EVALUATION OF THE QUALITY AND AVAILABILITY FOR IRRIGATION OF WATER FROM DIFFERENT SOURCES FROM SOUTHERN OLTENIA

The researches were carried out under the conditions of 2019 and aimed at assessing the quality and availability for irrigation of groundwater and surface water from different sources located on the territory of Dabuleni Research Development Station for Plant Culture on Sands (Dabuleni RDSPCS). The results regarding the quality of the water showed different values according to the source and climatic conditions. The average values regarding the fixed mineral residue, pH, nitrate content and ammonium ions, determined in 9 working points, show that the analyzed sources cannot be used as drinking water, but can be used for irrigation of agricultural crops. The obtained results showed the following water quality indicators: mineral residue = 475 -1350 mg / dm3; pH = 7.05 - 8.43; nitrates = 10.23 - 28.08 mg / dm3, ammonium (NH4 +) = 1.73 - 8.82 mg/dm3

Dissimilar Laser Welding of AISI 321 and AISI 1010

This paper presents the dissimilar laser welding of AISI 321 stainless steel and AISI 1010 carbon steel thin sheets in butt joint geometry using a 1 kW diode laser. Influence of the welding speed on the geometry and microstructure of the joints is discussed. Structural characterisation of the welds is realised through optical, electron microscopy and EDS analysis, observing distinct mixed and unmixed areas in the weld bead because of the high cooling rate. The weld bead presents an austenitic-martensitic-ferrite structure, characterized by austenitic twin grains with ferrite particles precipitated on grain boundaries, and islands comprising a ferrite-martensite structure. Chromium and nickel migration in the weld bead area was observed. Good tensile behaviour of the dissimilar joints was obtained, as all the specimen failure occurs far-off the weld zone

Preparation and investigation of mefenamic acid-polyethylene glycol-sucrose ester solid dispersions

Mefenamic acid (MA) is a widely used non-steroidal anti-inflammatory (NSAID) drug. The adverse effects typical of NSAIDs are also present in the case of MA, partly due to its low water solubility. The aim of this study was to increase the water solubility of MA in order to influence its absorption and bioavailability. Solid dispersions of MA were prepared by the melting method using polyethylene glycol 6000 and different types (laurate, D-1216; palmitate, P-1670; stearate, S-1670) and amounts of sucrose esters as carriers. The X-ray diffraction results show that MA crystals were not present in the products. Dissolution tests carried out in artificial intestinal juice showed that the product containing 10 % D-1216 increased water solubility about 3 times. The apparent permeability coefficient of MA across human Caco-2 intestinal epithelial cell layers was high and, despite the difference in solubility, there was no further increase in drug penetration in the presence of the applied additives

Reversed phase HPLC for strontium ranelate: Method development and validation applying experimental design

A reverse-phase HPLC (RP-HPLC) method was developed for strontium ranelate using a full factorial, screening experimental design. The analytical procedure was validated according to international guidelines for linearity, selectivity, sensitivity, accuracy and precision. A separate experimental design was used to demonstrate the robustness of the method. Strontium ranelate was eluted at 4.4 minutes and showed no interference with the excipients used in the formulation, at 321 nm. The method is linear in the range of 20–320 μg mL–1 (R2 = 0.99998). Recovery, tested in the range of 40–120 μg mL–1, was found to be 96.1–102.1 %. Intra-day and intermediate precision RSDs ranged from 1.0–1.4 and 1.2–1.4 %, resp. The limit of detection and limit of quantitation were 0.06 and 0.20 μg mL–1, resp. The proposed technique is fast, cost-effective, reliable and reproducible, and is proposed for the routine analysis of strontium ranelate

Extractability of polyphenols from black currant, red currant and gooseberry and their antioxidant activity

In this study, we analyzed extracts of Ribes (black currant, red currant and gooseberry) fruits obtained with methanol, methanol 50% and water. For each extract total polyphenol content, total flavonoid content and total anthocyanin content was assessed. The antioxidant activity of extracts was evaluated by 1,1-Diphenyl-2-picrylhydrazyl (DPPH) and 2,2’-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) radical scavenging capacity and by the photo-chemiluminescence (PCL) method. Identification and quantification of individual phenolic compounds was performed by means of high performance liquid chromatograph coupled with diode array detector (HPLC-DAD) analyses. From each fruit, best extraction of polyphenols was obtained with methanol 50%. In case of red currants and gooseberry there was no significant difference in flavonoids and anthocyanins extraction rate by the different extraction solvents. For black currants the methanol and methanol 50% extract presented the highest antioxidant activity. For red currants extracts with methanol 50% showed stronger antioxidant activity (IC50 = 5.71 mg/ml for DPPH, IC50 = 1.17 mg/ml for ABTS) than those with methanol or water. In case of gooseberry by the DPPH test the water extract proved to be the most active (IC50 = 5.9 mg/ml). In the PCL test black currants methanol 50% extract was over 6 times more powerful as the ones from red currants. In case of gooseberries, water extract presented the highest antioxidant activity (41.84 μmol AAE/g). In black currant cyanidin-3-glucoside was the major compound. Quercetin 3-O-glucoside was identified in each sample. From cinnamic acid derivatives neochlorogenic acid was present in black currants in the highest amount (356.33 μg/g)

Nitrones: not only extraordinary spin traps, but also good nitric oxide sources in vivo

Free radicals are involved in the development of reperfusion injuries. Using a spin trap, the intensity of such lesions can be reduced. Nitrones (effective in vivo spin traps) were tried in this work as in vivo nitric oxide donors. Nitrite and nitrate concentration values (rabbit blood) were used as biomarkers of nitric oxide production. Most nitrones did not increase plasma concentrations of nitrite and nitrate; on the contrary, reduced plasma concentrations of these indicators were noted. However, glyoxal isopropyldinitrone, in a dose of 50 mg kg–1, was highly effective in increasing nitric oxide production. In the same time, nitrones do not react with hepatic homogenates, proving that the release of nitric oxide takes place in the tissues and is not related to hepatic metabolism. Before using nitrones in vivo, they were tested in vitro for the ability to release nitric oxide following a reaction with the hydroxyl radical

Entrepreneurial Coordinator Management of Individual Career Planning of the Organizations in Romania

As a topical theme, career management is a permanent component of society, being closelyrelated to factors of everyday existence. This is because most of the population is interested andresponsible for their own living, development and wellbeing of his life and his family,opportunities, and about shortcomings which are influencing entire mechanism careermanagement.In the present research, we aim to offer a clear and pragmatic vision on the processof development and career management as a prevailing factor of modern entrepreneurship, both atindividual and social level. In the context of current reality, the career management is the mostimportant dimension of working with direct and immediate consequences in all areas of socialdevelopment