OR to predict infections associated with nearest predictor measurements adjusted for age, NIHSS and CI as well as supra- or infratentorial infarct localization.

<p>PCT: procalcitonin; CRP: C-reactive protein; WBC: white blood cells; Mcyt: monocytes.</p

Baseline Data.

<p>UTI: urinary tract infection; CRP: C-reactive protein; WBC: white blood cells; NIHSS: National Institutes of Health Stroke Scale; BP: blood pressure; IQR: interquartile range (log transformed), AH: arterial hypertension; PAD: peripheral artery disease; CHD: coronary heart disease; Hyperchol: Hypercholestrolemia.</p

Comparison of AUCs for developing infection between the predictors WBC, Mcyt, CRP and Copeptin.

<p>PCT: procalcitonin; CRP: C-reactive protein; WBC: white blood cells; Mcyt: monocytes.</p

OR/AUC to predict infections (measurements on admission (day 0)).

<p>OR referred to an increment to predict values from the 1^st to the 3^th interquartile range (IQR). IQRs for the parameters are given in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0048309#pone-0048309-t001" target="_blank">Table 1</a>.</p><p>PCT: procalcitonin; CRP: C-reactive protein; WBC: white blood cells; Mcyt: monocytes.</p

Comparison of batches with best predictors of specific type of infection alone.

<p>WBC: white blood cells; CRP: C-reactive protein; PCT: procalcitonin. AUC: Area under the curve to predict infection using the combined model of all predictors.g.</p>*<p>adjusted for all predictors in the respective model.</p>**<p>Wald-p: refers to the comparison of the combined model with the model of the strongest predictor, alone which always was WBC.</p

Odds ratios/AUC to predict infections associated with nearest predictor measurements*.

<p>OR referred to an increment to predict values from the 1^st to the 3^th interquartile range (IQR). IQRs for the parameters are given in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0048309#pone-0048309-t001" target="_blank">Table 1</a>.</p><p>PCT: procalcitonin; CRP: C-reactive protein; WBC: white blood cells; Mcyt: monocytes performed 1 or 2 days prior to the onset of infection.</p

Additional file 1: of Selection bias in clinical stroke trials depending on ability to consent

Full dataset supporting the manuscript. (CSV 60 kb

Timecourse of plasma MR-proANP levels.

<p>Plasma lnMR-proANP levels are plotted on the ordinate, lnMR-proANP levels were significantly different between patient groups throughout the monitored period (day 0 denotes the day of admission; ** p<0.01, *** p<0.001, one-way ANOVA with Bonferroni’s multiple comparisons post-hoc test). The abscissa denotes the time points of plasma MR-proANP levels during the hospitalization period in patients with no newly-diagnosed atrial fibrillation (no NDAF, blue boxes) and those with newly-diagnosed atrial fibrillation (NDAF, red boxes). Horizontal bars indicate group means with error bars denoting 95% CI.</p

Comparison of the area under the receiver operating characteristic curve of each model in cohort A.

<p>*p<0.05<b>.</b></p

Baseline characteristics of patient cohorts as described in figure 1.

<p>(INS  =  insular stroke, NDAF  =  newly diagnosed atrial fibrillation, NIHSS  =  National Institute of Health Stroke Scale, IQR  =  Interquartile Range, CAD  =  coronary artery disease).*p<0.05.</p