2,887 research outputs found
Beyond the pale?: the implications of the RSLG Report for non-CURL modern university libraries: Perspectives on the support libraries group: Final report
We have shown that the cluster-mass reconstruction method
which combines strong and weak gravitational lensing data, developed
in the first paper in the series, successfully reconstructs the
mass distribution of a simulated cluster. In this paper we apply the method to the
ground-based high-quality multi-colour data of RX J1347.5-114
GaBoDS: The Garching-Bonn Deep Survey -- II. Confirmation of EIS cluster candidates by weak gravitational lensing
We report the first confirmation of colour-selected galaxy cluster candidates
by means of weak gravitational lensing. Significant lensing signals were
identified in the course of the shear-selection programme of dark matter haloes
in the Garching-Bonn Deep Survey, which currently covers 20 square degrees of
deep, high-quality imaging data on the southern sky. The detection was made in
a field that was previously covered by the ESO Imaging Survey (EIS) in 1997. A
highly significant shear-selected mass-concentration perfectly coincides with
the richest EIS cluster candidate at z~0.2, thus confirming its cluster nature.
Several other shear patterns in the field can also be identified with cluster
candidates, one of which could possibly be part of a filament at z~0.45.Comment: 4 pages, 4 figures, submitted to A&A Letter
Inhibiting CDK4/6 in pancreatic ductal adenocarcinoma via microRNA-21
Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive malignancies, with a 5-year survival rate of 5â10 %. The high mortality rate is due to the asymptomatic progression of clinical features in metastatic stages of the disease, which renders standard therapeutic options futile. PDAC is characterised by alterations in several genes that drive carcinogenesis and limit therapeutic response. The two most common genetic aberrations in PDAC are the mutational activation of KRAS and loss of the tumour suppressor CDK inhibitor 2A (CDKN2A), which culminate the activation of the cyclin-dependent kinase 4 and 6 (CDK4/6), that promote G1 cell cycle progression. Therapeutic strategies focusing on the CDK4/6 inhibitors such as palbociclib (PD-0332991) may potentially improve outcomes in this malignancy. MicroRNAs (miRs/miRNAs) are small endogenous non-coding RNA molecules associated with cellular proliferation, invasion, apoptosis, and cell cycle. Primarily, miR-21 promotes cell proliferation and a higher proportion of PDAC cells in the S phase, while knockdown of miR-21 has been linked to cell cycle arrest at the G2/M phase and inhibition of cell proliferation. In this study, using a CRISPR/Cas9 loss-of-function screen, we individually silenced the expression of miR-21 in two PDAC cell lines and in combination with PD-0332991 treatment, we examined the synergetic mechanisms of CDK4/6 inhibitors and miR-21 knockouts (KOs) on cell survival and death. This combination reduced cell proliferation, cell viability, increased apoptosis and G1 arrest in vitro. We further analysed the mitochondrial respiration and glycolysis of PDAC cells; then assessed the protein content of these cells and revealed numerous Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways associated with PD-0332991 treatment and miR-21 knocking out. Our results demonstrate that combined targeting of CDK4/6 and silencing of miR-21 represents a novel therapeutic strategy in PDAC
Cosmic shear analysis of archival HST/ACS data: I. Comparison of early ACS pure parallel data to the HST/GEMS Survey
This is the first paper of a series describing our measurement of weak
lensing by large-scale structure using archival observations from the Advanced
Camera for Surveys (ACS) on board the Hubble Space Telescope (HST).
In this work we present results from a pilot study testing the capabilities
of the ACS for cosmic shear measurements with early parallel observations and
presenting a re-analysis of HST/ACS data from the GEMS survey and the GOODS
observations of the Chandra Deep Field South (CDFS). We describe our new
correction scheme for the time-dependent ACS PSF based on observations of
stellar fields. This is currently the only technique which takes the full time
variation of the PSF between individual ACS exposures into account. We estimate
that our PSF correction scheme reduces the systematic contribution to the shear
correlation functions due to PSF distortions to < 2*10^{-6} for galaxy fields
containing at least 10 stars. We perform a number of diagnostic tests
indicating that the remaining level of systematics is consistent with zero for
the GEMS and GOODS data confirming the success of our PSF correction scheme.
For the parallel data we detect a low level of remaining systematics which we
interpret to be caused by a lack of sufficient dithering of the data.
Combining the shear estimate of the GEMS and GOODS observations using 96
galaxies arcmin^{-2} with the photometric redshift catalogue of the GOODS-MUSIC
sample, we determine a local single field estimate for the mass power spectrum
normalisation sigma_{8,CDFS}=0.52^{+0.11}_{-0.15} (stat) +/- 0.07 (sys) (68%
confidence assuming Gaussian cosmic variance) at fixed Omega_m=0.3 for a
LambdaCDM cosmology. We interpret this exceptionally low estimate to be due to
a local under-density of the foreground structures in the CDFS.Comment: Version accepted for publication in Astronomy & Astrophysics with 28
pages, 25 figures. A version with full resolution figures can be downloaded
from http://www.astro.uni-bonn.de/~schrabba/papers/cosmic_shear_acs1_v2.pd
Properties of a Polar Coronal Hole During the Solar Minimum in 2007
We report measurements of a polar coronal hole during the recent solar minimum using the Extreme Ultraviolet Imaging Spectrometer on Hinode. Five observations are analyzed that span the polar coronal hole from the central meridian to the boundary with the quiet-Sun corona. We study the observations above the solar limb in the height range of 1.03-1.20 R â. The electron temperature T e and emission measure (EM) are found using a geometric mean emission measure method. The EM derived from the elements Fe, Si, S, and Al are compared in order to measure relative coronal-to-photospheric abundance enhancement factors. We also studied the ion temperature T i and the non-thermal velocity v nt using the line profiles. All these measurements are compared to polar coronal hole observations from the previous (1996-1997) solar minimum and to model predictions for relative abundances. There are many similarities in the physical properties of the polar coronal holes between the two minima at these low heights. We find that the electron density, T e, and T i are comparable in both minima. T e shows a comparable gradient with height. Both minima show a decreasing T i with increasing charge-to-mass ratio q/M. A previously observed upturn of T i for ions above q/M>0.25 was not found here. We also compared relative coronal-to-photospheric elemental abundance enhancement factors for a number of elements. These ratios were ~1 for both the low first ionization potential (FIP) elements Si and Al and the marginally high FIP element S relative to the low FIP element Fe, as is expected based on earlier observations and models for a polar coronal hole. These results are consistent with no FIP effect in a polar coronal hole
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