion: In type 2 diabetes mellitus, serum uric acid level has positive correlation with proteinuria; so uric acid maybe has a role in progression of diabetic nephropathy

Overview of medicinal plants used for cardiovascularsystem disorders and diseases in ethnobotany of differentareas in Iran

Background and Aims: Today, cardiovascular diseases are the prominent cause of death in&nbsp;industrialized countries which include a variety of diseases such as hypertension, hyperlipidemia,&nbsp;thromboembolism, coronary heart disease, heart failure, etc. Recent research findings haveshown that not only the extent of cultivation and production of medicinal plants have not beenreduced, but also day-to-day production and consumption have increased. In traditional botanicalknowledge, herbal medicines are used for the treatment of cardiovascular disorders. In this study,we sought to gather and report medicinal plants used to treat these diseases in different regionsof Iran.Methods: The articles published about ethnobotanical study of cardiovascular diseases in variousregions of Iran, such as Arasbaran, Sistan, Kashan, Kerman, Isfahan Mobarakeh, Lorestan andIlam were prepared and summarized.Results: The results of ethnobotanical studies of various regions of Iran, such as Arasbaran, Sistan,Kashan, Kerman, Isfahan Mobarakeh, Lorestan and Ilam were gathered. The results showed thatsumac plants, barberry, yarrow, wild cucumber, horsetail, Eastern grape, hawthorn, wild rose,spinach, jujube, buckwheat, chamomile, chicory, thistle, Mary peas, nightshade, verbena, sorrel ,cherry, citrullus colocynthis, Peganum harmala, sesame and so many other plants are used for thetreatment of cardiovascular diseases and disorders.Conclusion: Herbal medicines are used effectively for some cardiovascular diseases. Rigoroustraining of patients to take precautions and drug interactions into account and to avoid thearbitrary use of medicinal plants is very important

A comprehensive review on Allium hirtifolium Boiss as a medicinal and edible plant

Medicinal plants are native legacies with universal and global significance that are considered as one of the most valuable assets of each country. To gain knowledge of these plants is one of the most important indicators of development in any countries. Study of medicinal plants in any region is very important for different potentials of these plants such as pharmacologic and industrial aspects. Regarding recent interest in and lack of information on medicinal plants, their therapeutic properties, and the approaches to their preparation and extraction, native information and traditional knowledge could contribute significantly to initiating scientific investigations on these plants. Therefore, it is necessary to take significant measures to use and promote systematic methods of utilization of these valuable resources by knowing these plants and obtaining necessary information about their habitats, ecological characteristics, and therapeutic uses. In this article, the latest scientific information on Allium hirtifolium, a medicinal, industrial and edible plant, is presented

Review on feverfew, a valuable medicinal plant

Background and Aims: Feverfew (Tanacetum parthenium) is a valuable medicinal plant from&nbsp;Asteraceae family with various pharmacological and therapeutic properties. In this article we&nbsp;reviewed the various aspects of feverfew including botanical characteristics, cultivation and&nbsp;production and medicinal and clinical uses.Material and Methods: Google Scholar, PubMed, EBSCO, Directory of open access journals&nbsp;(DOAJ), EMBASE, and Web of Science were searched using the keywords feverfew and&nbsp;parthenolide.&nbsp;Results: The essential oil of feverfew is frequently used in pharmaceutical and cosmetic industries.&nbsp;Parthenolide is the most important active component of feverfew that is used for the treatment of a&nbsp;wide variety of diseases such as fever, migraine headache, and rheumatoid arthritis.Conclusion: &nbsp;Feverfew has several positive clinical uses and has the potential to be considered as a&nbsp;new drug for the treatment of some diseases

A comparative study on hypoglycemic properties, lipid profile and bioactive components of hydro-alcoholic extracts of cooked and raw Brassica napus.

Introduction: Many plants with anti-oxidant properties proved to be effective on diabetes treatment. Brassica napus (turnip) is an anti-oxidant plant consumed raw or cooked. In this study, we examined and compared hypoglycemic and hypolipidemic properties of raw and cooked Brassica napus in diabetic rats. Objectives: Due to measuring bioactive component of Brassica napus as a rich source of flavonoid we investigate the hypoglycemic properties in raw and cooked type. Material and Methods: For this experimental study, 50 male Wistar rats weighing 200-250 g were designated into five groups of 10 consist of control, diabetic control, diabetic cooked turnip, diabetic raw turnip, and diabetic glibenclamide. The alloxan-induced diabetic rats received extracts orally for 4 weeks. Then, the serum biochemical factors were measured and compared statisticaly by analysis of variance (ANOVA) test. Results: Serum glucose, triglyceride (TG), cholesterol, and low density lipoprotein cholesterol (LDL-C) were significantly decreased in cooked and raw turnip rats compared to control ones. Cooked and raw Brassica napus extracts both helped high density lipoprotein cholesterol (HDL-C) increase; cooked turnip competency was superior in view of cholesterol and LDL-C decrease as well as HDL-C increase (P < 0.05). The mean difference in glucose and TG decrease was not significant between diabetic cooked turnip and diabetic raw turnip rats. Conclusion: Improving the blood glucose and lipid levels diabetic rats, in this study, may indicate that both raw and cooked Brassica napus extracts (especially the cooked one) may be beneficial in diabetic patients

Impacts of Hibiscus esculentus extract on glucose and lipid profile of diabetic rats.

Introduction:Hibiscus esculentus is capable to produce various molecules including phenolic and flavonoid compounds, phytosteroids with antioxidant property. Therefore, it has the potential to show antidiabetic activities. Objectives: This study was aimed to evaluate the impacts of Hibiscus esculentus extract on glucose and lipid profile of diabetic rats. The flavonoid, flavonol and phenolic components, as well as antioxidant activity of Hibiscus esculentus was also evaluated. Materials and Methods: In a preclinical study, 40 male Wistar rats were designated into four 10-member groups, i.e., control, diabetic control, diabetic Hibiscus esculentus, and diabetic glibenclamide. The Alloxan-induced diabetic rats received extracts orally for four weeks. Then, the serum biochemical factors were measured and compared by analysis of variance (ANOVA). Results: Serum glucose, triglyceride (TG), cholesterol, and low density lipoprotein cholesterol (LDL-C) were significantly decreased and high density lipoprotein cholesterol (HDL-C) increased in diabetic Hibiscus esculentus rats compared to diabetic control ones (P < 0.05). Conclusion: Improving the blood glucose and lipid profile in diabetic rats indicates that Hibiscus esculentus extract might be beneficial in diabetic patients

A study on the association of diabetic dermopathy with nephropathy and retinopathy in patients with type 2 diabetes mellitus

Background: Diabetic dermopathy is one of the most prevalent skin complications in diabetes patients. Some studies have pointed to association of diabetic dermopathy with retinopathy and nephropathy in patients with type 2 diabetes as microangiopathy presentations, but no rigorous study has been conducted to confirm this association. Objectives: This study investigated association of diabetic dermopathy with nephropathy and retinopathy in patients with type 2 diabetes referring specialty clinic of Shahrekord. Patients and Methods: This descriptive, cross-sectional study was conducted on 102 type 2 diabetes patients with dermopathy referring clinic constantly or as outpatient. Dermatological and ophthalmological examinations and examination for nephropathy were done for all patients. Demographic data and results of examinations and patients history, and biochemical tests were gathered and recorded by researcher developed checklists. Results: Mean age of patients was 83.8 2.60 years, of whom 64 (63.7%) were female and 37.3% were male. Prevalence of retinopathy in patients was 4.31% and nephropathy 3.33%. In this study, significant associations of diabetic dermopathy with diabetic nephropathy (P = 0.001), with retinopathy (P 0.05). Conclusions: Results of this study confirm the association of diabetic dermopathy with retinopathy and nephropathy in patients with type 2 diabetes. Since dermopathy is usually developed before retinopathy and nephropathy, dermopathy could be used as a clinical finding in early diagnosis and prevention of retinopathy and nephropathy in diabetes patients. © 2016 The Author(s)

Family satisfaction from point of view of diabetic and non-diabetic pares

Background: Family satisfaction in subpopulations referred to the endocrine clinic including diabetic and non diabetic patients and their spouses are compared in the present study. This study also assesses the correlation between family satisfaction and variables such as age, sex, educational level, economic status, type of diabetes, duration of the disease, type of therapy and dosage of drugs. A comparison of the frequency of sexual dysfunction between diabetics and non-diabetic pairs was also done. Methods: In this case- control study, 400 subjects were selected as simplified non-randomized method from outpatients referred to the Shahre Kord endocrine clinic in 2002. We assigned samples to group I (diabetic patients, n=100), group II (diabetic patients spouses, n=100), group III (non-diabetic patients, n=100) and group IV (non-diabetic patients spouses, n=100). Groups I and II were similar in sex, socioeconomic status and educational level. GRIMS family relationship questionnaire was used to evaluate family satisfaction. Results: Family satisfaction for diabetics in comparison with non-diabetics (P=0.05), diabetics in comparison with their spouses (P=0.003), and non-diabetics in comparison with their spouses (p=0.002) were significantly less. There was no significant difference between family satisfaction in diabetic and non-diabetic patients spouses (p>0.05). Relative frequency of sexual dysfunction was 76 and 29 and relative frequency of decreased libido was 32 an 12, in diabetic and non-diabetic couples, respectively. Family satisfaction was less in patients with diabetes type I and whom using higher dosage of drugs. Conclusion: This study emphasized on the attention to the family as a part of approach to the diabetic patients. According to our results, it is recommended to focus the most attention in this field to the patients with type I diabetes and who consume more amounts of drugs

A case of carbamazepine induced systemic lupus erythematous (SLE)

ABSTRACT Carbamazepine is an anticonvulsant drug that used to treat seizures and nerve pain and such as most drugs have side effect. Systemic lupus erythematous is one of connective tissue disorders that often caused by an auto immune mechanism of unknown, although some drugs cause SLE. This report aimed to demonstrate the carbamazepine induced SLE after its oral consumption for Convulsion. This is the report carbamazepine- induced systemic lupus in a 16-year-old patient who had been treated with

Effect of green tea on inflammation and oxidative stress in cisplatin-induced experimental liver function

Introduction: Cisplatin is one of the most potent chemotherapeutic antitumor drugs. Also, oxidative stress has been established to be involved in cisplatin-induced toxicity. Therefore, the present study was undertaken to examine the antioxidant and anti-inflammation potential of green tea hydroalcoholic extract (GTE) against the liver function of cisplatin in male rats.Methods: Adult male Wistar rats (180&ndash;250 g) were divided into 4 groups (n = 5) treated as follows: (1) control group (saline solution, 1 ml kg&minus;1 body weight, i.p.), cisplatin group (7 mg kg&minus;1 body weight, i.p.). Animals of Groups III received only green tea extract (30 mg/kg/day, by gavage). Group IV was given green tea extract+ cisplatin once daily for 24 hours. Liver function was evidenced in the cisplatin group by the increased serum levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST). The mechanism of cisplatin induced liver function was considered as being decreased the total antioxidant power (TAP). Systemic inflammation was assessed by tumor necrosis factor-alpha (TNF-&alpha;) levels.Results: A decrease in TAP level in cisplatin group was observed compared with control group. GTE administration decreased TNF-&alpha; and increased TAP compared to cisplatin group, but showed no significant differences between groups.Conclusion: The results suggested that green tea could ameliorate cisplatin liver function in rats through reduction of oxidative toxic stress and inflammation