Alcohol Use and Trauma Exposure Among Male and Female Veterans Before, During, and After Military Service

Background: The present study examined lifespan and combat-related trauma exposure as predictors of alcohol use among male and female veterans. Posttraumatic stress and depressive symptoms were examined as mediators of the effects of trauma exposure on alcohol use. Methods: Data were examined from 1825 (1450 male, 375 female) veterans and active duty service members who took part in a multi-site research study conducted through the Department of Veterans Affairs Mid-Atlantic Mental Illness Research, Education and Clinical Center (VISN 6 MIRECC). Results: For both men and women, depressive symptoms significantly mediated the effects of non-combat trauma exposure experienced before, during and after the military, as well as combat-exposure, on alcohol use. With posttraumatic stress symptoms, the models for men and women differed. For men, the effects of non-combat trauma exposure during and after military service, and combat exposure, on alcohol use were mediated by PTSD symptoms; however, for women, PTSD symptoms did not mediate these relationships. Conclusion: Findings are discussed in the context of potential gender differences in response to trauma such as use of alcohol to cope with traumatic events

The factor structure of psychiatric comorbidity among Iraq/Afghanistan-era veterans and its relationship to violence, incarceration, suicide attempts, and suicidality

The present research examined how incarceration, suicide attempts, suicidality, and difficulty controlling violence relate to the underlying factor structure of psychiatric comorbidity among a large sample of Iraq/Afghanistan-era veterans (N = 1897). Diagnostic interviews established psychiatric diagnoses; self-report measures assessed history of incarceration, difficulty controlling violence, suicide attempts, and suicidality. A 3-factor measurement model characterized by latent factors for externalizing-substance-use disorders (SUD), distress, and fear provided excellent fit to the data. Alcohol-use disorder, drug-use disorder, and nicotine dependence were indicators on the externalizing-SUD factor. Posttraumatic stress disorder and depression were indicators on the distress factor. Panic disorder, social phobia, specific phobia, and obsessive-compulsive disorder were indicators on the fear factor. Incarceration was exclusively predicted by the externalizing-SUD factor. Difficulty controlling violence, suicidality, and suicide attempts were exclusively predicted by the distress factor. Contrary to hypotheses, the path from the externalizing/SUD factor to difficulty controlling violence was not significant. Taken together, these findings suggest that the distress factor of psychiatric comorbidity is a significant risk factor for suicidality, suicide attempts, and difficulty controlling violence and could help to explain the frequent co-occurrence of these critical outcomes among returning Iraq/Afghanistan veterans

Screening for Violence Risk in Military Veterans: Predictive Validity of a Brief Clinical Tool

Violence toward others is a serious problem among a subset of military veterans. This study reports on predictive validity of a brief screening tool for violence in veterans

Screening for Violence Risk in Military Veterans: Predictive Validity of a Brief Clinical Tool

OBJECTIVE: Violence toward others is a serious problem among a subset of military veterans. This study reports on predictive validity of a brief screening tool for violence in veterans. METHODS: Data on risk factors at an initial wave and on violent behavior at 1-year follow-up were collected in two independent sampling frames: (a) a national random sample survey of 1090 Iraq and Afghanistan veterans, and (b) in-depth assessments of 197 dyads of Iraq and Afghanistan veterans and collateral informants. RESULTS: We chose candidate risk factors—financial instability, combat experience, alcohol misuse, history of violence and arrests, and anger associated with posttraumatic stress disorder (PTSD)—based on empirical support in published research. Tools measuring these risk factors were examined, and items with the most robust statistical association to outcomes were selected. The resultant 5-item clinical tool, the Violence Screening and Assessment of Needs (VIO-SCAN), yielded area under the curve (AUC) statistics ranging from .74 – .78 for the national survey and from .74 – .80 for the in-depth assessments, depending on level of violence analyzed using multiple logistic regression. CONCLUSIONS: To our knowledge, the VIO-SCAN is the first empirically-derived assessment tool for violence developed specifically for military veteran populations. As in civilians, past violence and arrest history had a robust association with future violence in veterans. Analyses show that individual factors examined in isolation (e.g., PTSD, combat experience) do not adequately convey a veteran’s level of violence risk; rather, as shown by the VIO-SCAN, multiple risk factors need to be taken into account in tandem when assessing risk in veterans. Use of evidence-based methods for assessing and managing violence in veterans is discussed, addressing benefits and limits of integrating risk assessment tools into clinical practice

Brain Structural Covariance Network Topology in Remitted Posttraumatic Stress Disorder

Posttraumatic stress disorder (PTSD) is a prevalent, chronic disorder with high psychiatric morbidity; however, a substantial portion of affected individuals experience remission after onset. Alterations in brain network topology derived from cortical thickness correlations are associated with PTSD, but the effects of remitted symptoms on network topology remain essentially unexplored. In this cross-sectional study, US military veterans (N = 317) were partitioned into three diagnostic groups, current PTSD (CURR-PTSD, N = 101), remitted PTSD with lifetime but no current PTSD (REMIT-PTSD, N = 35), and trauma-exposed controls (CONTROL, n = 181). Cortical thickness was assessed for 148 cortical regions (nodes) and suprathreshold interregional partial correlations across subjects constituted connections (edges) in each group. Four centrality measures were compared with characterize between-group differences. The REMIT-PTSD and CONTROL groups showed greater centrality in left frontal pole than the CURR-PTSD group. The REMIT-PTSD group showed greater centrality in right subcallosal gyrus than the other two groups. Both REMIT-PTSD and CURR-PTSD groups showed greater centrality in right superior frontal sulcus than CONTROL group. The centrality in right subcallosal gyrus, left frontal pole, and right superior frontal sulcus may play a role in remission, current symptoms, and PTSD history, respectively. The network centrality changes in critical brain regions and structural networks are associated with remitted PTSD, which typically coincides with enhanced functional behaviors, better emotion regulation, and improved cognitive processing. These brain regions and associated networks may be candidates for developing novel therapies for PTSD. Longitudinal work is needed to characterize vulnerability to chronic PTSD, and resilience to unremitting PTSD