Optical And Physical Properties Of Er3+-yb3+ Co-doped Tellurite Fibers

In this work we present results of physical and optical properties of Er3+-Yb3+ co-doped tellurite glasses and fibers. The Double Clad Tellurite Fibers (DCTFs) are based on glasses with the composition: TeO2-WO3-Nb2O5-Na 2O-Al2O3-Er2O3-Yb 2O3. The DCTFs were fabricated by using the rod-in-tube technique and a Heathway drawing tower. The optical absorption spectra (ranging from 350 to 1750 nm) of these fibers were measured using an Optical Spectrum Analyzer (OSA). The emission spectra, around 1550 nm band, of these fibers (lengths varying from 1 to 60 cm) were obtained by using a 980nm diode laser pump. The optimal Amplified Spontaneous Emission (ASE) spectra were observed for fiber lengths ranging from 2 to 6 cm. The Er 3+/Yb3+ co-doped DCTFs show an efficient up-conversion process in comparison with the Er3+-doped DCTF. © 2011 Copyright Society of Photo-Optical Instrumentation Engineers (SPIE).8120The Society of Photo-Optical Instrumentation Engineers (SPIE)Murugan, G.S., Suzuki, T., Ohishi, Y., Raman characteristics and nonlinear optical properties of tellurite and phosphotellurite glasses containing heavy metal oxides with ultrabroad Raman bands (2006) J. of Appl. Phys., 100, p. 023107Nandi, P., Jose, G., Ytterbium-doped P2O5-TeO2 glass for laser applications (2006) IEEE J. of Quat. Electron., 42, pp. 1115-1121Man, S.Q., Pun, E.Y.B., Chung, P.S., Tellurite glasses for 1.3 mm optical amplifiers" (1999) Opt. Comm., 168, pp. 369-373Wang, J.S., Vogel, E.M., Snitzer, E., Tellurite Glass: A New Candidate for Fiber Devices" (1994) Opt. Mat., 3, pp. 187-203Xu, S., Sun, H., Dai, S., Zhang, J., Jiang, Z., Upconversion luminescence of Tm3+/Yb3+-codoped oxyhalide tellurite glasses" (2005) Sol. St. Comm., 133, pp. 89-92Bookey, H.T., Lousteau, J., Jha, A., Gayraud, N., Thomson, R.R., Psaila, N.D., Li, H., Kar, A.K., Multiple rare earth emissions in a multicore tellurite fiber with a single pump wavelength" (2007) Opt. Express, 15, pp. 17554-17561Qin, G., Mori, A., Ohishi, Y., Brillouin lasing in a single-mode tellurite fiber" (2007) Opt. Lett., 32, pp. 2179-2181Zweig, A.D., Frenz, M., Romano, V., Weber, H.P., A comparative study of laser tissue interaction at 2.94 μm and 10.6 μm" (1988) Appl. Phys. B, 47, pp. 259-265Zhang, J., Dai, S., Wang, G., Sun, H., Zhang, L., Hu, L., Fabrication and emission properties of Er3+/Yb3+ codoped tellurite glass fiber for broadband optical amplification (2005) J. of Lum., 115, pp. 45-52Shixun, D., Tiefeng, X., Qiuhua, N., Xiang, S., Xunsi, W., Fabrication and gain performance of Er3+/Yb3+-codoped tellurite glass fiber (2008) J. of Rare Earths, 26, pp. 915-918Jakutis, J., Gomes, L., Amancio, C.T., Kassab, L.R.P., Martinelli, J.R., Wetter, N.U., Increased Er3+ upconversion in tellurite fibers and glasses by co-doping with Yb3+ (2010) Opt. Mat., 33, pp. 107-111Hruby, A., Evaluation of glass-forming tendency by means of DTA (1972) Czech J. Phys B, 22, pp. 1187-119

Wnt target genes identified by DNA microarrays in immature CD34+ thymocytes regulate proliferation and cell adhesion

The thymus is seeded by very small numbers of progenitor cells that undergo massive proliferation before differentiation and rearrangement of TCR genes occurs. Various signals mediate proliferation and differentiation of these cells, including Wnt signals. Wnt signals induce the interaction of the cytoplasmic cofactor beta-catenin with nuclear T cell factor (TCF) transcription factors. We identified target genes of the Wnt/beta-catenin/TCF pathway in the most immature (CD4-CD8-CD34+) thymocytes using Affymetrix DNA microarrays in combination with three different functional assays for in vitro induction of Wnt signaling. A relatively small number (approximately 30) of genes changed expression, including several proliferation-inducing transcription factors such as c-fos and c-jun, protein phosphatases, and adhesion molecules, but no genes involved in differentiation to mature T cell stages. The adhesion molecules likely confine the proliferating immature thymocytes to the appropriate anatomical sites in the thymus. For several of these target genes, we validated that they are true Wnt/beta-catenin/TCF target genes using real-time quantitative PCR and reporter gene assays. The same core set of genes was repressed in Tcf-1-null mice, explaining the block in early thymocyte development in these mice. In conclusion, Wnt signals mediate proliferation and cell adhesion, but not differentiation of the immature thymic progenitor pool